公开(公告)号：EP1208222A2

公开(公告)日：2002-05-29

申请号：EP00912055.1

申请日：2000-02-29

申请人： The University of Chicago

发明人： MIRZABEKOV, Andrei ,  GUSCHIN, Dmitry Y. ,  CHIK, Valentine ,  DROBYSHEV, Aleksei ,  FOTIN, Alexander ,  YERSHOV, Gennadiy ,  LYSOV, Yuri

IPC分类号： C12Q1/68

CPC分类号： C12Q1/6837 ,  B01J2219/00644 ,  C12Q1/6881 ,  C12Q1/6883 ,  C12Q1/689 ,  C12Q2600/156 ,  G06F19/20 ,  C12Q2565/607 ,  C12Q2565/513

摘要： This invention relates to using customized oligonucleotide microchips as biosensors for the detection and identification of the nucleic acids specific for different genes, organisms and/or individuals in the environment, in food and in biological samples. The microchips are designed to convert multiple bits of genetic information into simpler patterns of signals that are interpreted as a unit. Because of an improved method of hybridizing oligonucleotides from samples to microchips, microchips are reusable and transportable. For field study, portable laser or bar code scanners are suitable.

公开(公告)号：EP0951569A2

公开(公告)日：1999-10-27

申请号：EP97953408.0

申请日：1997-12-19

申请人： UNIVERSITY OF CHICAGO

发明人： MIRZABEKOV, Andrei ,  GUSCHIN, Dmitry Y. ,  Shik, Valentine ,  FOTIN, Alexander ,  YERSHOV, Gennadiy ,  LYSOV, Yu

IPC分类号： C12Q1

CPC分类号： C12Q1/689 ,  C12Q1/6837 ,  C12Q1/6881 ,  C12Q1/6883 ,  C12Q2600/156 ,  C12Q2565/513

摘要： Biosensors are constructed using customized micromatrices to design a microship. The microchip contains an arrangement of oligonucleotides designed to provide information on oligonucleotide sequences in a sample to be tested by the ability of the oligonucleotides in the nucleic acid sample to hybridize with oligonucleotides on the microchip. Biosensors are used to detect microorganisms in the environment, in biological samples and in food. Biosensors are also used to diagnose genetic defects, to identify polymorphisms, and to monitor quantitative gene expression.