公开(公告)号：EP0755259B1

公开(公告)日：2005-08-03

申请号：EP95914198.7

申请日：1995-03-29

申请人： UNIVERSITY OF MARYLAND COLLEGE PARK

发明人： VAKHARIA, Vikram ,  SNYDER, David B. ,  MENGEL-WHERSAT, Stephanie A.

IPC分类号： A61K35/76 ,  A61K39/12 ,  A61K39/395 ,  C07K14/005 ,  C07K16/08 ,  C12N1/21 ,  C12N5/10 ,  C12N15/33

CPC分类号： C07K14/005 ,  A61K38/00 ,  A61K39/00 ,  C07K16/08 ,  C12N2720/10022

摘要： Chimeric cDNA for the expression of immunogenic polypeptides include the genetic epitopic determinants for a base infectious bursal disease virus strain and at least one other infectious bursal disease virus strain. The genetic epitopic determinants encode amino acids or amino acid sequences which define epitopes bound to by previously established monoclonal antibodies. The immunogens expressed by the cDNA may be employed to provide a vaccine against a plurality of IBDV strains. The epitopic determinant of IBDV lethal strains has been detected, and an immunogen for conferring immunity with respect thereto is disclosed. Similarly, a monoclonal antibody specific for IBDV lethal strains is identified, and a vaccine for passive immunization therewith is also disclosed. Immunogens exhibiting conformational epitopes, in the form of virus-like particles, are effective in the preparation of vaccines.

公开(公告)号：EP0621790A1

公开(公告)日：1994-11-02

申请号：EP93920360.0

申请日：1993-09-01

申请人： UNIVERSITY OF MARYLAND COLLEGE PARK

发明人： SNYDER, David, B. ,  VAKHARIA, Vikram ,  LUETTICKEN, Heinrich, Dieter

IPC分类号： A61K39 ,  A61P31 ,  C07K14 ,  C07K16 ,  C12N7 ,  C12N15 ,  C12P21 ,  A61K38

CPC分类号： C07K14/005 ,  A61K38/00 ,  A61K39/00 ,  C07K16/08 ,  C12N2720/10022 ,  C12N2720/10034 ,  C12N2720/10061

摘要： On détecte l'efficacité de virus vivants et affaiblis de la maladie infectieuse des bourses, appartenant à la souche de Delaware, en utilisant un anticorps monoclonal spécifique à ladite souche. Ceux qui ne sont pas liés par l'anticorps ne confèrent pas, ou peuvent ne pas conférer, une protection aussi efficace contre l'infection par la maladie infectieuse des bourses de phénotype sauvage homologue. Les vaccins vivants et affaiblis actuellement disponibles ne comprennent pas un virus présentant le site de liaison spécifique. Un anticorps monoclonal spécifique à la souche de Delaware permet également d'obtenir un vaccin destiné à une immunisation passive.

公开(公告)号：EP0755259A1

公开(公告)日：1997-01-29

申请号：EP95914198.0

申请日：1995-03-29

申请人： UNIVERSITY OF MARYLAND COLLEGE PARK

发明人： VAKHARIA, Vikram ,  SNYDER, David B. ,  MENGEL-WHERSAT, Stephanie A.

IPC分类号： C12N15 ,  A61K35 ,  A61K38 ,  A61K39 ,  A61K48 ,  A61P31 ,  A61P43 ,  C07H21 ,  C07K14 ,  C07K16 ,  C07K19 ,  C12N7 ,  C12P21

CPC分类号： C07K14/005 ,  A61K38/00 ,  A61K39/00 ,  C07K16/08 ,  C12N2720/10022

摘要： Chimeric cDNA for the expression of immunogenic polypeptides include the genetic epitopic determinants for a base infectious bursal disease virus strain and at least one other infectious bursal disease virus strain. The genetic epitopic determinants encode amino acids or amino acid sequences which define epitopes bound to by previously established monoclonal antibodies. The immunogens expressed by the cDNA may be employed to provide a vaccine against a plurality of IBDV strains. The epitopic determinant of IBDV lethal strains has been detected, and an immunogen for conferring immunity with respect thereto is disclosed. Similarly, a monoclonal antibody specific for IBDV lethal strains is identified, and a vaccine for passive immunization therewith is also disclosed. Immunogens exhibiting conformational epitopes, in the form of virus-like particles, are effective in the preparation of vaccines.