公开(公告)号：EP2686011A2

公开(公告)日：2014-01-22

申请号：EP12725287.2

申请日：2012-03-14

申请人： FVG Limited

发明人： EVENSEN, Øystein ,  RITCHIE, Gordon ,  JØSSUND, Trude Bakke ,  MUTOLOKI, Stephen

IPC分类号： A61K39/12

CPC分类号： C12N7/00 ,  A61K39/12 ,  A61K2039/5254 ,  A61K2039/54 ,  A61K2039/552 ,  C12N2720/10021 ,  C12N2720/10022 ,  C12N2720/10034

摘要： The present invention relates to a live avirulent infectious pancreatic necrosis virus which has been shown to be genetically stable in biological studies. Fish exposed to said virus turn out positive for the virus without showing any signs of disease and the avirulent virus has also been shown to protect the fish against IPN for an extended period of time after administration. Thus, a vaccine comprising said virus and said virus for the prophylaxis or treatment of infectious pancreatic necrosis disease are also part of the present invention.

摘要翻译： 本发明涉及在生物学研究中已被证明在遗传上稳定的无活性毒素感染性胰腺坏死病毒。 暴露于所述病毒的鱼对病毒呈阳性，没有出现任何疾病迹象，无毒素病毒也被证明可以在施用后长时间保护鱼类免受IPN的侵袭。 因此，包含所述病毒和所述病毒用于预防或治疗感染性胰腺坏死病的疫苗也是本发明的一部分。

公开(公告)号：EP2497494A2

公开(公告)日：2012-09-12

申请号：EP10809153.9

申请日：2010-11-05

申请人： Chimera Pharma, S. L. U.

发明人： ZURCHER, Thomas ,  VON KOBBE, Cayetano ,  BERNAL, Juan José ,  JIMENEZ TORRES, Ignacio ,  CALDERITA LUCAS, Gloria ,  RODRIGUEZ GARCIA, Margarita ,  GARZON GUTIERREZ, Ana ,  GONDAR SOUSA E SILVA, Virginia ,  GARCIA DE CASTRO, Arcadio ,  PINO DE LA HUERGA, Irene

IPC分类号： A61K39/12

CPC分类号： C12N7/00 ,  A61K39/12 ,  A61K2039/5258 ,  A61K2039/585 ,  C07K14/005 ,  C07K2319/00 ,  C12N2710/20022 ,  C12N2710/20023 ,  C12N2710/20034 ,  C12N2720/10022 ,  C12N2720/10023

摘要： The invention relates to therapeutic vaccines for treating neoplasias caused by the human papillomavirus (HPV). The vaccines according to the invention are especially formed by chimeric pseudo-viral capsids of birnavirus containing papillomavirus antigens.

摘要翻译： 本发明涉及用于治疗由人乳头瘤病毒（HPV）引起的肿瘤的治疗性疫苗。 根据本发明的疫苗特别由含有乳头瘤病毒抗原的双鞭毛病毒的嵌合假病毒衣壳形成。

公开(公告)号：EP1743652B1

公开(公告)日：2011-11-16

申请号：EP06122758.3

申请日：2003-08-14

申请人： Pfizer Products Inc.

发明人： Dominowski, Paul Joseph

IPC分类号： A61K39/295 ,  A61K39/12 ,  A61K39/155 ,  A61K39/02 ,  A61K39/265 ,  A61K39/39

CPC分类号： A61K39/295 ,  A61K39/00 ,  A61K39/0225 ,  A61K39/39 ,  A61K2039/5252 ,  A61K2039/5254 ,  C07K14/005 ,  C12N2710/16722 ,  C12N2720/10022 ,  C12N2760/18522 ,  C12N2760/18622 ,  C12N2770/24322 ,  C12N2770/28022

