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公开(公告)号：EP3434686A1
公开(公告)日：2019-01-30
申请号：EP16894820.6
申请日：2016-05-10
发明人： BARUFFI, Marcelo Dias , ANDRADE, Camillo del Cistia , SILVA, Rubens Eduardo da , OLIVEIRA, Robinson Antonio Martins de , CALLEJON, Daniel Roberto
摘要： The present invention relates to a method for producing hybrid or non-hybrid recombinant glycoprotein hormones, for example the recombinant equine chorionic gonadotropin (r-eCG), the hybrid recombinant chorionic gonadotropin, the recombinant thyroid-stimulating hormone (r-TSH), the recombinant luteinising hormone (r-LH), the luteinising hormone and the recombinant follicle-stimulating hormone (r-FSH). In addition, the present invention relates to the recombinant glycoprotein hormones comprising the equine α and β subunits, inter alia, the α subunit of mammals and equine β subunit, where the two subunits are fused in a simple chain, and chain-modifying agents, which hormones are easier to purify, more homogeneous, easier to produce on an industrial scale without using animals, in comparison with the wild glycoprotein hormone. Moreover, the present invention relates to the use of these hormones in assisted animal reproduction, ovulation induction, superovulation induction, follicle growth, oestrus induction, anoestrus reversal, puberty induction in animals, both with and without commercial interest.
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公开(公告)号：EP2654897B1
公开(公告)日：2019-08-21
申请号：EP11805370.1
申请日：2011-12-09
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3.发明公开METHOD FOR INCREASING EMBRYO IMPLANTATION RATE IN MOTHER'S UTERUS IN MAMMALS, USE OF AN EFFECTIVE AMOUNT OF BETA - GALACTOSIDE - BINDING LECTIN OR DERIVATIVES THEREOF, BETA - GALACTOSIDE - BINDING LECTIN OR DERIVATIVES AND PRODUCT. 审中-公开法用于提高胚胎植入率在哺乳动物的子宫内使用活性β-半乳糖苷 - 结合凝集素或其衍生物，BETA半乳糖苷结合凝集素或其衍生物和产品
公开(公告)号：EP2654897A1
公开(公告)日：2013-10-30
申请号：EP11805370.1
申请日：2011-12-09
发明人： DIAS BARUFFI, Marcelo , DA SILVA CARVALHO MORANI, Erika , RONCOLETTA, Marcelo , ANDRADE, Camillo del Cistia , CATALDI RODRIGUES, Lílian
CPC分类号： C07K14/7056 , A61K38/1732 , A61K38/178 , C07K14/4726
摘要： The present invention relates to a method for increasing embryo implantation rate in mother's uterus in mammals by administering to the uterus of a mammal an effective amount of beta-galactoside-binding lectin or derivatives thereof, as well as to a product comprising said lectin.
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公开(公告)号：EP3623008A1
公开(公告)日：2020-03-18
申请号：EP19189687.7
申请日：2011-12-09
发明人： DIAS BARUFFI, Marcelo , DA SILVA CARVALHO MORANI, Erika , RONCOLETTA, Marcelo , ANDRADE, Camillo del Cistia , CATALDI RODRIGUES, Lilian
摘要： The present invention relates to a method for increasing embryo implantation rate in mother's uterus in mammals by administering to the uterus of a mammal an effective amount of beta-galactoside-binding lectin or derivatives thereof, as well as to a product comprising said lectin.
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