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1.发明公开
公开(公告)号：EP4238610A1
公开(公告)日：2023-09-06
申请号：EP22159975.6
申请日：2022-03-03
申请人： Universität der Bundeswehr München , Technische Universität München , Ludwig-Maximilians-Universität München
发明人： Schauer, Jannis , Dollinger, Günther , Ruser, Heinrich , Huang, Yuanhui , Ntziachristos, Vasilis , Wieser, Hans Peter , Parodi, Katia
IPC分类号： A61N5/10
摘要： Disclosed herein is a method of determining information regarding the location of energy deposition of an ion beam (14) in an absorptive medium, comprising the following steps: generating a pulsed ion beam (16), detecting a time-resolved acoustic signal, said time-resolved acoustic signal comprising an energy-deposition-signal component attributable to the energy deposition of an individual pulse of said pulsed ion beam in said absorptive medium, determining relative timing information of the energy deposition of said individual pulse with respect to said time-resolved acoustic signal, providing a matched filter for processing the time-resolved acoustic signal, and applying said matched filter to said time-resolved acoustic signal, deriving, from the filtered time-resolved signal, occurrence timing information related to the occurrence of said energy-deposition signal component in said time-resolved acoustic signal, and deriving information regarding the location of the energy deposition based, at least in part, on a delay between said energy deposition of said individual pulse and said occurrence timing information.
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公开(公告)号：EP2974771B1
公开(公告)日：2016-11-02
申请号：EP14182487.0
申请日：2014-08-27
发明人： Dollinger, Günther , Parodi, Katia , Assmann, Walter , Ntziachristos, Vasilis , Kellnberger, Stephan
CPC分类号： A61N5/1049 , A61N5/1048 , A61N2005/1058 , A61N2005/1087 , A61N2005/1088 , A61N2005/1095
摘要： Disclosed is a method of determining information regarding the location of energy deposition of an ion beam, in particular a proton beam, in an absorptive medium, in particular in the tissue of a patient undergoing radiation therapy, comprising the following steps: - generating an intensity modulated ion beam, wherein the intensity modulation comprises one or more modulation frequency components, - detecting an acoustic signal attributable to the time dependent energy deposition in said absorptive medium by said intensity modulated ion beam using at least one detection apparatus, said detection apparatus being preferably configured for extracting at least one modulation frequency component of the acoustic signal corresponding to a respective one of the one or more modulation frequency components of said intensity modulation, or a harmonic thereof, and - deriving information regarding the location of the energy deposition based, at least in part, on a time lag between the timing of the intensity modulation of said ion beam and said acoustic signal.
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3.发明公开A method and apparatus for determining an energy deposition of an ion beam 有权Vorrichtung zur Bestimmung einer Energiedeponierung eines Ionenstrahls
公开(公告)号：EP2974771A1
公开(公告)日：2016-01-20
申请号：EP14182487.0
申请日：2014-08-27
发明人： Dollinger, Günther , Parodi, Katia , Assmann, Walter , Ntziachristos, Vasilis , Kellnberger, Stephan
CPC分类号： A61N5/1049 , A61N5/1048 , A61N2005/1058 , A61N2005/1087 , A61N2005/1088 , A61N2005/1095
摘要： Disclosed is a method of determining information regarding the location of energy deposition of an ion beam, in particular a proton beam, in an absorptive medium, in particular in the tissue of a patient undergoing radiation therapy, comprising the following steps:
- generating an intensity modulated ion beam, wherein the intensity modulation comprises one or more modulation frequency components,
- detecting an acoustic signal attributable to the time dependent energy deposition in said absorptive medium by said intensity modulated ion beam using at least one detection apparatus, said detection apparatus being preferably configured for extracting at least one modulation frequency component of the acoustic signal corresponding to a respective one of the one or more modulation frequency components of said intensity modulation, or a harmonic thereof, and
- deriving information regarding the location of the energy deposition based, at least in part, on a time lag between the timing of the intensity modulation of said ion beam and said acoustic signal.摘要翻译： 公开了一种确定关于在吸收介质中，特别是在经历放射治疗的患者的组织中的离子束，特别是质子束的能量沉积的位置的信息的方法，包括以下步骤： - 产生强度 调制离子束，其中所述强度调制包括一个或多个调制频率分量， - 使用至少一个检测装置，通过所述强度调制离子束检测归因于所述吸收介质中的时间依赖性能量沉积的声信号，所述检测装置优选地 被配置为提取对应于所述强度调制的一个或多个调制频率分量中的相应一个的声信号的至少一个调制频率分量或其谐波，以及 - 基于能量沉积的位置导出关于基于 至少部分地，在时间之间的时间差 所述离子束和所述声信号的强度调制。
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4.发明公开
公开(公告)号：EP3944725A1
公开(公告)日：2022-01-26
申请号：EP20187438.5
申请日：2020-07-23
摘要： Disclosed herein is a method of manufacturing a radio frequency cavity resonator, wherein said radio frequency cavity resonator comprises a tubular structure extending along a longitudinal axis, said tubular structure comprising a circumferential wall structure surrounding said longitudinal axis, one or more tubular elements and a first and a second support structure associated with each of said tubular elements, wherein said first and second support structures are provided on opposite sides of each tubular element and extend radially along a diameter of the tubular structure, wherein the method comprises producing the resonator by additive manufacturing in a manufacturing direction that is parallel to said diameter.
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