公开(公告)号：EP1383520B1

公开(公告)日：2013-09-18

申请号：EP02721902.1

申请日：2002-04-23

Applicant: Smith & Nephew (Overseas) Limited

Inventor： BURRELL, Robert, Edward ,  NAYLOR, Antony, George ,  MOXHAM, Peter, Howard

IPC: A61K33/00 ,  A61K33/24 ,  A61K33/38 ,  A61K33/40 ,  A61K9/00 ,  A61K9/08 ,  A61K9/12 ,  A61K9/14 ,  A61K9/70 ,  A61P1/02 ,  A61P11/02 ,  A61P11/04 ,  A61P43/00 ,  A61P29/00

CPC classification number: A61K9/0024 ,  A01N59/16 ,  A61K9/0019 ,  A61K9/0075 ,  A61K9/0078 ,  A61K9/14 ,  A61K9/7007 ,  A61K33/24 ,  A61K33/38 ,  A61K33/40 ,  A61K47/34 ,  A61K47/38 ,  A61L15/46 ,  A61L17/145 ,  A61L27/30 ,  A61L29/10 ,  A61L31/082 ,  A61L2300/102 ,  A61L2300/104 ,  A61L2300/404 ,  A61L2300/452 ,  A61L2300/606 ,  A61L2300/624 ,  A61L2300/63 ,  Y10S424/15 ,  Y10S514/825 ,  Y10S514/826 ,  Y10S514/829 ,  Y10S514/83 ,  Y10S514/849 ,  Y10S514/851 ,  Y10S514/853 ,  Y10S514/861 ,  Y10S514/862 ,  Y10S514/864 ,  Y10S514/865 ,  Y10S514/88 ,  Y10S514/881 ,  Y10S514/882 ,  Y10S514/886 ,  Y10S514/887 ,  Y10S514/90 ,  Y10S514/901 ,  Y10S514/902 ,  Y10S514/912 ,  Y10S514/914 ,  Y10S514/925 ,  Y10S514/931 ,  Y10S514/932 ,  Y10S514/933 ,  Y10S514/934 ,  Y10S514/944 ,  Y10S514/951 ,  Y10S514/953 ,  Y10S514/954 ,  Y10S514/956 ,  Y10S514/958 ,  Y10S514/964 ,  Y10S514/965 ,  Y10S514/966 ,  Y10S514/967 ,  Y10S514/968 ,  Y10S514/969 ,  Y10T428/31855 ,  A61K2300/00 ,  A01N25/04 ,  A01N25/10 ,  A01N25/12

公开(公告)号：EP1060739B1

公开(公告)日：2013-04-03

申请号：EP00480049.6

申请日：2000-06-06

Applicant: EXSYMOL S.A.M.

Inventor： Seguin, Marie-Christine

IPC: A61K8/44 ,  A61K8/64 ,  A61Q19/06

CPC classification number: A61K8/64 ,  A61K8/44 ,  A61Q19/06 ,  Y10S514/886 ,  Y10S514/909 ,  Y10S514/912 ,  Y10S514/914 ,  Y10S514/937 ,  Y10S514/944 ,  Y10S514/945

公开(公告)号：EP1948174B1

公开(公告)日：2012-08-01

申请号：EP06821174.7

申请日：2006-10-06

Applicant: UNIVERSITA DEGLI STUDI DI GENOVA

Inventor： ZOCCHI, Elena ,  GUIDA, Lucrezia ,  BRUZZONE, Santina ,  SCARFI', Sonia ,  MAGNONE, Mirko ,  BASILE, Giovanna ,  BENATTI, Umberto ,  DE FLORA, Antonio ,  MORESCHI, Iliana ,  FRANCO, Luisa ,  SALIS, Annalisa

IPC: A61K31/4412 ,  A61P29/00 ,  A61K31/19

CPC classification number: A61K31/19 ,  A61K31/4412 ,  C07D213/68 ,  Y10S514/886

Abstract: The invention relates to a novel use of fluridone - compound known per se and used as an aquatic erbicide - in the medical field, in particular as an active compound for preparing a medicament having anti-inflammatory activity. Pharmaceutical compositions comprising fluridone as an active compound and pharmaceutically acceptable carriers and/or diluents are also disclosed. Finally, there is disclosed the pro-inflammatory activity of abscisic acid (ABA), a plant hormone which is also found in mammal serum and against which fluridone acts an an inhibitor.

公开(公告)号：EP2465522A1

公开(公告)日：2012-06-20

申请号：EP12152769.1

申请日：2008-03-25

Applicant: Isis Innovation Limited

Inventor： Greaves, David, R ,  Russ, Andreas ,  Cash, Jenna, L.

