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1.发明公开
公开(公告)号：EP3868894A1
公开(公告)日：2021-08-25
申请号：EP20158652.6
申请日：2020-02-21
IPC分类号： C12Q1/6883
摘要： The present invention relates in a first aspect to a method for diagnosing tuberculosis infection calculating a score based on the expression of a predetermined set of genes and as well as diagnosing or predicting the clinical outcome of the tuberculosis infection based on said score. In another aspect, a method for treatment monitoring and determining treatment duration in an individual with tuberculosis infection is provided. Said method includes the determination of the expression level of predetermined genes, calculating a value based thereon and the therapy monitoring or treatment monitoring and determining treatment duration in said individual accordingly. Moreover a method for determining the therapy-end of a treatment of tuberculosis infection in an individual affected with tuberculosis infection is provided. Said method includes the consideration of the expression level of predetermined genes together with the scores and values identified and calculating whether therapy is completed or not based on the value, the score and the expression level of said predetermined genes accordingly. In a further aspect, the use of a test kit or the use of kits of parts for conducting the methods according to the present invention is provided. Further, an array comprising means for detecting the expression of predetermined genes is identified as well as the use of the same. Moreover, a computer implemented method is provided as well as a computer readable medium or computer program product having computer executable instructions for performing the steps of the method disclosed herein.
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公开(公告)号：EP3416669A1
公开(公告)日：2018-12-26
申请号：EP17708179.1
申请日：2017-02-16
申请人： Forschungszentrum Borstel Leibniz-Zentrum für Medizin und Biowissenschaften , Freie Universität Berlin , Universität zu Lübeck , Rheinisch-Westfälische Technische Hochschule (RWTH) Aachen
发明人： BRANDENBURG, Klaus , HEINBOCKEL, Lena , REILING, Norbert , MARTINEZ DE TEJADA, Guillermo , SCHÜRHOLZ, Tobias , MAUSS, Karl , WEINDL, Günther
CPC分类号： C07K14/4723 , A61K38/00 , C07K7/08 , Y02A50/473
摘要： The present invention relates to a pharmaceutical composition comprising or consisting of a combination of (a) two or more peptides, each peptide consisting of or comprising 17 to 23 amino acids, wherein the amino acids in positions 1 to 23, counted from the N-terminus, are as follows (1) G, S or lacking; (2) C or lacking; (3) K or R; (4) K or R; (5) Y, W or F; (6) K or R; (7) K or R; (8) F, W or L; (9) K or R; (10) K or L or lacking; (11) W, L or F; (12) K or R; (13) F, Y or C; (14) K or R; (15) G or Q; (16) K or R; (17) F, L or W; (18) F or W; (19) F, L or W; (20) W or F; (21) C or lacking; (22) F or G or lacking; (23) G or lacking; or (b) one or more peptides, each peptide consisting of or comprising 17 to 23 amino acids, wherein the amino acids in positions 1 to 23, counted from the N-terminus, are as follows (1) G, S or lacking; (2) C or lacking; (3) K or R; (4) K or R; (5) Y, W or F; (6) K or R; (7) K or R; (8) F, W or L; (9) K or R; (10) K or L or lacking; (11 ) W, L or F; (12) K or R; (13) F, Y or C; (14) K or R; (15) G or Q; (16) K or R; (17) F, L or W; (18) F or W; (19) F, L or W; (20) W or F; (21) C or lacking; (22) F or G or lacking; (23) G or lacking, and one or more antibiotics selected from small organic molecule antibiotics such as ceftriaxone, oxacillin, amoxicillin, amikacin, ciprofloxacin, erythromycin, imipenem and tetracycline, and peptidic antibiotics such as daptomycin and vancomycin.
