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1.发明授权SIGMA-2 RECEPTOR, METHOD OF SCREENING OF SPECIFIC LIGANDS AND USE OF THE SAME IN DIAGNOSTIC OR THERAPEUTIC METHODS 有权SIGMA-2受体，方法用于筛选用于诊断或治疗程序的特异性配体及其用途
公开(公告)号：EP1984734B8
公开(公告)日：2014-08-27
申请号：EP07700542.9
申请日：2007-01-05
IPC分类号： C07D295/096 , A61K31/495 , G01N33/50 , G01N33/574 , G01N33/68
CPC分类号： G01N33/5023 , A61K31/495 , C07D295/096 , G01N33/57496 , G01N33/6875
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2.发明公开NOVEL TETRAHYDROISOQUINOLINE COMPOUNDS FOR USE IN THE DIAGNOSIS AND TREATMENT OF NEURODEGENERATIVE DISEASES 有权新型四氢FOR USE在神经退行性疾病的诊断与治疗
公开(公告)号：EP2714682A1
公开(公告)日：2014-04-09
申请号：EP11722049.1
申请日：2011-05-24
发明人： COLABUFO, Nicola Antonio , BERARDI, Francesco , CANTORE, Mariangela , CONTINO, Marialessandra , LEOPOLDO, Marcello , PERRONE, Roberto
IPC分类号： C07D413/04 , C07D417/04 , A61K31/42 , A61K31/426
CPC分类号： A61K51/0455 , C07B59/002 , C07D413/04 , C07D413/06 , C07D417/04 , C07D417/06
摘要： The invention relates to a new class of compounds with high affinity and selectivity towards P-glycoprotein. The invention also relates to the utilization of such compounds in the in vivo diagnosis of neurodegenerative diseases and as medicaments for use in the prevention and treatment of neurodegenerative disease involving P-glycoprotein.
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3.发明授权NOVEL TETRAHYDROISOQUINOLINE COMPOUNDS FOR USE IN THE DIAGNOSIS AND TREATMENT OF NEURODEGENERATIVE DISEASES 有权新型四氢FOR USE在神经退行性疾病的诊断与治疗
公开(公告)号：EP2714682B1
公开(公告)日：2016-03-16
申请号：EP11722049.1
申请日：2011-05-24
发明人： COLABUFO, Nicola Antonio , BERARDI, Francesco , CANTORE, Mariangela , CONTINO, Marialessandra , LEOPOLDO, Marcello , PERRONE, Roberto
IPC分类号： C07D413/04 , C07D417/04 , A61K31/42 , A61K31/426
CPC分类号： A61K51/0455 , C07B59/002 , C07D413/04 , C07D413/06 , C07D417/04 , C07D417/06
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