IPC: A61K38/10 ,  A61P29/00 ,  A61P31/00 ,  C07K7/08 ,  C07K14/47

CPC classification number: A61K38/10 ,  A61K38/00 ,  A61K38/08 ,  C07K7/06 ,  C07K7/08 ,  C07K14/47 ,  Y10S514/886

Abstract: This invention provides the use of one or more peptides derived from the C-terminal end of a Chemerin protein, or analogs or derivatives thereof for treatment of inflammation and/or endotoxic shock and/or treatment of wounds and/or reduction of levels of inflammatory chemokines in a subject, and one or more peptides derived from the C-terminal end of a Chemerin protein, or analogs or derivatives thereof for use in the treatment of inflammation and/or endotoxic shock, and/or wounds, or for the reduction of levels of inflammatory mediators.

Abstract translation: 本发明提供了一种或多种衍生自Chemerin蛋白C末端的肽或其类似物或衍生物用于治疗炎症和/或内毒素休克和/或治疗伤口和/或降低炎症水平的用途 受试者中的趋化因子和衍生自切尔曼蛋白C末端的一种或多种肽，或其类似物或衍生物，用于治疗炎症和/或内毒素性休克，和/或伤口，或用于减少 炎症介质水平。

公开(公告)号：EP2274333A4

公开(公告)日：2011-06-15

申请号：EP09723430

申请日：2009-03-11

Applicant: ABBOTT LAB

Inventor： VALDES JOAQUIN MARIO ,  PAULSON SUSAN K

IPC: C07K16/00 ,  A61K39/00

CPC classification number: C07K16/244 ,  A61K2039/505 ,  C07K2317/21 ,  Y10S514/885 ,  Y10S514/886

公开(公告)号：EP2319518A1

公开(公告)日：2011-05-11

申请号：EP10013181.2

申请日：2003-02-03

Applicant: ALFAMA-Investigacao e Desenvolvimento de Produtos Farmaceuticos Lda.

Inventor： Haas, Werner ,  Romao, Carlos R. ,  Royo, Beatriz R. ,  Fernandes, Ana Cristina R. ,  Concalves, Isabel

IPC: A61K31/7048 ,  A61K31/695 ,  A61K31/7135 ,  A61K31/603 ,  A61K31/28 ,  A61K31/60 ,  A61K33/32 ,  A61K33/14 ,  A61P29/00 ,  A61K47/48

CPC classification number: C07F17/00 ,  A61K31/00 ,  A61K31/28 ,  A61K31/555 ,  A61K31/60 ,  A61K31/603 ,  A61K31/616 ,  A61K31/695 ,  A61K31/7048 ,  A61K31/7135 ,  A61K33/00 ,  A61K33/14 ,  A61K33/32 ,  A61K45/06 ,  A61K47/52 ,  C07F11/005 ,  C07F13/005 ,  C07F15/02 ,  Y10S514/824 ,  Y10S514/825 ,  Y10S514/826 ,  Y10S514/879 ,  Y10S514/886 ,  Y10S514/887 ,  Y10S514/894 ,  Y10S514/903 ,  Y10S514/921 ,  Y10S514/929 ,  Y10S514/95 ,  Y10S514/958 ,  Y10S514/959 ,  Y10S514/964 ,  A61K2300/00

Abstract: Several classes of in vivo carbon monoxide-releasing compounds are useful for the treatment and/or prevention of diseases, such as chronic inflammatory, e.g. rheumatoid arthritis, and of diseases with a strong inflammatory component, such as atherosclerosis, stroke, coronary disease, and Alzheimers disease. The in vivo carbon monoxide-releasing compounds can be attached to known drug vectors and/or known anti-inflammatory drugs, such as aspirin.

Abstract translation: 一些类型的体内释放一氧化碳的化合物可用于治疗和/或预防疾病，例如慢性炎症，例如慢性炎症。 类风湿性关节炎和具有强烈炎症成分的疾病，例如动脉粥样硬化，中风，冠状动脉疾病和阿尔茨海默病。 体内释放一氧化碳的化合物可以连接到已知的药物载体和/或已知的抗炎药物，例如阿司匹林。

公开(公告)号：EP1162968B1

公开(公告)日：2009-10-21

申请号：EP01900994.3

申请日：2001-01-11

Applicant: Color Access, Inc.

Inventor： ANDERSON, Jon ,  MATSUI, Mary, Steidl

IPC: A61K31/353 ,  A61K45/06 ,  A61K45/08 ,  A61P35/00 ,  A61P43/00

CPC classification number: A61K31/353 ,  A61K8/498 ,  A61K8/97 ,  A61Q19/00 ,  A61Q19/005 ,  A61Q19/02 ,  Y10S514/863 ,  Y10S514/886 ,  Y10S514/887

Abstract: The present invention relates to a method of inhibiting angiogenesis in mammalian tissue which comprises supplying to the tissue a composition comprising an effective amount of epigallocatechin-gallate, epicatechin gallate or a combination thereof. The method is particularly useful in the treatment of angiogenesis-related skin conditions in which the catechin is applied topically, such as the treatment of various skin cancers, psoriasis, spider veins or undereye circles.

