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1.发明公开New 1-arylpiperazinic ligands of 5-HT7 receptor and use thereof 审中-公开Neue 1-Arylpiperazin-Liganden vom 5-HT7-Rezeptor und Verwendung davon
公开(公告)号：EP2816037A2
公开(公告)日：2014-12-24
申请号：EP14179594.8
申请日：2011-05-24
发明人： Leopoldo, Marcello , Lacivita, Enza , Colabufo, Nicola Antonio , De Giorgio, Paola , Berardi, Francesco , Perrone, Roberto
IPC分类号： C07D239/26 , C07D241/12 , C07D401/04 , C07D295/084 , A61K31/506 , A61P25/06
CPC分类号： C07D295/096 , A61K51/0459 , C07D239/26 , C07D241/12 , C07D295/084 , C07D401/04 , C07D401/14 , C07D403/04
摘要： The invention relates to a new class of compounds able to inhibit with high affinity and selectivity the 5-HT7 receptor. The invention also relates to the utilization of such compounds as medicaments useful in the treatment and prevention of 5-HT7 receptor relating disorders of the central nervous system. The invention also relates to the isotopically labeled compounds for use in vivo diagnosis or imaging of a 5-HT7 condition.
摘要翻译： 本发明涉及能够以高亲和力和选择性抑制5-HT7受体的新类化合物。 本发明还涉及这样的化合物作为可用于治疗和预防5-HT7受体相关疾病的中枢神经系统的药物的用途。 本发明还涉及用于5-HT7状态的体内诊断或成像的同位素标记的化合物。
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2.发明公开
公开(公告)号：EP2816037A3
公开(公告)日：2015-04-01
申请号：EP14179594.8
申请日：2011-05-24
发明人： Leopoldo, Marcello , Lacivita, Enza , Colabufo, Nicola Antonio , De Giorgio, Paola , Berardi, Francesco , Perrone, Roberto
IPC分类号： C07D239/26 , C07D241/12 , C07D401/04 , C07D295/084 , A61K31/506 , A61P25/06
CPC分类号： C07D295/096 , A61K51/0459 , C07D239/26 , C07D241/12 , C07D295/084 , C07D401/04 , C07D401/14 , C07D403/04
摘要： The invention relates to a new class of compounds able to inhibit with high affinity and selectivity the 5-HT7 receptor. The invention also relates to the utilization of such compounds as medicaments useful in the treatment and prevention of 5-HT7 receptor relating disorders of the central nervous system. The invention also relates to the isotopically labeled compounds for use in vivo diagnosis or imaging of a 5-HT7 condition.
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