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公开(公告)号：EP2508171B1
公开(公告)日：2014-05-07
申请号：EP11159810.8
申请日：2011-03-25
IPC分类号： A61K41/00 , A61K47/48 , A61K33/26 , A61K31/122 , A61K9/14 , A61K9/51 , A61K47/02 , A61K49/18 , A61P35/00
CPC分类号： A61K31/122 , A61K9/5123 , A61K41/00 , A61K47/6923
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2.发明公开Pharmaceutical magnetic nano-particle composition 有权Pharmazutische Zusammensetzung mit magnetischen Nanopartikeln
公开(公告)号：EP2508171A1
公开(公告)日：2012-10-10
申请号：EP11159810.8
申请日：2011-03-25
CPC分类号： A61K31/122 , A61K9/5123 , A61K41/00 , A61K47/6923
摘要： The invention relates to a pharmaceutical composition comprising magnetic nano-particles for magnetic targeting of drugs and imaging agents. The invention further relates to the use of said pharmaceutical composition as a drug carrier, for use as an imaging agent, for use as a medicament and specifically for use in cancer treatment by magnetic drug targeting using an external magnetic field. The present invention also relates to a method for manufacturing said pharmaceutical composition and a method for guiding and accumulating said pharmaceutical composition to a target tissue contained in a subject.
摘要翻译： 本发明涉及一种药物组合物，其包含用于药物和成像剂的磁性靶向的磁性纳米颗粒。 本发明还涉及所述药物组合物作为药物载体用作显像剂，用作药物并且特别用于通过使用外部磁场靶向药物进行癌症治疗的用途的用途。 本发明还涉及制造所述药物组合物的方法以及将所述药物组合物引导和积聚到受试者所包含的靶组织中的方法。
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3.发明公开
公开(公告)号：EP4235168A1
公开(公告)日：2023-08-30
申请号：EP22159238.9
申请日：2022-02-28
发明人： Vogel, Patrick , Rückert, Martin , Lyer, Stefan , Tietze, Rainer , Alexiou, Christoph , Friedrich, Bernhard
IPC分类号： G01N27/74 , G01N33/543
摘要： A method for measuring a modified property of a sample comprising magnetic particles in suspension using time variable magnetic fields comprises the steps of: applying a time-varying magnetic excitation field, the excitation field having an excitation amplitude and an excitation frequency, and an offset magnetic field to the sample, such that the magnetic particles are driven into a non-linear magnetization response regime; recording a non-linear magnetization response of the sample for obtaining a signal metric indicative for a phase of a higher harmonic with respect to the excitation frequency in the non-linear magnetization response; and determining a measurement signal indicative of the modified property, the measurement signal being based on the signal metric obtained for the sample and the same signal metric obtained for a reference sample without the modified property, the reference sample also comprising the magnetic particles in suspension.
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