公开(公告)号：EP1334197B1

公开(公告)日：2011-01-05

申请号：EP01980767.6

申请日：2001-11-12

申请人： The University Court of The University of Aberdeen

发明人： MELVIN, William, Thomas ,  BREEMAN, Suzanne ,  LABUS, Marie, Beagley

IPC分类号： C12N15/40 ,  A61K39/12 ,  C12N15/81 ,  C07K14/08 ,  A61K39/39 ,  A61P31/12 ,  C12N1/19 ,  A61K39/295

CPC分类号： C07K14/005 ,  A61K2039/525 ,  C12N2720/10022

摘要： Disclosed are processes for producing a vaccine for use against infectious pancreatic necrosis virus (IPNV) in fish, which process comprises culturing a yeast host cell which expresses, and preferably secretes, an IPNV polypeptide, and formulating the polypeptide as a vaccine (preferably by using, or partially purifying) the supernatant. Such vaccines have advantages over vaccines produced in bacteria. Also disclosed are vaccines based VP3 and VP2var proteins, optionally in combination with antigens protective against other fish diseases. The invention further provides related materials (e.g. primers, vectors and host cells) and methods and uses of the vaccines for prophylaxis and therapy.

公开(公告)号：EP2254993A1

公开(公告)日：2010-12-01

申请号：EP09712586.8

申请日：2009-02-19

申请人： Kapsid Link, S.L.

发明人： RODRÍGUEZ AGUIRRE, José Francisco ,  OÑA BLANCO, Ana María

IPC分类号： C12N7/04 ,  C07K14/08 ,  C12N15/62

CPC分类号： C12N7/00 ,  A61K2039/5258 ,  C07K14/005 ,  C07K2319/20 ,  C07K2319/33 ,  C07K2319/735 ,  C07K2319/74 ,  C07K2319/90 ,  C12N2720/10022 ,  C12N2720/10023

摘要： The invention relates to nanocarriers formed by protein assemblies, obtained by means of the assembly of a genetically modified self assembly protein in order to couple products of interest bound to a ligand. These protein nanocarriers can be used as a system for carrying and presenting products of interest.

公开(公告)号：EP1626694A4

公开(公告)日：2008-01-23

申请号：EP04751354

申请日：2004-05-06

申请人： SCHWEITZER CHEMICAL CORP LTD

发明人： KUO TSUN-YUNG

IPC分类号： A61K39/12 ,  C12N15/09 ,  A61K20060101 ,  A61K35/76 ,  A61K39/00 ,  A61K39/295 ,  A61K39/39 ,  A61K48/00 ,  A61P31/12 ,  C07K14/055 ,  C07K14/08 ,  C07K14/125 ,  C07K14/165

CPC分类号： A61K39/12 ,  A61K2039/53 ,  A61K2039/54 ,  A61K2039/545 ,  A61K2039/55 ,  A61K2039/552 ,  A61K2039/70 ,  C07K14/005 ,  C12N2710/16322 ,  C12N2710/16334 ,  C12N2720/10022 ,  C12N2720/10034 ,  C12N2760/18122 ,  C12N2760/18134 ,  C12N2770/20022 ,  C12N2770/20034

公开(公告)号：EP1706485B1

公开(公告)日：2007-09-26

申请号：EP05706999.9

申请日：2005-01-21

申请人： CONSEJO SUPERIOR DE INVESTIGACIONES CIENTIFICAS ,  Bionostra S.L.

发明人： RODRIGUEZ AGUIRRE, José Francisco ,  RUIZ CASTÓN, José ,  GONZÁLEZ DE LLANO, María Dolores ,  OÑA BLANCO, Ana María ,  ABAITUA ELUSTONDO, Fernando ,  LUQUE BUZO, Daniel ,  RODRIGUEZ FERNANDEZ-ALBA, Juan Ramón

IPC分类号： C12N7/04 ,  A61K39/12 ,  C12N15/62 ,  C07K14/08 ,  C07K19/00 ,  C12N15/87 ,  C12N15/86 ,  C12N5/10

CPC分类号： C12N7/00 ,  A61K2039/5258 ,  C07K14/005 ,  C12N2720/10022 ,  C12N2720/10023

摘要： The empty capsids of the infectious bursal disease virus (IBDV), VLP(-VP4), are characterized in that they are constituted only by assembly of IBDV pVP2 proteins and IBDV VP3 proteins. Said capsids have immunogenic activity and can be used in the manufacture of vaccines for protecting animals from the infection caused by IBDV, as well as in the manufacture of gene therapy vectors.

