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1.发明公开NOVEL TETRAHYDROISOQUINOLINE COMPOUNDS FOR USE IN THE DIAGNOSIS AND TREATMENT OF NEURODEGENERATIVE DISEASES 有权新型四氢FOR USE在神经退行性疾病的诊断与治疗
公开(公告)号：EP2714682A1
公开(公告)日：2014-04-09
申请号：EP11722049.1
申请日：2011-05-24
发明人： COLABUFO, Nicola Antonio , BERARDI, Francesco , CANTORE, Mariangela , CONTINO, Marialessandra , LEOPOLDO, Marcello , PERRONE, Roberto
IPC分类号： C07D413/04 , C07D417/04 , A61K31/42 , A61K31/426
CPC分类号： A61K51/0455 , C07B59/002 , C07D413/04 , C07D413/06 , C07D417/04 , C07D417/06
摘要： The invention relates to a new class of compounds with high affinity and selectivity towards P-glycoprotein. The invention also relates to the utilization of such compounds in the in vivo diagnosis of neurodegenerative diseases and as medicaments for use in the prevention and treatment of neurodegenerative disease involving P-glycoprotein.
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2.发明公开
公开(公告)号：EP4301739A1
公开(公告)日：2024-01-10
申请号：EP22714240.3
申请日：2022-03-02
发明人： LEOPOLDO, Marcello , LACIVITA, Enza , MASTROMARINO, Margherita , PERRONE CAPANO, Carla , VOLPICELLI, Floriana , CRISPINO, Marianna , CRISTIANO, Claudia , CALIGNANO, Antonio
IPC分类号： C07D295/185 , C07D211/38 , C07D223/12 , C07D209/44 , C07D209/08 , C07D471/04 , C07D217/06 , C07D215/08 , A61K31/40 , A61K31/4015 , A61K31/4035 , A61K31/404 , A61K31/445 , A61K31/4465 , A61K31/47 , A61K31/472 , A61P25/00
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3.发明授权NOVEL TETRAHYDROISOQUINOLINE COMPOUNDS FOR USE IN THE DIAGNOSIS AND TREATMENT OF NEURODEGENERATIVE DISEASES 有权新型四氢FOR USE在神经退行性疾病的诊断与治疗
公开(公告)号：EP2714682B1
公开(公告)日：2016-03-16
申请号：EP11722049.1
申请日：2011-05-24
发明人： COLABUFO, Nicola Antonio , BERARDI, Francesco , CANTORE, Mariangela , CONTINO, Marialessandra , LEOPOLDO, Marcello , PERRONE, Roberto
IPC分类号： C07D413/04 , C07D417/04 , A61K31/42 , A61K31/426
CPC分类号： A61K51/0455 , C07B59/002 , C07D413/04 , C07D413/06 , C07D417/04 , C07D417/06
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4.发明公开
公开(公告)号：EP2714665A1
公开(公告)日：2014-04-09
申请号：EP11721044.3
申请日：2011-05-24
发明人： LEOPOLDO, Marcello , LACIVITA, Enza , COLABUFO, Nicola, Antonio , DE GIORGIO, Paola , BERARDI, Francesco , PERRONE, Roberto
IPC分类号： C07D239/26 , C07D241/12 , C07D401/04 , C07D295/084 , A61K31/506 , A61P25/06
CPC分类号： C07D295/096 , A61K51/0459 , C07D239/26 , C07D241/12 , C07D295/084 , C07D401/04 , C07D401/14 , C07D403/04
摘要： The invention relates to a new class of compounds able to inhibit with high affinity and selectivity the 5-HT7 receptor. The invention also relates to the utilization of such compounds as medicaments useful in the treatment and prevention of 5-HT7 receptor relating disorders of the central nervous system. The invention also relates to the isotopically labeled compounds for use in vivo diagnosis or imaging of a 5-HT7 condition.
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