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公开(公告)号：EP4429669A1
公开(公告)日：2024-09-18
申请号：EP22817598.0
申请日：2022-11-10
申请人： Umecrine AB
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2.发明授权GABA-STEROID ANTAGONISTS AND THEIR USE FOR THE TREATMENT OF CNS DISORDERS 有权GABA类固醇拮抗剂和它们用于中枢神经系统疾病的治疗
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公开(公告)号：EP1458399A1
公开(公告)日：2004-09-22
申请号：EP02793723.4
申请日：2002-12-20
申请人： Umecrine AB
CPC分类号： A61K31/573 , A61K31/56 , A61K31/57
摘要： Steroid compounds prossessing a hydrogen donor in 3beta position, either in the form of a hydroxy- or a sulfate group, function as efficient blockers of the 3alpha-hydroxy-pregnan-steroid action and thus have utility as therapeutic substances for the prevention and/or treatment of steroid related CNS disorders. Treatment methods based on the administration of these substances are disclosed, and these substances either alone or in combination are also suggested for the manufacture of pharmaceuticals for the treatment of many specific steroid induced CNS disorders.
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公开(公告)号：EP4430057A1
公开(公告)日：2024-09-18
申请号：EP22817596.4
申请日：2022-11-10
申请人： Umecrine AB
CPC分类号： C07J41/0016 , C07J1/0011 , A61P3/04 , A61P3/10 , A61P15/00 , A61P25/30 , A61P25/32
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5.发明公开
公开(公告)号：EP4430056A1
公开(公告)日：2024-09-18
申请号：EP22817597.2
申请日：2022-11-10
申请人： Umecrine AB
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公开(公告)号：EP1458399B1
公开(公告)日：2012-08-08
申请号：EP02793723.4
申请日：2002-12-20
申请人： Umecrine AB
IPC分类号： A61K31/573
CPC分类号： A61K31/573 , A61K31/56 , A61K31/57
摘要： Steroid compounds prossessing a hydrogen donor in 3beta position, either in the form of a hydroxy- or a sulfate group, function as efficient blockers of the 3alpha-hydroxy-pregnan-steroid action and thus have utility as therapeutic substances for the prevention and/or treatment of steroid related CNS disorders. Treatment methods based on the administration of these substances are disclosed, and these substances either alone or in combination are also suggested for the manufacture of pharmaceuticals for the treatment of many specific steroid induced CNS disorders.
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7.发明公开THE USE OF PREGNANE AND ANDROSTANE STEROIDS FOR THE MANUFACTURE OF A PHARMACEUTICAL COMPOSITION FOR THE TREATMENT OF CNS DISORDERS 有权使用和生产的药物组合物的中枢神经系统疾病治疗孕ANDROSTANSTEROIDEN
公开(公告)号：EP2097437A1
公开(公告)日：2009-09-09
申请号：EP07835459.4
申请日：2007-11-20
申请人： Umecrine AB
IPC分类号： C07J7/00 , A61K31/568 , A61K31/5685 , A61K31/57 , A61P25/00 , A61P25/10 , A61P25/28 , C07J1/00 , C07J41/00
CPC分类号： C07J7/009 , C07J1/00 , C07J1/0011 , C07J5/0015 , C07J7/00 , C07J7/002 , C07J7/0065 , C07J7/007 , C07J41/00 , C07J41/0016 , C07J41/005
摘要： Steroid compounds having increased resistance against metabolism and increased water solubilit y are disclosed, together with methods for their production. These substances are suitable for the manufacture of pharmaceuticals for the treatment of steroid related or steroid induced CNS disorders and for use in methods of prevention, alleviation or treatment of such disorders.
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8.发明公开GABA-STEROID ANTAGONISTS AND THEIR USE FOR THE TREATMENT OF CNS DISORDERS 有权GABA类固醇拮抗剂和它们用于中枢神经系统疾病的治疗
公开(公告)号：EP1812009A1
公开(公告)日：2007-08-01
申请号：EP05801885.4
申请日：2005-11-07
申请人： Umecrine AB
摘要： Compounds exhibiting 3alpha-hydroxy-5alpha/beta-steroid blocking action with no or only low antagonism against the gamma-aminobutyric acid (A) receptor (GABA-A), and compounds exhibiting partial antagonism against said receptor are presented. Methods for the prevention, treatment and/or alleviation of various CNS-disorders are suggested, as well as pharmaceutical compositions for such use.
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