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1.发明授权Radiopaque, non-biodegradable, water-insoluble iodinated benzyl ethers of poly(vinyl alcohol), preparation method thereof, injectable embolizing compositions containing thereof and use thereof 有权，不可降解的，wasserunlösslichen无线电不透明，碘化polyvinylakoholbenzyläther，使得，iniektierbaren栓塞组合物和它们的使用方法。
公开(公告)号：EP2545085B1
公开(公告)日：2016-10-19
申请号：EP11707664.6
申请日：2011-03-09
申请人： Université Claude Bernard Lyon 1 (UCBL) , Centre National de la Recherche Scientifique (CNRS) , Antia Therapeutics S.A.
发明人： CHEVALIER, Yves , AGUSTI, Géraldine , NYFFENEGGER, Coralie , DOELKER, Eric , JORDAN, Olivier , ANDERSEN, Gert
IPC分类号： C08F8/18 , A61L24/00 , C09D129/04 , A61K49/04 , A61L31/10
CPC分类号： C08F116/06 , A61K49/0442 , A61L24/043 , A61L24/06 , A61L2400/06 , A61L2430/36 , C08F8/18 , C08F16/06 , C08L29/04 , C08L27/10
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2.发明公开RADIOPAQUE, NON- BIODEGRADABLE, WATER - INSOLUBLE IODINATED BENZYL ETHERS OF POLY (VINYL ALCOHOL), PREPARATION METHOD THEREOF, INJECTABLE EMBOLIZING COMPOSITIONS CONTAINING THEREOF AND USE THEREOF 有权，不可降解的，wasserunlösslichen无线电不透明，碘化polyvinylakoholbenzyläther，使得，iniektierbaren栓塞组合物和它们的使用方法。
公开(公告)号：EP2545085A1
公开(公告)日：2013-01-16
申请号：EP11707664.6
申请日：2011-03-09
申请人： Université Claude Bernard Lyon 1 (UCBL) , Centre National de la Recherche Scientifique CNRS , Antia Therapeutics S.A.
发明人： CHEVALIER, Yves , AGUSTI, Géraldine , NYFFENEGGER, Coralie , DOELKER, Eric , JORDAN, Olivier , ANDERSEN, Gert
IPC分类号： C08F8/18 , A61L24/00 , C09D129/04 , A61K49/04 , A61L31/10
CPC分类号： C08F116/06 , A61K49/0442 , A61L24/043 , A61L24/06 , A61L2400/06 , A61L2430/36 , C08F8/18 , C08F16/06 , C08L29/04 , C08L27/10
摘要： The invention concerns a radiopaque, non-biodegradabie, water-insoluble iodinated benzyl ether of polyvinyl alcohol) consisting of a PVA having covalentiy grafted thereon iodinated benzyl groups comprising 1 - 4 iodine atoms per benzyl group, a process for preparing the same comprising reacting a 0 - 100 % hydrolyzed PVA with a iodinated benzyl derivative comprising 1 - 4 iodine atoms per benzyl group in a polar aprotic solvent in the presence of a base in anhydrous conditions. Said iodo-benzylether-PVA is particularly useful as embolic agent in an injectable embolizing composition. The invention also concerns an injectable embolizing composition comprising said iodo-benzylether-PVA and capable of forming a cohesive mass upon contact with a body fluid by precipitation of the iodo- benzylether-PVA. Said injectable embolizing composition is particularly useful for forming in-situ a cohesive mass in a blood vessel or into a tumor. The invention further concerns a coating composition containing said iodo-benzylether-PVA and capable of forming a radiopaque coating on a medical device. The invention further concerns particles formed of said iodo-benzylether-PVA.
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