公开(公告)号：EP2042181A1

公开(公告)日：2009-04-01

申请号：EP08166507.7

申请日：2003-02-03

Applicant: ALFAMA-Investigacao e Desenvolvimento de Produtos Farmaceuticos Lda.

Inventor： Haas, Werner ,  Romao, Carlos ,  Royo, Beatriz ,  Fernandes, Ana, Cristina ,  Goncalves, Isabel

IPC: A61K31/7048 ,  A61K31/695 ,  A61K31/7135 ,  A61K31/603 ,  A61K31/28 ,  A61K31/60 ,  A61K33/32 ,  A61K33/14 ,  A61P29/00 ,  A61K47/48

CPC classification number: C07F17/00 ,  A61K31/00 ,  A61K31/28 ,  A61K31/555 ,  A61K31/60 ,  A61K31/603 ,  A61K31/616 ,  A61K31/695 ,  A61K31/7048 ,  A61K31/7135 ,  A61K33/00 ,  A61K33/14 ,  A61K33/32 ,  A61K45/06 ,  A61K47/52 ,  C07F11/005 ,  C07F13/005 ,  C07F15/02 ,  Y10S514/824 ,  Y10S514/825 ,  Y10S514/826 ,  Y10S514/879 ,  Y10S514/886 ,  Y10S514/887 ,  Y10S514/894 ,  Y10S514/903 ,  Y10S514/921 ,  Y10S514/929 ,  Y10S514/95 ,  Y10S514/958 ,  Y10S514/959 ,  Y10S514/964 ,  A61K2300/00

Abstract: Several classes of in vivo carbon monoxide-releasing compounds are useful for the treatment and/or prevention of diseases, such as chronic inflammatory, e.g. rheumatoid arthritis, and of diseases with a strong inflammatory component, such as atherosclerosis, stroke, coronary disease, and Alzheimers disease. The in vivo carbon monoxide-releasing compounds can be attached to known drug vectors and/or known anti-inflammatory drugs, such as aspirin.

Abstract translation: 体内一氧化碳释放几类化合物是用于治疗和/或预防疾病的炎症有用，慢性：诸如，例如 类风湿性关节炎和疾病具有较强的炎性成分，颜色：例如动脉粥样硬化，中风，冠状动脉疾病，和阿尔茨海默氏病。 体内一氧化碳释放化合物可以连接到已知的药物载体和/或已知的消炎药，：如阿司匹林。

公开(公告)号：EP1282429B1

公开(公告)日：2008-08-20

申请号：EP01914829.5

申请日：2001-03-26

Applicant: Chiltern Pharmaceuticals Pty Ltd.

Inventor： SMITH, Robert, Alan

IPC: A61K33/06 ,  A61K33/08 ,  A61K33/10 ,  A61P1/00 ,  A61P17/00

CPC classification number: A61K33/06 ,  A61K33/14 ,  Y10S424/13 ,  Y10S514/829 ,  Y10S514/831 ,  Y10S514/886 ,  Y10S514/887 ,  Y10S514/925 ,  Y10S514/928 ,  Y10S514/944 ,  Y10S514/966 ,  A61K31/715 ,  A61K31/19 ,  A61K31/047 ,  A61K31/00 ,  A61K2300/00

Abstract: The present invention relates to an improved pharmaceutical composition useful for the topical treatment of burns, cuts, wounds, abrasions and the like, and to methods of treatment of injured body surfaces such as skin.

公开(公告)号：EP1206269A4

公开(公告)日：2007-09-12

申请号：EP00946975

申请日：2000-06-30

Applicant: GIRVAN DON H

Inventor： GIRVAN DON H

IPC: A61K33/22 ,  A61K45/06 ,  A61P17/00 ,  A61P17/06 ,  A61P17/10

CPC classification number: A61K45/06 ,  A61K33/22 ,  Y10S514/825 ,  Y10S514/826 ,  Y10S514/827 ,  Y10S514/828 ,  Y10S514/846 ,  Y10S514/847 ,  Y10S514/848 ,  Y10S514/858 ,  Y10S514/859 ,  Y10S514/86 ,  Y10S514/861 ,  Y10S514/862 ,  Y10S514/863 ,  Y10S514/864 ,  Y10S514/865 ,  Y10S514/871 ,  Y10S514/886 ,  Y10S514/887 ,  Y10S514/928 ,  A61K2300/00

Abstract: The present invention is directed to methods and compositions for treating skin disorders. The present invention is easily administered and can be used for both humans and animals. The compositions of the present invention comprise borate compounds and provide relief from skin disorder symptoms and lesions. Additionally, the present invention can be used to provide long term maintenance of symptom-free skin.

Abstract translation: 本发明涉及用于治疗皮肤病症的方法和组合物。 本发明容易施用并且可以用于人和动物。 本发明的组合物包含硼酸盐化合物并缓解皮肤病症状和损害。 此外，本发明可用于提供无症状皮肤的长期维持。