公开(公告)号：EP1488791A3

公开(公告)日：2005-04-06

申请号：EP04077214.7

申请日：1999-09-21

申请人： UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INC. ,  The Trustees of Columbia University in the City of New York Engineering Terrace Room 363

发明人： Bergeron, Raymond J ,  Brittenham, Gary M

IPC分类号： A61K31/44 ,  A61K31/47 ,  C07C43/23 ,  C07C43/178 ,  C07D417/04 ,  C07D277/12

CPC分类号： A61K31/4439 ,  A61K31/40 ,  A61K31/4164 ,  A61K31/426 ,  A61K31/4436 ,  Y02A50/411

摘要： Composition, article of manufacture for and method of treating malaria in a human having an infestation of Plasmodium protozoans are described. The method comprises administering a therapeutically effective amount of a compound of formula (I) or (IV), i.e., sufficient quantity to reduce the population of Plasmodium. The composition of the invention is a compound of formula (I) or (IV) with a pharmaceutical excipient. The article of manufacture is the composition in combination with labelling for treating malaria. The substituents are detailed in the specification.

公开(公告)号：EP1488791A2

公开(公告)日：2004-12-22

申请号：EP04077214.7

申请日：1999-09-21

申请人： UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INC. ,  The Trustees of Columbia University in the City of New York Engineering Terrace Room 363

发明人： Bergeron, Raymond J ,  Brittenham, Gary M

IPC分类号： A61K31/44 ,  A61K31/47 ,  C07C43/23 ,  C07C43/178 ,  C07D417/04 ,  C07D277/12

CPC分类号： A61K31/4439 ,  A61K31/40 ,  A61K31/4164 ,  A61K31/426 ,  A61K31/4436 ,  Y02A50/411

摘要： Composition, article of manufacture for and method of treating malaria in a human having an infestation of Plasmodium protozoans are described. The method comprises administering a therapeutically effective amount of a compound of formula (I) or (IV), i.e., sufficient quantity to reduce the population of Plasmodium. The composition of the invention is a compound of formula (I) or (IV) with a pharmaceutical excipient. The article of manufacture is the composition in combination with labelling for treating malaria. The substituents are detailed in the specification.

摘要翻译： 描述了具有侵染疟原虫原虫的人的组合物，制品和治疗疟疾的方法。 该方法包括施用治疗有效量的式（I）或（IV）化合物，即足够的量以减少疟原虫群体。 本发明的组合物是具有药物赋形剂的式（I）或（IV）的化合物。 制品是与疟疾治疗标签相结合的组合物。 取代基在说明书中详细描述。