公开(公告)号：EP1401490A4

公开(公告)日：2005-09-21

申请号：EP02731876

申请日：2002-05-21

申请人： UNIV NEW YORK STATE RES FOUND ,  COHEN STANLEY N

发明人： COHEN S N ,  CARTER CAROL ,  GOFF ARTHUR ,  EHRLICH LORNA

IPC分类号： A61K38/00 ,  A61K38/17 ,  A61P31/12 ,  A61P31/18 ,  C07H21/04 ,  C07K7/06 ,  C07K7/08 ,  C07K14/16 ,  C07K14/47 ,  C12N15/09 ,  C12P21/02 ,  C12Q1/02 ,  C12Q1/68 ,  G01N33/15 ,  G01N33/50 ,  G01N33/53 ,  G01N33/569 ,  G01N33/68 ,  A61K39/21 ,  A01N43/04 ,  C12N5/00 ,  C12N15/00 ,  C12N15/63 ,  C12N15/64

CPC分类号： G01N33/502 ,  A61K38/1709 ,  C07K14/005 ,  C07K14/4702 ,  C07K2319/00 ,  C12N2740/16222 ,  G01N33/5008 ,  G01N33/56983 ,  G01N33/56988 ,  G01N33/6878 ,  G01N2333/16 ,  G01N2333/161 ,  G01N2500/02 ,  G01N2500/10 ,  G01N2500/20

摘要： The present invention provides methods for identifying peptides in a mammalian Tsg101 protein that binds to the PTAPP motif or L domain of human immunodeficiency virus type I (HIV-1). Such peptides can be used to inhibit Tsg101-HIV Gag binding, and is therefore effective in reducing HIV particle production. The invention also provides the peptides identified by the method of the invention and to method of using such peptides for treating HIV infection.