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    MANNOSE-6-PHOSPHATE-BINDING ANTIBODIES AND THEIR USES
    2.
    发明公开
    MANNOSE-6-PHOSPHATE-BINDING ANTIBODIES AND THEIR USES 有权
    甘露糖-6-磷酸结合抗体及其应用

    公开(公告)号：EP2329267A1

    公开(公告)日：2011-06-08

    申请号：EP09781570.8

    申请日：2009-08-06

    申请人： Universitätsklinikum Hamburg-Eppendorf ,  Forschungszentrum Borstel

    发明人： BRAULKE, Thomas ,  MÜLLER-LOENNIES, Sven

    IPC分类号： G01N33/53 ,  C07K16/44 ,  C07K16/40

    CPC分类号： C07K16/44 ,  C07K16/40 ,  C07K2317/56 ,  C07K2317/565 ,  C07K2317/622 ,  C07K2317/92 ,  G01N33/66 ,  G01N33/6857 ,  G01N2400/02 ,  G01N2800/042

    摘要： The present invention relates to an isolated antibody or antigen-binding fragment thereof which specifically binds to mannose 6-phosphate and methods for preparing such antibody or antigen-binding fragment thereof. The invention further relates to a nucleic acid molecule encoding such antibody or antibody fragment, an expression vector comprising such nucleic acid molecule and a host cell comprising such nucleic acid molecule or expression vector. The invention also relates to a method for purifying or concentrating a target molecule comprising at least one mannose 6-phosphate residue from a sample. In another aspect, the invention relates to a method for diagnosing a disease which is characterized by an absent or reduced modification of molecules with mannose 6-phosphate residues. Finally, the invention relates to the use of an antibody or antibody fragment of the invention for use in medicine, in particular for the diagnosis of a disease which is characterized by an absent or reduced modification of molecules with mannose 6-phosphate residues.