公开(公告)号：EP3033108A4

公开(公告)日：2017-07-05

申请号：EP14836047

申请日：2014-08-18

申请人： UNIV ROCHESTER

发明人： MILLER BENJAMIN L ,  DE BENEDETTO ANNA ,  BECK LISA A ,  ANDERSON ELIZABETH A

IPC分类号： A61K39/395 ,  A61K31/7088 ,  A61K38/10

CPC分类号： A61K38/17 ,  A61K9/0014 ,  A61K9/0043 ,  A61K38/00 ,  A61K38/44 ,  A61K39/12 ,  A61K39/145 ,  A61K39/39 ,  A61K2039/54 ,  A61K2039/543 ,  A61K2039/55516 ,  C12N7/00 ,  C12N2760/16034 ,  C12N2760/16071 ,  C12N2760/16134 ,  C12Y113/12007

摘要： According to aspects illustrated herein, there is provided an agent that transiently disrupts claudin-1 within tight junctions. The agent includes a peptide having at least 40% polar, uncharged amino acid residues and a self-assembled β-sheet secondary structure. According to aspects illustrated herein, there is also provided a transepithelial drug and vaccine formulations, as well as isolated peptides, pharmaceutical compositions, and transdermal delivery devices. Also described herein are methods of disrupting epithelial barrier and methods of administering the transepithelial formulations described herein.

摘要翻译： 根据本文所述的方面，提供了在紧密连接内瞬时破坏密蛋白-1的试剂。 该药剂包括具有至少40％极性，不带电荷的氨基酸残基和自组装β-折叠二级结构的肽。 根据本文所述的方面，还提供了跨上皮药物和疫苗制剂，以及分离的肽，药物组合物和透皮递送装置。 本文还描述了破坏上皮屏障的方法和施用本文所述的跨上皮制剂的方法。