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    METHODS FOR TREATING CONDITIONS ASSOCIATED WITH MASP-2 DEPENDENT COMPLEMENT ACTIVATION
    1.
    发明公开
    METHODS FOR TREATING CONDITIONS ASSOCIATED WITH MASP-2 DEPENDENT COMPLEMENT ACTIVATION 审中-公开
    治疗与MASP-2依赖性补体活化有关的病症的方法

    公开(公告)号：EP3067067A1

    公开(公告)日：2016-09-14

    申请号：EP16164436.4

    申请日：2007-03-27

    申请人： UNIVERSITY OF LEICESTER ,  Omeros Corporation

    发明人： SCHWAEBLE, Hans-Wilhelm ,  STOVER, Cordula Margaret ,  TEDFORD, Clark E. ,  PARENT, James B. ,  FUJITA, Teizo

    IPC分类号： A61K39/395 ,  C07K16/40 ,  C07K14/47 ,  A01K67/027

    摘要： In one aspect, the disclosure provides methods of inhibiting the effects of MASP-2-dependent complement activation in a living subject. The methods comprise the step of administering, to a subject in need thereof, an amount of a MASP-2 inhibitory agent effective to inhibit MASP-2-dependent complement activation. In some embodiments, the MASP-2 inhibitory agent inhibits cellular injury associated with MASP-2-mediated alternative complement pathway activation, while leaving the classical (Clq-dependent) pathway component of the immune system intact. In another aspect, the disclosure provides compositions for inhibiting the effects of lectin-dependent complement activation, comprising a therapeutically effective amount of a MASP-2 inhibitory agent and a pharmaceutically acceptable carrier.

    摘要翻译： 在一个方面，本公开提供了抑制活体中MASP-2依赖性补体活化作用的方法。 该方法包括向有需要的受试者施用有效抑制MASP-2依赖性补体激活的量的MASP-2抑制剂的步骤。 在一些实施方案中，MASP-2抑制剂抑制与MASP-2介导的替代补体途径活化相关的细胞损伤，同时保持免疫系统的经典（Clq依赖性）途径组分完整。 另一方面，本公开提供了用于抑制凝集素依赖性补体活化作用的组合物，其包含治疗有效量的MASP-2抑制剂和药学上可接受的载体。