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1.发明公开COMPOSITE PREPARATION PROCESS ON A BASIS OF BIOCERAMICS AND BIODEGRADABLE OR NON BIODEGRADABLE POLYMERS, CEMENTING AND/OR CARRIER SUBSTANCES CONTAINING ENCAPSULATED OR NON-ENCAPSULATED MICRO OR NANOPARTICULATED ANTIBIOTICS AND ANGIOSTENSIN (1-7) FOR TISSUE RESTITUTION AND PRODUCTS THEREFROM 审中-公开复合材料的方法基于对组织归还及其产品生物陶瓷和生物可降解或不可生物降解聚合物，水泥和/或载体物质或包封的未包封的微粒或纳米微粒的抗生素和血管紧张素（1-7）
公开(公告)号：EP2035051A1
公开(公告)日：2009-03-18
申请号：EP07719328.2
申请日：2007-05-18
CPC分类号： A61L31/16 , A61K38/085 , A61L27/46 , A61L27/54 , A61L27/58 , A61L31/127 , A61L31/148 , A61L2300/406 , A61L2300/622 , A61L2300/624 , A61K2300/00 , C08L67/04
摘要： This invention is characterized by the preparation of composites made from bioceramics containing calcium salts like Ca5(PO4)3OH, CaCO3, CaSO4, Ca3(PO4), CaOSiO2(NO3)2, Ca10(PO4)6(OH)2, according to patent BR 10 PI9104220-8, (2000), natural and/or synthetic biodegradable or non biodegradable polymers, calcium phosphate cements, either natural or synthetic containing encapsulated or non- encapsulated micro or nanoparticulated antibiotics and angiotensin (1-7) in the form of suspensions, cosmetics, grafts and uses of such compositions in the process of tissue restitution. The composites containing antibiotics and angiotensin (1-7) can be used as grafts in humans and as veterinary medicinal products effective both as antibiotic and osteoconductor. Another feature of this invention is the use of tetracyclines in the composites, in concentrations that may vary from 0,001 % to 5%, effective as anti-inflammatory. The bioceramics/polymer composites claimed in this document display the induction properties of the repairing dentine, formation of compact dentine bridge.
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