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公开(公告)号：EP1996214A2
公开(公告)日：2008-12-03
申请号：EP07750725.9
申请日：2007-02-13
申请人： University of Iowa Research Foundation , The Trustees of Columbia University in the City of New York , National Institutes of Health, DHHS
IPC分类号： A61K38/00
CPC分类号： A61K38/1709
摘要： Methods for identifying a subject at risk for developing AMD are disclosed. The methods include identifying specific protective or risk polymorphisms or genotypes from the subject's genetic material. Therapeutic compositions and methods are also provided for delaying the progression or onset of the development of AMD in a subject, including treating a subject having signs and/or symptoms of AMD or who has been diagnosed with AMD.
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公开(公告)号：EP1153302A1
公开(公告)日：2001-11-14
申请号：EP00915845.2
申请日：2000-02-22
发明人： HAGEMAN, Gregory, S.
IPC分类号： G01N33/68
CPC分类号： G01N33/6893 , C12Q1/6883 , C12Q2600/158 , G01N2333/78 , G01N2800/164 , G01N2800/329
摘要： The invention relates to diagnostics and therapeutics and animal models for macular degeneration, specifically as they relate to the association described herein between macular degeneration and arterial wall disruptive disorders. In one embodiment, the invention provides kits and methods for diagnosing macular degeneration comprising identifying a marker for an arterial wall disruptive disorder, including an aneurysm. In one emdodiment, the invention provides therapeutics for treating macular degeneration comprising delivering to a subject an agent useful for treating an arterial wall disruptive disorder, including an aneurysm.
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3.发明授权
公开(公告)号：EP1996214B1
公开(公告)日：2016-05-04
申请号：EP07750725.9
申请日：2007-02-13
申请人： University of Iowa Research Foundation , The Trustees of Columbia University in the City of New York , National Institutes of Health, DHHS
IPC分类号： C12Q1/68
CPC分类号： A61K38/1709
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公开(公告)号：EP1161686A2
公开(公告)日：2001-12-12
申请号：EP00912189.8
申请日：2000-03-06
IPC分类号： G01N33/68
CPC分类号： C12Q1/6883 , C12Q2600/158 , G01N33/6893 , G01N2800/164
摘要： The invention relates to methods for treating, preventing and diagnosing drusen-associated disorders.
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5.发明授权
公开(公告)号：EP1287364B1
公开(公告)日：2008-10-22
申请号：EP01934962.0
申请日：2001-04-30
IPC分类号： G01N33/68
CPC分类号： G01N33/6893 , A61K38/00 , A61K47/46 , A61K51/10 , C12Q1/6883 , C12Q2600/158 , G01N33/564 , G01N33/6896 , G01N2333/4716 , G01N2800/164
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公开(公告)号：EP1937706A2
公开(公告)日：2008-07-02
申请号：EP06813703.3
申请日：2006-08-23
发明人： HAGEMAN, Gregory, S.
CPC分类号： G01N33/6893 , C12Q1/6883 , C12Q2600/156 , G01N2800/164 , G01N2800/52 , G01N2800/7042
摘要： The invention relates to proteins associated with age-related macular degeneration (AMD). These proteins, which are present in blood, are expressed in individuals with AMD at either elevated or reduced levels compared to healthy individuals. The invention provides methods for diagnosing AMD. The invention provides methods for assessing the efficacy of treatment of AMD. The invention provides methods for monitoring the progression of AMD.
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公开(公告)号：EP1153301A1
公开(公告)日：2001-11-14
申请号：EP00915841.1
申请日：2000-02-22
发明人： HAGEMAN, Gregory, S.
IPC分类号： G01N33/68
CPC分类号： G01N33/6893 , C12Q1/6883 , C12Q2600/158 , G01N2333/78 , G01N2800/164 , G01N2800/329
摘要： The invention provides diagnostics, therapeutics and drug screening assays for arterial wall disruptive disorders, based on the discovery of a high level of correlation between the incidence of arterial wall disruptive disorders and the incidence of Age Related Macular Degeneration (AMD). In one embodiment, the arterial wall disruptive disorder is an aortic aneurysm.
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8.发明公开VARIANTS IN COMPLEMENT REGULATORY GENES PREDICT AGE-RELATED MACULAR DEGENERATION 审中-公开变异互补调节基因与预期相符年龄相关性黄斑变性
公开(公告)号：EP1989319A2
公开(公告)日：2008-11-12
申请号：EP07750527.9
申请日：2007-02-13
申请人： University of iowa research foundation , The Trustees of Columbia University in the City of New York , NATIONAL INSTITUTES OF HEALTH
CPC分类号： C12Q1/6883 , C12Q2600/112 , C12Q2600/118 , C12Q2600/156 , C12Q2600/158 , C12Q2600/172
摘要： Methods for identifying a subject at risk for developing AMD are disclosed, as are kits which can be used to practice the methods. The methods include identifying specific protective or risk polymorphisms or genotypes from the subject's genetic material, including polymorphisms in the BF, C2 and/or CFH genes. Microarrays and kits for use in these methods are also provided.
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公开(公告)号：EP1153302B1
公开(公告)日：2006-10-25
申请号：EP00915845.2
申请日：2000-02-22
发明人： HAGEMAN, Gregory, S.
IPC分类号： G01N33/68
CPC分类号： G01N33/6893 , C12Q1/6883 , C12Q2600/158 , G01N2333/78 , G01N2800/164 , G01N2800/329
摘要： The invention relates to diagnostics and therapeutics and animal models for macular degeneration, specifically as they relate to the association described herein between macular degeneration and arterial wall disruptive disorders. In one embodiment, the invention provides kits and methods for diagnosing macular degeneration comprising identifying a marker for an arterial wall disruptive disorder, including an aneurysm. In one emdodiment, the invention provides therapeutics for treating macular degeneration comprising delivering to a subject an agent useful for treating an arterial wall disruptive disorder, including an aneurysm.
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公开(公告)号：EP1287364A2
公开(公告)日：2003-03-05
申请号：EP01934962.0
申请日：2001-04-30
IPC分类号： G01N33/68
CPC分类号： G01N33/6893 , A61K38/00 , A61K47/46 , A61K51/10 , C12Q1/6883 , C12Q2600/158 , G01N33/564 , G01N33/6896 , G01N2333/4716 , G01N2800/164
摘要： The invention relates to methods for treating, preventing and diagnosing macular degeneration-related disorders.
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