公开(公告)号：EP3477305A1

公开(公告)日：2019-05-01

申请号：EP17198330.7

申请日：2017-10-25

申请人： Universität Heidelberg

发明人： Hildebrand, Dagmar ,  Heeg, Klaus ,  Uhle, Florian ,  Weigand, Markus A.

IPC分类号： G01N33/68

摘要： The invention refers to a method for in vitro diagnosis and/or prognosis of a severe infection comprising determining delta-like ligand 1 protein or a nucleotide sequence coding for delta-like ligand 1 protein in a biological sample wherein an elevated level of expression of delta-like ligand 1 protein or a nucleotide sequence coding for delta-like ligand 1 protein is indicative of a severe infection; and the use of delta-like ligand 1 protein as a biomarker for in vitro diagnosis and/or prognosis of a severe infection such as sepsis.

公开(公告)号：EP3438668A1

公开(公告)日：2019-02-06

申请号：EP17185036.5

申请日：2017-08-04

申请人： B.R.A.H.M.S GmbH ,  Universität Heidelberg

发明人： Brenner, Thorsten ,  Weigand, Markus Alexander ,  Uhle, Florian ,  Wilson, Darius Cameron

IPC分类号： G01N33/68 ,  G01N33/74

摘要： The invention relates to a method for the diagnosis and/or risk stratification of invasive fungal infections (IFI) / invasive fungal diseases (IFD) and in particular associated with sepsis or septic shock, wherein a determination of the marker proadrenomedullin (proADM) or a partial peptide or fragment thereof, in particular midregional proadrenomedullin (MR-proADM), or contained in a marker combination (panel, cluster), is carried out from a patient to be examined. Furthermore, the invention relates to a diagnostic assay and a kit for carrying out the method.