公开(公告)号：EP4359025A1

公开(公告)日：2024-05-01

申请号：EP22744283.7

申请日：2022-06-24

申请人： UNIVERSITE CLAUDE BERNARD - LYON 1 ,  Centre National de la Recherche Scientifique (CNRS) ,  ECOLE CENTRALE DE NANTES ,  Ecole Sup Chimie Phys Electroniq Lyon ,  Healshape

发明人： MARQUETTE, Christophe ,  CHERBLANC, Audrey ,  DOS SANTOS, Morgan ,  VIDAL, Luciano ,  PETIOT, Emma ,  CHASTAGNIER, Laura ,  THEPOT, Amélie ,  GODET, Baptiste

IPC分类号： A61L27/52 ,  A61L27/56

CPC分类号： A61L27/26 ,  A61L27/52 ,  A61L27/56 ,  A61L2430/0420130101

公开(公告)号：EP4359022A1

公开(公告)日：2024-05-01

申请号：EP22744282.9

申请日：2022-06-24

申请人： UNIVERSITE CLAUDE BERNARD - LYON 1 ,  Centre National de la Recherche Scientifique (CNRS) ,  Ecole Sup Chimie Phys Electroniq Lyon ,  Lab Skin Creations

发明人： MARQUETTE, Christophe ,  PETIOT, Emma ,  CHASTAGNIER, Laura ,  CHERBLANC, Audrey ,  DOS SANTOS, Morgan ,  THEPOT, Amélie ,  GODET, Baptiste

IPC分类号： A61L27/20 ,  A61L27/26 ,  A61L27/38 ,  A61L27/52 ,  A61L27/58

CPC分类号： A61L27/52 ,  A61L27/58 ,  A61L27/26 ,  A61L2430/0420130101

公开(公告)号：EP4316841A1

公开(公告)日：2024-02-07

申请号：EP22306179.7

申请日：2022-08-03

申请人： SARTORIUS STEDIM FMT SAS ,  UNIVERSITE CLAUDE BERNARD - LYON 1 ,  Institut National des Sciences Appliquees de Lyon (Insa Lyon) ,  Ecole Superieure de Chimie, Physique, Electronique de Lyon ,  Centre National de la Recherche Scientifique (CNRS)

发明人： GAY, Isabelle ,  BARBAROUX, Magali ,  DUFOUR, Alexandre ,  MARQUETTE, Christophe ,  PETIOT, Emma

IPC分类号： B33Y70/00 ,  B29C64/106 ,  C12M1/00 ,  C12M3/00 ,  C12M1/26

摘要： The invention concerns a sterile enclosure (2) intended for a printing of a biological three-dimensional structure, the sterile enclosure comprising :
- a rigid top plate (4),
- a rigid base plate (6) comprising a main face (16) intended to receive a biological three-dimensional structure,
- a flexible side wall (8) fixed to the top plate and to the base plate to form an hermetically closed casing (10) delimiting an interior chamber (11),
- a puncturable membrane (22) or an needle adapter arranged on the top plate,
- a stretcher arm (36) articulated to the top plate and to the base plate, the flexible side wall and the stretcher arm being conform to allow the move of the top plate with respect to the base plate in three perpendicular directions (X,Y,Z); the at least one stretcher arm being elastic and pushing the top plate apart from the base plate.

公开(公告)号：EP4149739A1

公开(公告)日：2023-03-22

申请号：EP21724340.1

申请日：2021-05-14

申请人： Centre National de la Recherche Scientifique ,  Université Claude Bernard Lyon 1 ,  Institut National des Sciences Appliquees de Lyon (Insa Lyon) ,  Ecole Sup Chimie Phys Electroniq Lyon

发明人： COURTIAL, Edwin-Joffrey ,  MARQUETTE, Christophe ,  COLLY, Arthur ,  BARTHES, Julien

IPC分类号： B29C64/118 ,  B29C64/232 ,  B29C64/236 ,  B29C64/40 ,  B33Y10/00 ,  B33Y30/00

公开(公告)号：EP3635034A1

公开(公告)日：2020-04-15

申请号：EP18721420.0

申请日：2018-05-09

申请人： Elkem Silicones France S.A.S. ,  Université Claude Bernard Lyon 1 ,  Centre National de la Recherche Scientifique (CNRS) ,  Institut National des Sciences Appliquées de Lyon ,  Université Jean Monnet Saint Etienne

发明人： FRANCES, Jean-Marc ,  MARIOT, David ,  MARQUETTE, Christophe ,  COURTIAL, Edwin-Joffrey ,  FULCHIRON, René ,  PERRINET, Clément

IPC分类号： C08G77/12 ,  C08G77/14 ,  C08G77/20 ,  C08L83/04 ,  B33Y70/00 ,  B29C64/106 ,  B29C64/112 ,  B29C64/118

公开(公告)号：EP1690091A1

公开(公告)日：2006-08-16

申请号：EP04805567.7

申请日：2004-11-26

申请人： Université Claude Bernard Lyon ,  CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS) ,  Institut National des Sciences Appliquées de Lyon

发明人： VOCANSON, Francis ,  LAMARTINE, Roger ,  DEBOUTTIERRE, Pierre-Jean ,  MARQUETTE, Christophe ,  BLUM, Loïc ,  ROUX, Stéphane ,  TILLEMENT, Olivier ,  PERRIAT, Pascal

IPC分类号： G01N33/543

CPC分类号： G01N33/54346 ,  B01J13/0043 ,  B82Y5/00 ,  C12Q1/6816 ,  C12Q2563/155

摘要： The invention relates to hybrid particle probes, comprising a nanoparticle of gold with a diameter in the range 2 to 30 nm with at least one, preferably 1 to 100 organic probe molecules and at least 10, preferably 10 to 10,000 molecules with luminescent activity, grafted to the surface thereof, by means of gold-sulphur bonds and a method for production thereof.

