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公开(公告)号：EP1368075A1
公开(公告)日：2003-12-10
申请号：EP02703423.0
申请日：2002-02-28
申请人： Université Laval
发明人： LAROCHE, Gaétan , MANTOVANI, Diego , CHEVALLIER, Pascale , CASTONGUAY, Martin , PAGEAU, Jean-François
CPC分类号： A61L33/0011 , A61F2/06 , A61L33/0076 , A61L33/0094 , B29C59/142
摘要： In accordance with the present invention, there is provided a novel process for modifying the surface properties of a material that is suitable for contact with animal tissue so as to enhance its hemocompatibility and make it less thrombogenic when in use. This process comprises: Exposing the surface of the material to plasma treatment conditions in order to create reactive groups on said surface; activating a molecule with an activator to produce a reactive molecular species capable of forming convalent bonds with the reactive groups created on the surface of the material to form convalent bonds. The invention further encompasses the materials produced by this process as well as devices, such as vascular prosthesis, that are comprised of these process-modified materials.
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公开(公告)号：EP1368075B1
公开(公告)日：2006-04-12
申请号：EP02703423.0
申请日：2002-02-28
申请人： Université Laval
发明人： LAROCHE, Gaétan , MANTOVANI, Diego , CHEVALLIER, Pascale , CASTONGUAY, Martin , PAGEAU, Jean-François
CPC分类号： A61L33/0011 , A61F2/06 , A61L33/0076 , A61L33/0094 , B29C59/142
摘要： In accordance with the present invention, there is provided a novel process for modifying the surface properties of a material that is suitable for contact with animal tissue so as to enhance its hemocompatibility and make it less thrombogenic when in use. This process comprises: Exposing the surface of the material to plasma treatment conditions in order to create reactive groups on said surface; activating a molecule with an activator to produce a reactive molecular species capable of forming convalent bonds with the reactive groups created on the surface of the material to form convalent bonds. The invention further encompasses the materials produced by this process as well as devices, such as vascular prosthesis, that are comprised of these process-modified materials.
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