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1.发明授权NOVEL ADENYL DINUCLEOTIDES WITH ANTITUMOUR ACTIVITY AND A METHOD FOR PREPARING THEREOF 有权新ADENYLDINUKLEOTIDE具有抗肿瘤作用及其制造方法
公开(公告)号：EP1879907B1
公开(公告)日：2009-05-20
申请号：EP06728073.5
申请日：2006-04-28
发明人： BASILE, Giovanna , BENATTI, Umberto , BRUZZONE, Santina , DAMONTE, Gianluca , DE FLORA, Antonio , FATTORUSSO, Ernesto , FRANCO, Luisa , GUIDA, Lucrezia , TAGLIALATELA-SCAFATI, Orazio , ZOCCHI, Elena
IPC分类号： C07H21/04
CPC分类号： C07H21/04
摘要： The invention relates to novel adenyl dinucleotides which are isomers of the dinucleotide Ap2A, having formulae (I) and (II) . The dinucleotides of the invention have antitumour activity, particularly against tumours of haematological origin, such as for example leukaemias and lymphomas. The invention further relates to the use of such dinucleotides as antitumour medicaments. Finally, the invention relates to an enzymatic method for preparing the dinucleotides of formulae (I) and (II) and to an enzymatic assay method for the dinucleotide of formula (I) which is based on its complete conversion to NAD + .
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2.发明公开NOVEL ADENYL DINUCLEOTIDES WITH ANTITUMOUR ACTIVITY AND A METHOD FOR PREPARING THEREOF 有权新ADENYLDINUKLEOTIDE具有抗肿瘤作用及其制造方法
公开(公告)号：EP1879907A1
公开(公告)日：2008-01-23
申请号：EP06728073.5
申请日：2006-04-28
发明人： BASILE, Giovanna , BENATTI, Umberto , BRUZZONE, Santina , DAMONTE, Gianluca , DE FLORA, Antonio , FATTORUSSO, Ernesto , FRANCO, Luisa , GUIDA, Lucrezia , TAGLIALATELA-SCAFATI, Orazio , ZOCCHI, Elena
IPC分类号： C07H21/04
CPC分类号： C07H21/04
摘要： The invention relates to novel adenyl dinucleotides which are isomers of the dinucleotide Ap2A, having formulae (I) and (II) . The dinucleotides of the invention have antitumour activity, particularly against tumours of haematological origin, such as for example leukaemias and lymphomas. The invention further relates to the use of such dinucleotides as antitumour medicaments. Finally, the invention relates to an enzymatic method for preparing the dinucleotides of formulae (I) and (II) and to an enzymatic assay method for the dinucleotide of formula (I) which is based on its complete conversion to NAD+ .
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公开(公告)号：EP1948174B1
公开(公告)日：2012-08-01
申请号：EP06821174.7
申请日：2006-10-06
发明人： ZOCCHI, Elena , GUIDA, Lucrezia , BRUZZONE, Santina , SCARFI', Sonia , MAGNONE, Mirko , BASILE, Giovanna , BENATTI, Umberto , DE FLORA, Antonio , MORESCHI, Iliana , FRANCO, Luisa , SALIS, Annalisa
IPC分类号： A61K31/4412 , A61P29/00 , A61K31/19
CPC分类号： A61K31/19 , A61K31/4412 , C07D213/68 , Y10S514/886
摘要： The invention relates to a novel use of fluridone - compound known per se and used as an aquatic erbicide - in the medical field, in particular as an active compound for preparing a medicament having anti-inflammatory activity. Pharmaceutical compositions comprising fluridone as an active compound and pharmaceutically acceptable carriers and/or diluents are also disclosed. Finally, there is disclosed the pro-inflammatory activity of abscisic acid (ABA), a plant hormone which is also found in mammal serum and against which fluridone acts an an inhibitor.
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公开(公告)号：EP1948174A2
公开(公告)日：2008-07-30
申请号：EP06821174.7
申请日：2006-10-06
发明人： ZOCCHI, Elena , GUIDA, Lucrezia , BRUZZONE, Santina , SCARFI', Sonia , MAGNONE, Mirko , BASILE, Giovanna , BENATTI, Umberto , DE FLORA, Antonio , MORESCHI, Iliana , FRANCO, Luisa , SALIS, Annalisa
IPC分类号： A61K31/4412 , A61P29/00 , A61K31/19
CPC分类号： A61K31/19 , A61K31/4412 , C07D213/68 , Y10S514/886
摘要： The invention relates to a novel use of fluridone - compound known per se and used as an aquatic erbicide - in the medical field, in particular as an active compound for preparing a medicament having anti-inflammatory activity. Pharmaceutical compositions comprising fluridone as an active compound and pharmaceutically acceptable carriers and/or diluents are also disclosed. Finally, there is disclosed the pro-inflammatory activity of abscisic acid (ABA), a plant hormone which is also found in mammal serum and against which fluridone acts an an inhibitor.
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