公开(公告)号：EP1904087A2

公开(公告)日：2008-04-02

申请号：EP06741348.4

申请日：2006-06-28

申请人： Universidade Federal de Minas Gerais

发明人： SOUZA DOS SANTOS, Robson Augusto ,  VELOSO BRANT PINHEIRO, Sérgio ,  DE FARIA E SILVA, Raphael ,  SILVA LULA, Ivana ,  BARROS DE SOUSA, Frederico ,  FRÉZARD, Frédéric Jean Georges ,  DOS REIS, Adelina Martha ,  DE FRANCA, Luiz Renato ,  FERREIRA, Anderson, José ,  SINISTERRA, Rubén Dario ,  CAMPAGNOLE-SANTOS, Maria José ,  DE OLIVEIRA SAMPAIO, Walkyria Neyde ,  DE CASTRO LEAL, Marcelo ,  KAPPES BECKER, Lenice

IPC分类号： A61K38/08 ,  A61P43/00

CPC分类号： A61K38/085

摘要： The present invention is characterized by the use of Mas G- protein-coupled receptor agonists and antagonists as apoptotic activity modulators for study, prevention and treatment of diseases. It is further characterized by the use of Mas G-protein-coupled receptor agonist and antagonists for modulation of the apoptotic activity involving alterations in the activity of the protein kinase B/Akt. Another characteristic of the invention is the use of Mas G-protein-coupled receptor agonists and antagonists, including the Ang- (1-7) peptide and its analogues, agonists and antagonists, either peptidic or non-peptidic, as modulators of apoptotic activity for study, prevention and treatment of degenerative diseases of organs and systems, as an auxiliary measure for organs transplantation, treatment with embryonic, non- embryonic stem cells, re-implantation of organs and tissues and other treatments that need temporary or chronic reduction of the apoptotic activity, not limitative. The invention further claims the use of Mas G-protein-coupled receptor agonists and antagonists, including the Angiotensin-(1-7) peptide and its analogues, agonists and antagonists, either peptidic or non-peptidic, formulated with pharmaceutically and pharmacologically acceptable excipients or carriers, as modulators of the apoptotic activity.