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    METHOD AND DEVICE FOR CONTROLLING A MAGNETIC RESONANCE IMAGING SYSTEM
    1.
    发明公开
    METHOD AND DEVICE FOR CONTROLLING A MAGNETIC RESONANCE IMAGING SYSTEM 审中-公开

    公开(公告)号：EP3901648A1

    公开(公告)日：2021-10-27

    申请号：EP20171345.0

    申请日：2020-04-24

    申请人： Siemens Healthcare GmbH ,  Universitätsklinikum Erlangen

    发明人： Gumbrecht, Rene ,  Herrler, Jürgen ,  Liebig, Patrick ,  Nagel, Armin

    IPC分类号： G01R33/54 ,  G01R33/561 ,  G01R33/565

    摘要： The invention describes a pulse-design unit (12) for creating pulse data (SD, SD', SD") for controlling a magnetic resonance system (1) comprising a data interface (21) designed for receiving an examination scheme (E) and a calculation module (20) designed for generating pulse data (SD) based on an examination scheme (E), wherein the pulse-design unit (12) comprises a data grid and/or parameter values created from map pairs (M, M') of a plurality of patients and is designed to select and/or calculate pulse data (SD) using the data grid and/or parameter values and a provided examination scheme (E). The invention further describes a method and a control device for controlling an MRI system and a related magnetic resonance imaging system.

    Tag-aided sense-antisense transcript detection
    4.
    发明公开
    Tag-aided sense-antisense transcript detection 审中-公开
    EtikettunterstützteDetektion von Sense-Antisense-Transkript

    公开(公告)号：EP3042962A1

    公开(公告)日：2016-07-13

    申请号：EP15150338.0

    申请日：2015-01-07

    申请人： UNIVERSITÄTSKLINIKUM ERLANGEN

    发明人： Strick, Reiner ,  Henke, Christine

    IPC分类号： C12Q1/68

    CPC分类号： C12Q1/6848 ,  C12Q2521/107 ,  C12Q2525/155 ,  C12Q2527/127 ,  C12Q2531/113

    摘要： The present invention relates to a method for determining the sense/antisense polarity of an RNA transcript of interest in a sample, the method comprising: (a) reverse transcribing an RNA transcript of interest present in the sample, wherein the reverse transcription reaction comprises: (i) a primer linked to an oligonucleotide tag , wherein the primer specifically binds to (1) the sense strand of the RNA transcript of interest; or (2) the antisense strand of the RNA transcript of interest; (ii) a reverse transcriptase lacking or having a reduced RNase H activity; and (iii) an inhibitor of DNA-dependent DNA synthesis; (b) removing the RNA strand from the RNA:cDNA hybrid strand produced in step (a); (c) amplifying the first strand cDNA obtained in step (b) with a forward primer that specifically binds to said first strand cDNA and a reverse primer, wherein the reverse primer comprises or consists of a nucleic acid sequence that corresponds to the nucleotide sequence of the oligonucleotide tag, or to a portion thereof; and (d) detecting the presence of an amplification product, wherein the presence of an amplification product obtained after reverse transcribing the RNA transcript of interest in a reaction comprising the primer of (a)(i)(1) indicates that the RNA transcript is a sense-strand RNA transcript and the presence of an amplification product obtained after reverse transcribing the RNA transcript of interest in a reaction comprising the primer of (a)(i)(2) indicates that the RNA transcript is an antisense-strand RNA transcript; and wherein the oligonucleotide tag employed in step (a)(1) has a nucleic acid sequence that is not endogenously present in the genome of the organism from which the sample has been obtained. The present invention further relates to an oligonucleotide comprising or consisting of the nucleic acid sequence shown in SEQ ID NO:1 as well as a kit comprising an oligonucleotide according to the invention and at least one of: (i) a reverse transcriptase lacking or having a reduced RNase H activity; (ii) an inhibitor of DNA-dependent DNA synthesis; (iii) RNase H; and (iv) means for amplification of cDNA.

    摘要翻译： 本发明涉及一种用于确定样品中感兴趣的RNA转录物的正义/反义极性的方法，所述方法包括：（a）逆转录样品中存在的感兴趣的RNA转录物，其中所述逆转录反应包括： （i）与寡核苷酸标签连接的引物，其中引物特异性结合（1）感兴趣的RNA转录物的有义链; 或（2）感兴趣的RNA转录物的反义链; （ii）缺乏或具有降低的RNA酶H活性的逆转录酶; 和（iii）DNA依赖性DNA合成抑制剂; （b）从步骤（a）中产生的RNA：cDNA杂交链中除去RNA链; （c）用特异性结合所述第一链cDNA的正向引物和反向引物扩增步骤（b）中获得的第一链cDNA，其中所述反向引物包含与SEQ ID NO：1的核苷酸序列相对应的核酸序列 寡核苷酸标签或其一部分; （d）检测扩增产物的存在，其中在包含（a）（i）（1）的引物的反应中逆转录感兴趣的RNA转录物后获得的扩增产物的存在表明RNA转录物是 有义链RNA转录物和在包含（a）（i）（2）的引物的反应中逆转录感兴趣的RNA转录物后获得的扩增产物的存在表明RNA转录物是反义链RNA转录物 ; 并且其中步骤（a）（1）中使用的寡核苷酸标签具有不是内源性存在于获得样品的生物体的基因组中的核酸序列。 本发明还涉及包含SEQ ID NO：1所示的核酸序列或由SEQ ID NO：1所示的核酸序列组成的寡核苷酸，以及包含本发明的寡核苷酸的试剂盒和至少一种：（i）缺少或具有 RNase H活性降低; （ii）DNA依赖性DNA合成抑制剂; （iii）RNase H; 和（iv）扩增cDNA的方法。

