公开(公告)号：EP0782864A1

公开(公告)日：1997-07-09

申请号：EP97102864.2

申请日：1991-09-20

申请人： UNIVERSITY OF FLORIDA

发明人： Goldberg, Eugene P. ,  Burns, James W. ,  Kamar, Sudesh G. ,  Osborn, David C. ,  Larson, Jeffrey A. ,  Sheets, John W. ,  Yahiaoui, Ali ,  Robinson, Richard

IPC分类号： A61L27/00 ,  A61L33/00

CPC分类号： G02B1/043 ,  A61F2/16 ,  A61F2002/009 ,  A61L27/16 ,  A61L33/0088 ,  A61L2400/18 ,  A61L2430/16 ,  C08J7/18 ,  C08L33/14 ,  C08L39/06 ,  Y10S623/921 ,  C08L51/06

摘要： A method is disclosed for modifying a plastic surface of ocular implants, said surface adapted for contact with living tissue of a human or non-human animal, by the gamma-irradiation induced or the electron beam-irradiation induced polymerized chemically grafted coating thereon of:

1) a monomer comprising N-vinylpyrrolidone (NVP),
2) a monomer comprising 2-hydroxyethyl-methacrylate (HEMA),
3) a mixture of (NVP) and (HEMA), (NVP-HEMA), or
4) a mixture of 1), 2) or 3) with up to about 50 wt%, based on the total monomer weight, of an ionic monomer, salt of an ionic monomer or mixture thereof; so as to form a hydrophillic graft polymer coating of:

I. polyvinylpyrrolidone (PVP),
II. poly-2-hydroxyethylmethacrylate (PHEMA),
III. a copolymer of (NVP) and (HEMA), [P(NVP-HEMA)], or
IV. a copolymer of (NVP), (HEMA), or (NVP-HEMA) and said ionic monomer, on said surface, the improvement comprising:

   conducting said gamma-irradiation induced graft polymerisation in an aqueous solution under the following conditions:

a) monomer concentration in the range of from about 0.1% to about 50% by weight;
b) total gamma (or total electron beam irradiation) dose in the range of from about 0.001 to less than about 0.50 Mrad; and
c) gamma dose rate in the range of from about 10 to about 2500 rads/min or an electron beam irradiation dose rate in the range of from about 10 to about 10 8 rads/min.

摘要翻译： 公开了一种用于修改眼部植入物的塑料表面的方法，所述表面适于与人或非人动物的活组织接触，通过γ照射诱导或电子束照射诱导其聚合的化学接枝涂层： 1）包含N-乙烯基吡咯烷酮（NVP）的单体，2）包含2-羟乙基 - 甲基丙烯酸酯（HEMA）的单体，3）（NVP）和（HEMA），（NVP-HEMA）的混合物，或4）混合物 1），2）或3）具有高达约50重量％的离子单体，离子单体的盐或其混合物的总单体重量; 从而形成亲水接枝聚合物涂层：I.聚乙烯吡咯烷酮（PVP），II。 聚甲基丙烯酸2-羟基乙酯（PHEMA），III。 （NVP）和（HEMA），ÄP（NVP-HEMA）Ü或IV的共聚物。 在所述表面上的（NVP），（HEMA）或（NVP-HEMA）或（NVP-HEMA）或所述离子单体的共聚物的改进包括：在以下条件下，在水溶液中进行所述γ射线诱导的接枝聚合：a）单体 浓度在约0.1％至约50％重​​量的范围内; b）总伽马（或总电子束照射）剂量在约0.001至小于约0.50Mrad范围内; 和c）约10至约2500rad / min范围内的γ剂量率或约10至约10弧度/分钟范围内的电子束照射剂量率。