公开(公告)号：EP1723431B1

公开(公告)日：2012-09-05

申请号：EP05733006.0

申请日：2005-03-02

申请人： Université Claude Bernard Lyon I ,  CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS) ,  Institut National des Sciences Appliquées de Lyon

发明人： PERRIAT, Pascal ,  LOUIS, Cédric ,  MARQUETTE, Christophe ,  BAZZI, Rana ,  ROUX, Stéphane ,  TILLEMENT, Olivier ,  LEDOUX, Gilles

IPC分类号： G01N33/543 ,  G01N33/58 ,  G01N33/533 ,  G01N33/52 ,  G01N33/553 ,  A61K41/00 ,  A61K49/00 ,  A61K49/18 ,  C01F17/00 ,  B82Y30/00 ,  B82Y5/00 ,  C08L83/04 ,  A61K47/00

CPC分类号： G01N33/54346 ,  A61K41/009 ,  A61K49/0002 ,  A61K49/0093 ,  A61K49/1848 ,  A61K49/1857 ,  B82Y5/00 ,  B82Y30/00 ,  C01F17/0043 ,  C01P2002/52 ,  C01P2004/64 ,  G01N33/54353

公开(公告)号：EP1723431A1

公开(公告)日：2006-11-22

申请号：EP05733006.0

申请日：2005-03-02

申请人： Université Claude Bernard Lyon ,  CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS) ,  Institut National des Sciences Appliquées de Lyon

发明人： PERRIAT, Pascal ,  LOUIS, Cédric ,  MARQUETTE, Christophe ,  BAZZI, Rana ,  ROUX, Stéphane ,  TILLEMENT, Olivier ,  LEDOUX, Gilles

IPC分类号： G01N33/58 ,  G01N33/533 ,  G01N33/52 ,  G01N33/553

CPC分类号： G01N33/54346 ,  A61K41/009 ,  A61K49/0002 ,  A61K49/0093 ,  A61K49/1848 ,  A61K49/1857 ,  B82Y5/00 ,  B82Y30/00 ,  C01F17/0043 ,  C01P2002/52 ,  C01P2004/64 ,  G01N33/54353

摘要： Hybrid nanoparticles including a nanosphere with a mean diameter in the range 2-9 nm, of which at least 90 wt % consists of Ln2O3, where Ln is a rare earth optionally doped with a rare earth or an actinide, or a mixture of rare earths, or else a rare earth/actinide mixture in which at least 50 % of the metal ions are rare-earth ions; a coating around the nanosphere, of which a major part consists of a functionalised polysiloxane, and which has a mean thickness in the range 0.5-10 nm, preferably more than 2 nm but no more than 10 nm; and at least one bioligand grafted by a covalent bond to the polysiloxane coating; and a method for preparing same.

公开(公告)号：EP4141095A1

公开(公告)日：2023-03-01

申请号：EP21306143.5

申请日：2021-08-25

申请人： Sartorius Stedim FMT SAS ,  UNIVERSITE CLAUDE BERNARD - LYON 1 ,  Institut National des Sciences Appliquées de Lyon ,  Ecole Superieure de Chimie Physique Electronique de Lyon ,  Le Centre National de la Recherche Scientifique

发明人： CHASTAGNIER, Laura ,  PETIOT, Emma ,  COURTIAL, Edwin Geoffrey ,  MARQUETTE, Christophe

IPC分类号： C12M1/12 ,  C12M1/26 ,  B33Y70/10

摘要： Methods and systems for performing a bioproduction process are described, the bioproduction process comprising the production of a cellular product by a cell population. The methods include the steps of culturing the cell population at least partially embedded in a hydrogel matrix forming a three-dimensional structure.

公开(公告)号：EP4361944A1

公开(公告)日：2024-05-01

申请号：EP22306652.3

申请日：2022-10-31

申请人： Sartorius Stedim Data Analytics AB ,  UNIVERSITE CLAUDE BERNARD - LYON 1 ,  Institut National des Sciences Appliquées de Lyon ,  Ecole Superieure de Chimie Physique Electronique de Lyon ,  Centre national de la recherche scientifique

发明人： SJÖGREN, Rickard ,  REIF, Oscar-Werner ,  TRYGG, Johan ,  PETIOT, Emma ,  MARQUETTE, Christophe ,  CHASTAGNIER, Laura

IPC分类号： G06T7/00

CPC分类号： G06T7/0012 ,  G06T2207/1005620130101 ,  G06T2207/1008820130101 ,  G06T2207/2007620130101 ,  G06T2207/2008420130101 ,  G06T2207/3002420130101 ,  G06T2207/1006420130101

摘要： Methods for monitoring a process for producing multicellular structures from a cell population in a 3D cell culture are described. The methods comprise obtaining one or more 3D images of the 3D cell culture that are acquired by imaging the cell culture at different depths and/or from different angles, processing the one or more images to obtain a plurality of image-derived features, and determining the value of one or more metrics indicative of the progress or outcome of the maturation process using a statistical model adapted to predict the values of the one or more metrics indicative of the progress or outcome of the maturation process using inputs comprising the plurality of image-derived features. Related methods, systems and products are also described.