公开(公告)号：EP4238610A1

公开(公告)日：2023-09-06

申请号：EP22159975.6

申请日：2022-03-03

申请人： Universität der Bundeswehr München ,  Technische Universität München ,  Ludwig-Maximilians-Universität München

发明人： Schauer, Jannis ,  Dollinger, Günther ,  Ruser, Heinrich ,  Huang, Yuanhui ,  Ntziachristos, Vasilis ,  Wieser, Hans Peter ,  Parodi, Katia

IPC分类号： A61N5/10

摘要： Disclosed herein is a method of determining information regarding the location of energy deposition of an ion beam (14) in an absorptive medium, comprising the following steps: generating a pulsed ion beam (16), detecting a time-resolved acoustic signal, said time-resolved acoustic signal comprising an energy-deposition-signal component attributable to the energy deposition of an individual pulse of said pulsed ion beam in said absorptive medium, determining relative timing information of the energy deposition of said individual pulse with respect to said time-resolved acoustic signal, providing a matched filter for processing the time-resolved acoustic signal, and applying said matched filter to said time-resolved acoustic signal, deriving, from the filtered time-resolved signal, occurrence timing information related to the occurrence of said energy-deposition signal component in said time-resolved acoustic signal, and deriving information regarding the location of the energy deposition based, at least in part, on a delay between said energy deposition of said individual pulse and said occurrence timing information.

公开(公告)号：EP2974771B1

公开(公告)日：2016-11-02

申请号：EP14182487.0

申请日：2014-08-27

申请人： Universität der Bundeswehr München ,  Ludwig-Maximilians-Universität München

发明人： Dollinger, Günther ,  Parodi, Katia ,  Assmann, Walter ,  Ntziachristos, Vasilis ,  Kellnberger, Stephan

IPC分类号： A61N5/10 ,  G21K1/04

CPC分类号： A61N5/1049 ,  A61N5/1048 ,  A61N2005/1058 ,  A61N2005/1087 ,  A61N2005/1088 ,  A61N2005/1095

摘要： Disclosed is a method of determining information regarding the location of energy deposition of an ion beam, in particular a proton beam, in an absorptive medium, in particular in the tissue of a patient undergoing radiation therapy, comprising the following steps: - generating an intensity modulated ion beam, wherein the intensity modulation comprises one or more modulation frequency components, - detecting an acoustic signal attributable to the time dependent energy deposition in said absorptive medium by said intensity modulated ion beam using at least one detection apparatus, said detection apparatus being preferably configured for extracting at least one modulation frequency component of the acoustic signal corresponding to a respective one of the one or more modulation frequency components of said intensity modulation, or a harmonic thereof, and - deriving information regarding the location of the energy deposition based, at least in part, on a time lag between the timing of the intensity modulation of said ion beam and said acoustic signal.

公开(公告)号：EP2974771A1

公开(公告)日：2016-01-20

申请号：EP14182487.0

申请日：2014-08-27

申请人： Universität der Bundeswehr München ,  Ludwig-Maximilians-Universität München

发明人： Dollinger, Günther ,  Parodi, Katia ,  Assmann, Walter ,  Ntziachristos, Vasilis ,  Kellnberger, Stephan

IPC分类号： A61N5/10 ,  G21K1/04

CPC分类号： A61N5/1049 ,  A61N5/1048 ,  A61N2005/1058 ,  A61N2005/1087 ,  A61N2005/1088 ,  A61N2005/1095

摘要： Disclosed is a method of determining information regarding the location of energy deposition of an ion beam, in particular a proton beam, in an absorptive medium, in particular in the tissue of a patient undergoing radiation therapy, comprising the following steps:
- generating an intensity modulated ion beam, wherein the intensity modulation comprises one or more modulation frequency components,
- detecting an acoustic signal attributable to the time dependent energy deposition in said absorptive medium by said intensity modulated ion beam using at least one detection apparatus, said detection apparatus being preferably configured for extracting at least one modulation frequency component of the acoustic signal corresponding to a respective one of the one or more modulation frequency components of said intensity modulation, or a harmonic thereof, and
- deriving information regarding the location of the energy deposition based, at least in part, on a time lag between the timing of the intensity modulation of said ion beam and said acoustic signal.

摘要翻译： 公开了一种确定关于在吸收介质中，特别是在经历放射治疗的患者的组织中的离子束，特别是质子束的能量沉积的位置的信息的方法，包括以下步骤： - 产生强度 调制离子束，其中所述强度调制包括一个或多个调制频率分量， - 使用至少一个检测装置，通过所述强度调制离子束检测归因于所述吸收介质中的时间依赖性能量沉积的声信号，所述检测装置优选地 被配置为提取对应于所述强度调制的一个或多个调制频率分量中的相应一个的声信号的至少一个调制频率分量或其谐波，以及 - 基于能量沉积的位置导出关于基于 至少部分地，在时间之间的时间差 所述离子束和所述声信号的强度调制。