公开(公告)号：EP2003197A2

公开(公告)日：2008-12-17

申请号：EP06841754.2

申请日：2006-12-22

申请人： Universidad Autónoma de Madrid

发明人： IZQUIERDO ROJO, Marta ,  GARCIA-ESCUDERO BARRERAS, Vega ,  GARGINI, Ricardo

IPC分类号： C12N9/24 ,  C12N9/04 ,  A61K38/47 ,  A61K38/44

CPC分类号： A61K38/45 ,  A61K38/443

摘要： The invention relates to a system capable of causing the death of tumor cells by activating caspase-independent apoptosis, comprising:
I. a cyanogenic system comprising the enzymatic activity exerted by linamarase on linamarin and an oxidative stress inducing system comprising the oxidative activity by the glucose oxidase enzyme combined in a single composition or
II. a cyanogenic system comprising the enzymatic activity exerted by linamarase on linamarin and an oxidative stress inducing system comprising the oxidative activity exerted by the glucose oxidase enzyme present in independent compositions.

摘要翻译： 本发明涉及一个系统，它能够通过激活胱天蛋白酶非依赖性细胞凋亡，包括使肿瘤细胞死亡的：I.一氰生成系统包含通过亚麻苦苷酶对琳娜·马林发挥的酶活性，并氧化应激诱导系统由葡萄糖包含的氧化活性 氧化酶组合在单个组合物或II。一个氰生成系统包含通过上琳娜·马林亚麻苦苷酶发挥的酶活性和氧化应激诱导系统，其包括由存在于组合物独立葡萄糖氧化酶所发挥的氧化活性。