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公开(公告)号：EP2329267B1
公开(公告)日：2013-07-17
申请号：EP09781570.8
申请日：2009-08-06
CPC分类号： C07K16/44 , C07K16/40 , C07K2317/56 , C07K2317/565 , C07K2317/622 , C07K2317/92 , G01N33/66 , G01N33/6857 , G01N2400/02 , G01N2800/042
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公开(公告)号：EP2542286B1
公开(公告)日：2017-09-27
申请号：EP11704937.9
申请日：2011-02-18
发明人： RÜLLER, Stephan , GREVE, Susanne
CPC分类号： A61M16/00 , A61M16/0069 , A61M16/024 , A61M16/201 , A61M2016/0021 , A61M2016/0027 , A61M2016/0039
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5.发明公开METHOD FOR SYNTHETICALLY PRODUCING ARABINOGALACTAN COMPOUNDS DERIVED FROM PLANTS AND USES OF SAID COMPOUNDS FOR THE PROPHYLAXIS OF ALLERGIC REACTIONS 审中-公开处理综合ARABINOGALACTANVERBINDUNGEN的制剂，其来源是植物和化合物的使用过敏反应的预防
公开(公告)号：EP3176175A1
公开(公告)日：2017-06-07
申请号：EP15197381.5
申请日：2015-12-01
申请人： Protectimmun GmbH , Ruhr-Universität Bochum , Forschungszentrum Borstel Leibniz-Zentrum für Medizin und Biowissenschaften
发明人： Peters, Marcus , Holst, Otto , Vogel, Christian , Voss, Alice
IPC分类号： C07H15/04 , A61K31/7028 , A61P29/00
CPC分类号： C07H15/04 , A61K31/7028
摘要： The present invention relates to L-arabino-oligosaccharides, in particular synthetically produced L-arabino-oligosaccharides and their uses for the prophylaxis of allergic reactions in mammals.
摘要翻译： 本发明涉及-L-阿糖 - 寡糖，尤其是合成制备的L-阿拉伯 - 寡糖及其在哺乳动物过敏反应的预防用途。
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公开(公告)号：EP1945798B1
公开(公告)日：2013-05-22
申请号：EP06818332.6
申请日：2006-10-31
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7.发明公开KIT COMPRISING 2,4-DICHLOROPHENOXYACETIC ACD DERIVATIVES AND ANTIBODIES FOR HIGHLY SENSITIVE DETECTION ASSAYS 审中-公开2,4-二氯苯氧衍生物和抗体高灵敏度检测测试套件
公开(公告)号：EP1971864A2
公开(公告)日：2008-09-24
申请号：EP06806648.9
申请日：2006-10-31
IPC分类号： G01N33/532 , G01N33/58 , C07D207/46 , C07C49/753 , C07H17/00 , C07H21/00
CPC分类号： G01N33/582 , C07D207/46 , C07K16/44 , G01N33/532
摘要： The present invention relates to kits comprising 2,4-dichlorophenoxyacetate derivatives as well as antibodies that bind to these derivatives. Inter alia, the kits can be used to label biomolecules for analytical and diagnostic applications. Some of the compounds described here can be used to label biomolecules under physiological conditions and without having to apply in situ activation. Furthermore, the presence of spacers within the 2,4-dichlorophenoxyacetate derivatives improves their binding to antibodies.
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公开(公告)号：EP1080192A2
公开(公告)日：2001-03-07
申请号：EP99926337.9
申请日：1999-05-20
CPC分类号： C12N15/113 , A61K38/00 , C12N2310/315
摘要： The invention relates to oligoribo- and oligodesoxyribonucleotides which are suitable for treating pathological conditions that are accompanied by increased cell proliferation. Said oligoribo- and oligodesoxyribonucleotides are characterised in that they are able to hybridise with the mRNA which codes the protein Ki-67, this protein being associated with the cell cycle.
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9.发明公开Kombinationspräparate für die Therapie von Tumoren 审中-公开Kombinationspräparatefürdie Therapie von Tumoren
公开(公告)号：EP0919244A2
公开(公告)日：1999-06-02
申请号：EP98250357.5
申请日：1998-10-09
IPC分类号： A61K45/06
CPC分类号： A61K31/40 , A61K31/55 , A61K38/13 , A61K31/35 , A61K31/395 , A61K2300/00
摘要： Die Erfindung betrifft Erzeugnisse, die einen Hemmer cyclinabhängiger Proteinkinasen und einen oder mehrere Modulatoren mindestens eines weiteren proteinmodifizierenden Enzyms als Kombinationspräparat zur gleichzeitigen, getrennten oder zeitlich abgestuften Anwendung als Arzneimittel enthalten. Die Erzeugnisse eignen sich insbesondere zu Anwendung in der Tumortherapie.
摘要翻译： 要求保护作为药物的同时，分开或顺序施用的组合制剂的（a）细胞周期蛋白依赖性蛋白激酶抑制剂和（b）至少一种其它蛋白质修饰酶的一种或多种调节剂的产品。
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10.发明公开
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