公开(公告)号：EP3865471A1

公开(公告)日：2021-08-18

申请号：EP20156678.3

申请日：2020-02-11

申请人： Université Libre de Bruxelles

发明人： BRUYLANTS, Gilles ,  JABIN, Ivan ,  RETOUT, Maurice

IPC分类号： C07C217/94 ,  C07C245/20 ,  C07D333/50 ,  C08J7/04 ,  A61K47/58 ,  A61K47/62 ,  A61K47/69

摘要： This invention concerns a versatile and simple one-pot method to prepare nanomaterials, and in particular nanoparticles, grafted with an ultra-thin layer of calixarenes by placing at least one oxidized metal with at least one calix[n]arene diazonium salt in the presence of a reducing agent in a solvent, and heating the reaction mixture to obtain a metal-based nanomaterial coated with calix[n]arenes. The invention further concerns the use of these calixarene-grafted nanomaterials to further functionalize the surface of the nanomaterials.

公开(公告)号：EP2836539A1

公开(公告)日：2015-02-18

申请号：EP13712586.0

申请日：2013-03-28

申请人： Université Libre de Bruxelles (ULB) ,  Centre National de la Recherche Scientifique (CNRS) ,  Université de Rennes I ,  Université Paris Descartes

发明人： JABIN, Ivan ,  MATTIUZZI, Alice ,  LAGROST, Corinne ,  HAPIOT, Philippe ,  REINAUD, Olivia

IPC分类号： C08J7/04 ,  C07D498/22 ,  B01J31/06

摘要： A calixarene directly grafted onto the surface of a material, a related grafting process, and certain calixarene intermediates useful for carrying out the grafting process.

摘要翻译： 本发明涉及杯芳烃主要直接接枝到材料的表面以及接枝方法上，以及可用于承载接枝过程的某些杯芳烃中间体。

公开(公告)号：EP4103541A1

公开(公告)日：2022-12-21

申请号：EP21704274.6

申请日：2021-02-10

申请人： Université Libre de Bruxelles

发明人： BRUYLANTS, Gilles ,  JABIN, Ivan ,  RETOUT, Maurice ,  GOSSELIN, Bryan

IPC分类号： C07C217/94 ,  C07C245/20 ,  C07D333/50 ,  C08J7/04 ,  A61K47/58 ,  A61K47/62 ,  A61K47/69

公开(公告)号：EP4406939A1

公开(公告)日：2024-07-31

申请号：EP23305100.2

申请日：2023-01-26

申请人： Université Grenoble Alpes ,  Université Libre de Bruxelles ,  Centre National de la Recherche Scientifique ,  Institut National de la Santé et de la Recherche Médicale ,  Centre Hospitalier Régional de Grenoble ,  COMMISSARIAT À L'ÉNERGIE ATOMIQUE ET AUX ÉNERGIES ALTERNATIVES

发明人： BUSSER, Benoît ,  DENIAUD, Aurélien ,  LELIEVRE, Pierre ,  SANCEY GALLIOT, Lucie ,  RENIER, Nathan ,  VALKENIER-VAN DIJK, Elisabeth H. ,  JABIN, Ivan

IPC分类号： C07D233/64 ,  C07D235/12 ,  C07D263/32 ,  C07D277/24 ,  A61P35/00 ,  A61K31/4164

CPC分类号： C07D233/64 ,  C07D235/12 ,  C07D263/32 ,  C07D277/24 ,  A61P35/00

摘要： The present invention relates to calix[4]arenes of the formula (1),

in which:
Y1, Y2, Y3 and Y4 are selected from the group consisting of hydrogen, NO2, amine, azide, halogen, triazole and C1-C8-alkyl group, X1, X2, X3 and X4 are selected from the group consisting of CH2 and S, Z is a heterocyclic moiety which is selected from the group consisting of imidazole, benzimidazole, benzothiazole, benzoxazole, purine, oxazole, triazole, pyrazole and thiazole, R1, R2 and R3 are selected from the group consisting -(CH2)nZ, hydrogen and C1-C8-alkyl group, n being an integer comprised between 1 and 4. They exhibit high cytotoxicity against cancer cells.