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    HYBRIDIZATION AND FOOTPRINTING METHODS TO CHARACTERIZE THE INTERACTIONS OF 16S rRNA ANALOGUES FOR IDENTIFICATION OF NOVEL ANTIBIOTICS
    1.
    发明授权
    HYBRIDIZATION AND FOOTPRINTING METHODS TO CHARACTERIZE THE INTERACTIONS OF 16S rRNA ANALOGUES FOR IDENTIFICATION OF NOVEL ANTIBIOTICS 失效
    杂交和施加过程表示特征的和互动的16S rRNA模拟确定新的抗生素

    公开(公告)号：EP0804454B1

    公开(公告)日：2004-05-26

    申请号：EP95930926.1

    申请日：1995-08-23

    申请人： UNIVERSITY OF MASSACHUSETTS MEDICAL CENTER

    发明人： STERN, Seth ,  PUROHIT, Prakash

    IPC分类号： C07H21/02 ,  C12Q1/68

    CPC分类号： C12Q1/689 ,  C12Q1/6811 ,  C12Q1/6888

    摘要： The oligoribonucleotide analogs of the invention, as exemplified in the figure, are relatively small, three-dimensional structures derived from larger parental RNA molecules. The analogs include a first nucleic acid structure including one or more nucleotide sequences that are derived from a region of parental RNA, wherein in its native state, the region binds to a ligand, e.g., an aminoglycoside, with a parental RNA ligand binding pattern, and a second nucleic acid structure including one or more nucleotide sequences combined with the first nucleic acid structure to form the analog and provide the analog with a conformation that binds the ligand with a ligand binding pattern that is substantially identical to the parental RNA ligand binding pattern. These analogs can be used to identify novel therapeutic compounds.

    HYBRIDIZATION AND FOOTPRINTING METHODS TO CHARACTERIZE THE INTERACTIONS OF 16S rRNA ANALOGUES FOR IDENTIFICATION OF NOVEL ANTIBIOTICS
    2.
    发明公开
    HYBRIDIZATION AND FOOTPRINTING METHODS TO CHARACTERIZE THE INTERACTIONS OF 16S rRNA ANALOGUES FOR IDENTIFICATION OF NOVEL ANTIBIOTICS 失效
    杂交和施加过程表示特征的和互动的16S rRNA模拟确定新的抗生素

    公开(公告)号：EP0804454A1

    公开(公告)日：1997-11-05

    申请号：EP95930926.0

    申请日：1995-08-23

    申请人： UNIVERSITY OF MASSACHUSETTS MEDICAL CENTER

    发明人： STERN, Seth ,  PUROHIT, Prakash

    IPC分类号： C12Q1

    CPC分类号： C12Q1/689 ,  C12Q1/6811 ,  C12Q1/6888

    摘要： The oligoribonucleotide analogs of the invention, as exemplified in the figure, are relatively small, three-dimensional structures derived from larger parental RNA molecules. The analogs include a first nucleic acid structure including one or more nucleotide sequences that are derived from a region of parental RNA, wherein in its native state, the region binds to a ligand, e.g., an aminoglycoside, with a parental RNA ligand binding pattern, and a second nucleic acid structure including one or more nucleotide sequences combined with the first nucleic acid structure to form the analog and provide the analog with a conformation that binds the ligand with a ligand binding pattern that is substantially identical to the parental RNA ligand binding pattern. These analogs can be used to identify novel therapeutic compounds.