公开(公告)号：EP0808369A1

公开(公告)日：1997-11-26

申请号：EP96900796

申请日：1996-01-24

申请人： UNIV SASKATCHEWAN

发明人： POTTER ANDREW A ,  MANNS JOHN G

IPC分类号： C12N15/09 ,  A61K38/00 ,  A61K39/00 ,  A61K47/48 ,  A61P43/00 ,  C07K5/103 ,  C07K5/11 ,  C07K5/113 ,  C07K5/117 ,  C07K7/23 ,  C07K14/14 ,  C07K14/285 ,  C07K14/655 ,  C07K16/26 ,  C07K19/00 ,  C12N1/21 ,  C12N15/00 ,  C12N15/31 ,  C12P21/02 ,  C12R1/19 ,  C12R1/91 ,  C12N15/62 ,  A61K38/09 ,  A61K39/385

CPC分类号： C07K5/1024 ,  A61K39/00 ,  A61K39/0006 ,  A61K47/62 ,  A61K47/646 ,  A61K47/6829 ,  A61K47/6833 ,  A61K2039/6037 ,  C07K5/1008 ,  C07K5/1019 ,  C07K5/1021 ,  C07K7/23 ,  C07K14/005 ,  C07K14/285 ,  C07K14/655 ,  C07K16/26 ,  C07K2319/00 ,  C12N2720/12322

摘要： New immunological carrier systems, DNA encoding the same, and the use of these systems, are disclosed. The carrier systems include chimeric proteins which comprise a leukotoxin polypeptide fused to a selected GnRH multimer which consists essentially of at least one repeating GnRH decapepetide sequence, or at least one repeating unit of a sequence corresponding to at least one epitope of a selected GnRH molecule. Under the invention, the selected GnRH sequences may all be the same, or may correspond to different derivatives, analogues, variants or epitopes of GnRH so long as the GnRH sequences are capable of eliciting an immune response. The leukotoxin functions to increase the immunogenicity of the GnRH multimer fused thereto.