    COMPUTERIMPLEMENTIERTES VERFAHREN ZUR BEREITSTELLUNG EINER ANSTEUERSEQUENZ UND VERFAHREN ZUR ERFASSUNG VON MESSDATEN DURCH EINE MAGNETRESONANZEINRICHTUNG
    7.
    发明公开
    COMPUTERIMPLEMENTIERTES VERFAHREN ZUR BEREITSTELLUNG EINER ANSTEUERSEQUENZ UND VERFAHREN ZUR ERFASSUNG VON MESSDATEN DURCH EINE MAGNETRESONANZEINRICHTUNG 审中-公开

    公开(公告)号：EP3809151A1

    公开(公告)日：2021-04-21

    申请号：EP19202976.7

    申请日：2019-10-14

    申请人： Siemens Healthcare GmbH ,  Universitätsklinikum Erlangen

    发明人： Gumbrecht, Rene ,  Herrler, Jürgen ,  Liebig, Patrick ,  Nagel, Armin

    IPC分类号： G01R33/28 ,  G01R33/58 ,  G01R33/565 ,  G01R33/561

    摘要： Computerimplementiertes Verfahren zur Bereitstellung einer zu nutzenden Ansteuersequenz (25), die für eine Erfassung von Messdaten (32) eines Untersuchungsobjekts (2) durch eine Magnetresonanzeinrichtung (1) für mindestens einen Hochfrequenzsendekanal (5) einer Antennenanordnung (4) der Magnetresonanzeinrichtung (1) jeweilige abzustrahlende Sendesignale (29 - 31) vorgibt, umfassend die Schritte:
    - Bereitstellen von verschiedenen Ansteuersequenzen (16 - 18, 34), die jeweils das Ergebnis eines Optimierungsverfahrens (12) sind und sich bezüglich des Wertes eines im Rahmen des Optimierungsverfahrens berücksichtigten Optimierungsparameters (13 - 15, 47) unterscheiden,
    - Bereitstellen von mehreren durch die oder eine weitere Magnetresonanzeinrichtung (1) an dem Untersuchungsobjekt (2) erfassten Feldverteilungskarten (21), insbesondere wenigstens einer B 0 -Karte und/oder wenigstens einer B 1 -Karte,
    - Auswahl der zu nutzenden Ansteuersequenz (25) aus den verschiedenen Ansteuersequenzen (16 - 18, 34) in Abhängigkeit der Feldverteilungskarten (21) und Bereitstellung der zu nutzenden Ansteuersequenz (25).

    METHOD AND SYSTEM FOR ANALYZING HUMAN GAIT
    9.
    发明公开
    METHOD AND SYSTEM FOR ANALYZING HUMAN GAIT 审中-公开
    用于分析人类遗传算法的方法和系统

    公开(公告)号：EP3257437A1

    公开(公告)日：2017-12-20

    申请号：EP16174268.9

    申请日：2016-06-13

    申请人： Friedrich-Alexander-Universität Erlangen-Nürnberg ,  UNIVERSITÄTSKLINIKUM ERLANGEN ,  Astrum IT GmbH

    发明人： Barth, Jens ,  Eskofier, Bjoern ,  Hannink, Julius ,  Klucken, Jochen ,  Steidl, Ralph ,  Winkler, Jürgen

    IPC分类号： A61B5/00 ,  A61B5/11 ,  G06K9/00

    CPC分类号： A61B5/112 ,  A61B5/6807 ,  A61B5/7246 ,  A61B5/7267 ,  A61B2562/0219 ,  G06K9/00348

    摘要： The present invention relates to methods for analyzing gait of a subject. In particular, the present invention relates to a method for analyzing gait of a subject, said method comprising: providing data representing the 3D-movement of a foot of said subject over time; identifying within said data first data segments that each represent of at least one stride; determining one or more stride features for each of said first data segments; and defining one or more clusters on the basis of at least one stride feature of said one or more stride features. Each of the defined clusters represents a class of strides, e.g. a class may represent the typical stride of a subject. The present invention also provides for corresponding systems that are configured to perform the methods of the present invention and the use of these systems for analyzing in assessing gait of a subject, preferably a subject suffering from a movement-impairment.

    摘要翻译： 本发明涉及用于分析对象的步态的方法。 具体而言，本发明涉及一种用于分析对象的步态的方法，所述方法包括：随时间提供表示所述对象的脚部的3D运动的数据; 在所述数据内识别每个表示至少一个步幅的第一数据段; 为每个所述第一数据段确定一个或多个步幅特征; 以及基于所述一个或多个步幅特征的至少一个步幅特征来定义一个或多个集群。 每个定义的群集代表一类步幅，例如， 一个班级可能代表了一个学科的典型步伐。 本发明还提供了被配置为执行本发明的方法的相应系统以及这些系统用于评估受试者，优选患有运动障碍的受试者的步态的分析的用途。