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1.发明授权USE OF MAS-G-PROTEIN-COUPLED RECEPTOR AGONISTS IN THE TREATMENT OF THE METABOLIC SYNDROME, ITS COMPONENTS AND ITS COMPLICATIONS 有权MAS的G蛋白偶联受体的激动剂的代谢综合征，及其组成和并发症的治疗用途
公开(公告)号：EP2018185B1
公开(公告)日：2016-08-31
申请号：EP07719268.0
申请日：2007-04-26
发明人： SOUZA DOS SANTOS, Robson Augusto , SOUSA SANTOS, Sergio Henrique , ALVAREZ LEITE, Jaqueline Isaura , MATOS DE MOURA, Marina , SIQUEIRA HAIBARA, Andrea , RODRIQUES FERNANDEZ, Luciana , BADER, Michael , ALENINA, Natalia , SINISTERRA, Rubens Dario
IPC分类号： A61K45/00 , A61K38/08 , A61K31/415 , A61P3/00 , G01N33/50
CPC分类号： A61K31/415 , A61K38/085 , G01N33/68 , G01N33/6893 , G01N2333/726 , G01N2500/00
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2.发明公开USE OF MAS-G-PROTEIN-COUPLED RECEPTOR AGONISTS IN THE TREATMENT OF THE METABOLIC SYNDROME, ITS COMPONENTS AND ITS COMPLICATIONS 有权MAS的G蛋白偶联受体的激动剂的代谢综合征，及其组成和并发症的治疗用途
公开(公告)号：EP2018185A1
公开(公告)日：2009-01-28
申请号：EP07719268.0
申请日：2007-04-26
发明人： SOUZA DOS SANTOS, Robson Augusto , SOUSA SANTOS, Sergio Henrique , ALVAREZ LEITE, Jaqueline Isaura , MATOS DE MOURA, Marina , SIQUEIRA HAIBARA, Andrea , RODRIQUES FERNANDEZ, Luciana , BADER, Michael , ALENINA, Natalia , SINISTERRA, Rubens Dario
IPC分类号： A61K45/00 , A61K38/08 , A61K31/415 , A61P3/00 , G01N33/50
CPC分类号： A61K31/415 , A61K38/085 , G01N33/68 , G01N33/6893 , G01N2333/726 , G01N2500/00
摘要： The present invention is characterized by the use of Mas-G- protein-coupled receptor agonists for the control, prevention and treatment of the body levels of triglycerides, cholesterol and glucose, as well as of hyper- tension and possible increase in body weight, which are characteristic of the clinical manifestation of the metabolic syndrome and its complications. Another characteristic of the invention is the use of Mas-G-protein- coupled receptor agonists, including the Angiotensin-(1-7) peptide and its analogs, agonists, either peptidic or non-peptidic, as modulators of the mani- festations of insulin resistance and glucose intolerance and in the prevention and treatment of the related alterations. The invention claims the use of MAS-G-protein-coupled receptor agonists, formulated with pharmaceutically and pharmacologically acceptable excipients or carriers, and Mas-G-protein-coupled receptor agonists, includ- ing the Angiotensin-(1-7) peptide and its analogs, agonists, either peptidic or non-peptidic, as modulators of the metabolic syndrome, the diseases that compose it and its complications.
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