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    EMBRYO QUALITY ASSESSMENT BASED ON BLASTOMERE CLEAVAGE AND MORPHOLOGY
    2.
    发明公开
    EMBRYO QUALITY ASSESSMENT BASED ON BLASTOMERE CLEAVAGE AND MORPHOLOGY 有权
    EMBRYONENQUALITÄTSBEURTEILUNGAUF DER BASIS VON BLASTOMERSPALTUNG UND MORPHOLOGIE

    公开(公告)号：EP2714895A1

    公开(公告)日：2014-04-09

    申请号：EP12728169.9

    申请日：2012-05-31

    申请人： Unisense FertiliTech A/S

    发明人： RAMSING, Niels B ,  HILLIGSØE, Karen Marie ,  ESCRIVÁ, Marcos Meseguer

    IPC分类号： C12N5/073 ,  G06K9/00 ,  G01N3/50

    CPC分类号： G01N33/5005 ,  G06K9/0014 ,  G06T7/0016 ,  G06T2207/10016 ,  G06T2207/10056 ,  G06T2207/20224 ,  G06T2207/30044

    摘要： The present invention relates to a method and to a system for selecting embryos for in vitro fertilization based on the timing, and duration of observed cell cleavages and associated cell morphology. One embodiment of the invention relates to a method for determining embryo quality comprising monitoring the embryo for a time period, and determining one or more quality criteria for said embryo, wherein said one or more quality criteria is based on the extent of irregularity of the timing of cell divisions when the embryo develops from four to eight blastomeres, and/or wherein said one or more quality criteria is based on determining the time of cleavage to a five blastomere embryo (t5) and wherein t5 is between 48.7 hours and 55.6 hours, and/or wherein said one or more quality criteria is based on the ratio of two time intervals, each of said two time intervals determined as the duration of a time period between two morphological events in the embryo development from fertilization to eight blastomeres, and based on said one or more quality criteria determining the embryo quality.

    摘要翻译： 本发明涉及一种基于观察到的细胞切割和相关细胞形态的时间和持续时间来选择体外受精胚胎的方法和系统。 本发明的一个实施例涉及一种用于确定胚胎质量的方法，包括在一段时间内监测胚胎，以及确定所述胚胎的一个或多个质量标准，其中所述一个或多个质量标准基于所述时间的不规则程度 当胚胎从四个卵裂球发展到八个卵裂球时，和/或其中所述一个或多个质量标准基于确定切割到五个卵裂球胚胎的时间（t5），并且其中t5在48.7小时至55.6小时之间， 和/或其中所述一个或多个质量标准基于两个时间间隔的比率，所述两个时间间隔中的每一个被确定为从受精到八个卵裂球的胚胎发育中的两个形态事件之间的时间段的持续时间，并且基于 关于确定胚胎质量的一个或多个质量标准。

    EMBRYO INCUBATOR INCORPORATING GAS CONTROL
    3.
    发明公开
    EMBRYO INCUBATOR INCORPORATING GAS CONTROL 审中-公开
    胚胎孵化MIT GASREGELUNG

    公开(公告)号：EP2906680A1

    公开(公告)日：2015-08-19

    申请号：EP13776801.6

    申请日：2013-10-14

    申请人： Unisense FertiliTech A/S

    发明人： PEDERSEN, Thomas William ,  PLOUGSGAARD, Holger Søe ,  RAMSING, Niels B

    IPC分类号： C12M3/00 ,  C12M1/00 ,  C12M1/34

    CPC分类号： C12M21/06 ,  C12M41/14 ,  C12M41/34

    摘要： The invention relates to an incubator having a chamber for cultivating embryos and a gas control system for maintaining a constant atmosphere in the incubating chamber. In a first aspect the invention relates to an incubator for incubating embryos, comprising an incubating chamber adapted to contain the embryos, and a gas unitary module in fluid communication with the incubating chamber comprising at least two proportional valves, a CO
    2 gas sensor and an O
    2 gas sensor, wherein the gas unitary module is adapted to receive a gas supply of N
    2 at one of said proportional valves and CO
    2 at another of said proportional valves, and control the proportional valves based on feedback from the gas sensors such that supply of N
    2 and CO
    2 to the incubation chamber is regulated to sustain a predefined level of O
    2 and/or CO
    2 in said incubating chamber.

    EMBRYO QUALITY ASSESSMENT BASED ON BLASTOCYST DEVELOPMENT
    4.
    发明公开
    EMBRYO QUALITY ASSESSMENT BASED ON BLASTOCYST DEVELOPMENT 有权
    EMBRYO-QUALITÄTSBEURTEILUNGBASIEREND AUF DER BLASTOZYSTENENTWICKLUNG

    公开(公告)号：EP2855664A1

    公开(公告)日：2015-04-08

    申请号：EP13729621.6

    申请日：2013-05-31

    申请人： Unisense FertiliTech A/S

    发明人： RAMSING, Niels B ,  KRISTENSEN, Morten ,  LÆGDSMAND, Mette ,  KUHLMAN, Reidun Berghold ,  AGERHOLM, Inge Errebo ,  ISAKSEN, Mai Faurschou ,  GUNDERSEN, Jens K

    IPC分类号： C12N5/073 ,  G06K9/00

    CPC分类号： G01N33/5091 ,  C12N5/0604 ,  G06K9/00147 ,  G06K9/6282

    摘要： The present invention relates to a method and to a system for selecting embryos for in vitro fertilization based on observed cell kinetics and cell morphology. One embodiment of the invention relates to a method for determining embryo quality comprising monitoring the embryo for a time period, said time period comprising the transformation of the embryo from initial compaction or morula to blastocyst and determining one or more blastocyst quality criteria for said embryo, and based on said one or more blastocyst quality criteria determining the embryo quality.

    摘要翻译： 本发明涉及一种基于观察到的细胞动力学和细胞形态来选择体外受精胚胎的方法和系统。 本发明的一个实施方案涉及一种用于确定胚胎质量的方法，包括在一段时间内监测胚胎，所述时间段包括将胚胎从初始压实或桑ula转化为胚泡并确定所述胚胎的一个或多个胚泡质量标准， 并且基于所述一种或多种确定胚胎质量的胚泡质量标准。