公开(公告)号：EP1421055A4

公开(公告)日：2005-01-19

申请号：EP02764370

申请日：2002-08-26

申请人： POLYCHIP PHARMACEUTICALS PTY ,  UNIV VICTORIA

发明人： SMALLRIDGE ANDREW JOHN ,  TREWHELLA MAURICE ARTHUR ,  WILKINSON KYLIE ANNE

IPC分类号： C12P13/02 ,  C07B61/00 ,  C07C209/24 ,  C07C209/26 ,  C07C211/17 ,  C07C211/27 ,  C07C211/29 ,  C07C213/02 ,  C07C215/30 ,  C07C215/34 ,  C07C215/60 ,  C07C249/02 ,  C12R1/865

CPC分类号： C07C213/02 ,  C07C209/26 ,  C07C249/02 ,  C07C2601/14 ,  Y02P20/544 ,  C07C211/17 ,  C07C211/27 ,  C07C211/29 ,  C07C215/30 ,  C07C215/60

公开(公告)号：EP1240347A4

公开(公告)日：2003-04-16

申请号：EP00984642

申请日：2000-12-13

申请人： UNIV VICTORIA ,  POLYCHIP PHARMACEUTICALS PTY

发明人： SMALLRIDGE ANDREW JOHN ,  TREWHELLA MAURICE ARTHUR ,  WILKINSON KYLIE ANNE

IPC分类号： C12P7/26 ,  C07C45/45 ,  C07C49/245 ,  C12P7/28

CPC分类号： C12P7/26 ,  Y02P20/544

摘要： The invention provides a method of synthesis of a substituted or unsubstituted carbinol compound, comprising the steps of subjecting the corresponding substituted or unsubstituted aromatic aldehyde to acyloin condensation mediated by yeast in the presence of either (a) a supercritical fluid or (b) a liquefied gas, and recovering the carbinol compound. Preferably the yeast is Saccharomyces cerevisiae . In a particularly preferred embodiment the aromatic aldehyde is benzaldehyde and the carbinol is phenylacetylcarbinol, according to the reaction (I): in which the benzaldehyde, the pyruvic acid, or both may optionally be substituted.