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    Improved ocular implants and methods for their manufacture
    2.
    发明公开
    Improved ocular implants and methods for their manufacture 失效
    Okulares Implantat und Verfahren zu seiner Herstellung。

    公开(公告)号：EP0286433A2

    公开(公告)日：1988-10-12

    申请号：EP88303172.6

    申请日：1988-04-08

    申请人： UNIVERSITY OF FLORIDA

    发明人： Goldberg, Eugene P. Dept. Materials Science ,  Osborn, David C. ,  Kumar, Sudesh, G. ,  Larson, Jeffrey A. ,  Sheets, John W. ,  Burns, James W.

    IPC分类号： A61L27/00 ,  A61F2/16 ,  C08J7/18

    CPC分类号： A61L27/50 ,  A61F2/14 ,  A61F2002/16903 ,  A61L27/16 ,  A61L2400/18 ,  A61L2430/16 ,  C08J7/18 ,  A61F2/16 ,  C08L51/06

    摘要： A method for modifying a PMMA surface by the gamma-irradiation induced polymerization thereon of N-­vinylpyrrolidone, 2-hydroxyethylmethacrylate or a mixture thereof while maintaining the following conditions:

    a) monomer concentration in the range of from about 0.5% to about 50%, by weight;
    b) total gamma dose in the range of from about 0.01 to less than about 0.50 Mrad;
    c) gamma dose rate in the range of from about 10 to about 2500 rads/minute; and
    d) maintaining the molecular weight of the polymer in solution in the range of from about 250,000 to about 5,000,000.

    The invention also relates to modifying polypropylene, polyvinylidene fluoride, polycarbonate and silicone surfaces according to a similar method as well as materials produced by the above methods which are useful as ocular implants.

    摘要翻译： 通过γ-射线诱导聚合在其上的N-乙烯基吡咯烷酮，甲基丙烯酸2-羟基乙酯或其混合物来改性PMMA表面的方法，同时保持以下条件：a）单体浓度在约0.5％至约50％的范围内， 重量 b）在约0.01至小于约0.5Mrad范围内的总γ剂量; c）γ剂量率在约10至约2500rad /分钟的范围内; 和d）将聚合物在溶液中的分子量保持在约250,000至约5,000,000的范围内。 本发明还涉及根据类似方法改性聚丙烯，聚偏二氟乙烯，聚碳酸酯和硅氧烷表面，以及用作眼睛植入物的上述方法制备的材料。

    Surface modified ocular implants, contacts lenses and the like
    3.
    发明公开
    Surface modified ocular implants, contacts lenses and the like 失效
    Oberflächenmodifizierte Augenimplantate，Kontaktlinsen und dergleichen

    公开(公告)号：EP0782864A1

    公开(公告)日：1997-07-09

    申请号：EP97102864.2

    申请日：1991-09-20

    申请人： UNIVERSITY OF FLORIDA

    发明人： Goldberg, Eugene P. ,  Burns, James W. ,  Kamar, Sudesh G. ,  Osborn, David C. ,  Larson, Jeffrey A. ,  Sheets, John W. ,  Yahiaoui, Ali ,  Robinson, Richard

    IPC分类号： A61L27/00 ,  A61L33/00

    CPC分类号： G02B1/043 ,  A61F2/16 ,  A61F2002/009 ,  A61L27/16 ,  A61L33/0088 ,  A61L2400/18 ,  A61L2430/16 ,  C08J7/18 ,  C08L33/14 ,  C08L39/06 ,  Y10S623/921 ,  C08L51/06

    摘要： A method is disclosed for modifying a plastic surface of ocular implants, said surface adapted for contact with living tissue of a human or non-human animal, by the gamma-irradiation induced or the electron beam-irradiation induced polymerized chemically grafted coating thereon of:

    1) a monomer comprising N-vinylpyrrolidone (NVP),
    2) a monomer comprising 2-hydroxyethyl-methacrylate (HEMA),
    3) a mixture of (NVP) and (HEMA), (NVP-HEMA), or
    4) a mixture of 1), 2) or 3) with up to about 50 wt%, based on the total monomer weight, of an ionic monomer, salt of an ionic monomer or mixture thereof; so as to form a hydrophillic graft polymer coating of:

    I. polyvinylpyrrolidone (PVP),
    II. poly-2-hydroxyethylmethacrylate (PHEMA),
    III. a copolymer of (NVP) and (HEMA), [P(NVP-HEMA)], or
    IV. a copolymer of (NVP), (HEMA), or (NVP-HEMA) and said ionic monomer, on said surface, the improvement comprising:

       conducting said gamma-irradiation induced graft polymerisation in an aqueous solution under the following conditions:

    a) monomer concentration in the range of from about 0.1% to about 50% by weight;
    b) total gamma (or total electron beam irradiation) dose in the range of from about 0.001 to less than about 0.50 Mrad; and
    c) gamma dose rate in the range of from about 10 to about 2500 rads/min or an electron beam irradiation dose rate in the range of from about 10 to about 10 8 rads/min.

    摘要翻译： 公开了一种用于修改眼部植入物的塑料表面的方法，所述表面适于与人或非人动物的活组织接触，通过γ照射诱导或电子束照射诱导其聚合的化学接枝涂层： 1）包含N-乙烯基吡咯烷酮（NVP）的单体，2）包含2-羟乙基 - 甲基丙烯酸酯（HEMA）的单体，3）（NVP）和（HEMA），（NVP-HEMA）的混合物，或4）混合物 1），2）或3）具有高达约50重量％的离子单体，离子单体的盐或其混合物的总单体重量; 从而形成亲水接枝聚合物涂层：I.聚乙烯吡咯烷酮（PVP），II。 聚甲基丙烯酸2-羟基乙酯（PHEMA），III。 （NVP）和（HEMA），ÄP（NVP-HEMA）Ü或IV的共聚物。 在所述表面上的（NVP），（HEMA）或（NVP-HEMA）或（NVP-HEMA）或所述离子单体的共聚物的改进包括：在以下条件下，在水溶液中进行所述γ射线诱导的接枝聚合：a）单体 浓度在约0.1％至约50％重​​量的范围内; b）总伽马（或总电子束照射）剂量在约0.001至小于约0.50Mrad范围内; 和c）约10至约2500rad / min范围内的γ剂量率或约10至约10弧度/分钟范围内的电子束照射剂量率。