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公开(公告)号：EP4356920A3
公开(公告)日：2024-06-12
申请号：EP24150131.1
申请日：2020-10-02
申请人： Universität Zürich
IPC分类号： C12N5/0789 , A61K35/15 , A61K35/28 , C12N15/87 , A61K38/00 , C07K14/00 , A61K39/00 , C07K14/80 , C12N9/02 , C12N15/86 , A61K48/00
CPC分类号： C12N5/0647 , C12N2510/0020130101 , A61K35/28 , A61K38/00 , C12N15/86 , C12N2740/1604320130101 , A61K48/0058 , C07K14/80 , C12N9/0036 , C12Y106/03001 , A61K39/461 , A61K2239/3120230501 , A61K39/464
摘要： The present invention relates to an isolated human hematopoietic stem cell or progenitor cell, transduced with a lentiviral vector which comprises a coding nucleic acid sequence encoding a functional variant of a polypeptide selected from gp91phox, p22phox, p40phox, p47phox, p67phox and Rac2; under transcriptional control of a promoter sequence that comprises or essentially consists of the miR223 promoter sequence (SEQ ID NO 01).
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公开(公告)号：EP4356920A2
公开(公告)日：2024-04-24
申请号：EP24150131.1
申请日：2020-10-02
申请人： Universität Zürich
IPC分类号： A61K38/00
CPC分类号： C12N5/0647 , C12N2510/0020130101 , A61K35/28 , A61K38/00 , C12N15/86 , C12N2740/1604320130101 , A61K48/0058 , C07K14/80 , C12N9/0036 , C12Y106/03001
摘要： The present invention relates to an isolated human hematopoietic stem cell or progenitor cell, transduced with a lentiviral vector which comprises a coding nucleic acid sequence encoding a functional variant of a polypeptide selected from gp91phox, p22phox, p40phox, p47phox, p67phox and Rac2; under transcriptional control of a promoter sequence that comprises or essentially consists of the miR223 promoter sequence (SEQ ID NO 01).
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