公开(公告)号：EP1334197A1

公开(公告)日：2003-08-13

申请号：EP01980767.6

申请日：2001-11-12

申请人： The University Court of The University of Aberdeen

发明人： MELVIN, William, Thomas ,  BREEMAN, Suzanne ,  LABUS, Marie, Beagley

IPC分类号： C12N15/40 ,  A61K39/12 ,  C12N15/81 ,  C07K14/08 ,  A61K39/39 ,  A61P31/12 ,  C12N1/19 ,  A61K39/295

CPC分类号： C07K14/005 ,  A61K2039/525 ,  C12N2720/10022

摘要： Disclosed are processes for producing a vaccine for use against infectious pancreatic necrosis virus (IPNV) in fish, which process comprises culturing a yeast host cell which expresses, and preferably secretes, an IPNV polypeptide, and formulating the polypeptide as a vaccine (preferably by using, or partially purifying) the supernatant. Such vaccines have advantages over vaccines produced in bacteria. Also disclosed are vaccines based VP3 and VP2var proteins, optionally in combination with antigens protective against other fish diseases. The invention further provides related materials (e.g. primers, vectors and host cells) and methods and uses of the vaccines for prophylaxis and therapy.

公开(公告)号：EP0712926A3

公开(公告)日：1996-07-03

申请号：EP95202771.2

申请日：1995-10-13

申请人： Akzo Nobel N.V.

发明人： McLoughlin, Marian F. ,  Nelson, Robert Thomas

IPC分类号： C12N7/00 ,  C07K14/18 ,  C12N15/40 ,  C12N7/02 ,  A61K39/12 ,  G01N33/48

CPC分类号： C07K14/005 ,  A61K38/00 ,  A61K39/00 ,  A61K39/12 ,  A61K2039/5252 ,  A61K2039/552 ,  C12N7/00 ,  C12N2720/10022 ,  C12N2720/10034 ,  C12N2770/36022 ,  C12N2770/36121 ,  C12N2770/36122 ,  C12N2770/36134 ,  G01N33/56983

摘要： There is described a novel virus which is the causative agent of fish pancreatic disease, which is a serious disease affecting Atlantic salmon. A method of isolating the virus through co-cultivation of infected tissues following by passage is described and an isolated strain of the virus has been deposited. The use of the virus, or proteins or polypeptide derived therefrom as a vaccine or in diagnosis is described, together with genetically engineered constructs.

摘要翻译： 描述了一种新型病毒，它是鱼类胰腺疾病的病原体，它是影响大西洋鲑鱼的严重疾病。 描述了通过随后通过共同培养受感染组织来分离病毒的方法，并且已经沉积了病毒的分离株。 描述了该病毒或由其衍生的蛋白质或多肽作为疫苗或用于诊断的用途，以及基因工程构建体。

公开(公告)号：EP0428596A4

公开(公告)日：1991-09-04

申请号：EP89909303

申请日：1989-08-02

申请人： UNIVERSITY OF MARYLAND

发明人： SNYDER, DAVID, B.

IPC分类号： C12P21/08 ,  A61K38/00 ,  A61K39/00 ,  A61K39/12 ,  A61P31/12 ,  C07K14/08 ,  C07K16/08 ,  C12N7/00 ,  C12Q1/70 ,  C12R1/91 ,  G01N33/569 ,  G01N33/577 ,  A01H5/02

CPC分类号： C07K14/005 ,  A61K38/00 ,  A61K39/00 ,  C07K16/08 ,  C12N2720/10022 ,  Y10S424/816