公开(公告)号：EP2758038A4

公开(公告)日：2015-11-04

申请号：EP12834398

申请日：2012-09-24

申请人： US HEALTH

发明人： NABEL GARY J M D ,  KANEKIYO MASARO ,  WEI CHIH-JEN ,  MCTAMNEY PATRICK M ,  YASSINE HADI M ,  BOYINGTON JEFFREY C

IPC分类号： A61K9/14 ,  A61K39/145

CPC分类号： A61K39/145 ,  A61K39/105 ,  A61K39/12 ,  A61K2039/55555 ,  A61K2039/55566 ,  A61K2039/575 ,  A61K2039/6031 ,  A61K2039/70 ,  C07K14/005 ,  C07K14/205 ,  C07K2319/00 ,  C07K2319/21 ,  C07K2319/35 ,  C07K2319/40 ,  C07K2319/735 ,  C12N7/00 ,  C12N2760/16022 ,  C12N2760/16034 ,  C12N2760/16071 ,  C12N2760/16134 ,  C12N2760/16234 ,  G01N33/56983

摘要： Novel vaccines are provided that elicit broadly neutralizing anti-influenza antibodies. Some vaccines comprise nanoparticles that display hemagglutinin trimers from influenza virus on their surface. The nanoparticles comprise fusion proteins comprising a monomeric subunit of ferritin joined to at least a portion of an influenza hemagglutinin protein. Some portions comprise the ectodomain while some portions are limited to the stem region. The fusion proteins self-assemble to form the hemagglutinin-displaying nanoparticles. Some vaccines comprise only the stem region of an influenza hemagglutinin protein joined to a trimerization domain. Such vaccines can be used to vaccinate an individual against infection by heterologous influenza viruses and influenza virus that are antigenically divergent from the virus from which the nanoparticle hemagglutinin protein was obtained. Also provided are fusion proteins and nucleic acid molecules encoding such proteins.

摘要翻译： 提供了引发广泛中和的抗流感抗体的新型疫苗。 一些疫苗包括在其表面上显示流感病毒的血凝素三聚体的纳米颗粒。 纳米颗粒包含融合蛋白，其包含与至少一部分流感血凝素蛋白结合的铁蛋白单体亚单位。 一些部分包含胞外域，而一些部分被限制在茎区。 融合蛋白自组装形成血凝素显示纳米粒子。 一些疫苗仅包含连接到三聚域的流感血凝素蛋白的茎区。 这样的疫苗可以用于接种个体，以抵抗来自获得纳米颗粒血凝素蛋白质的病毒的抗原性分歧的异源流感病毒和流感病毒的感染。 还提供了编码这种蛋白质的融合蛋白和核酸分子。