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    SYSTEME D'EXPRESSION AUTO-INDUCTIBLE
    2.
    发明公开
    SYSTEME D'EXPRESSION AUTO-INDUCTIBLE 审中-公开
    SYSTEME D'EXPRESSION自动感应

    公开(公告)号：EP3198002A1

    公开(公告)日：2017-08-02

    申请号：EP15766181.0

    申请日：2015-09-21

    申请人： Université de Bourgogne ,  INRA ,  INSERM

    发明人： NEIERS, Fabrice ,  SEIGNEURIC, Renaud ,  BRIAND, Loïc ,  GARRIDO-FLEURY, Carmen

    IPC分类号： C12N1/20 ,  C12N15/72 ,  C12P21/02 ,  C07K14/47 ,  C12R1/19

    摘要： The present invention relates in particular to a method for the expression of a protein of interest by a bacterium, notable in that it comprises the culturing of a bacterium temporarily or continuously expressing an Hsp protein, in that said bacterium also comprises a nucleic acid sequence, encoding a protein of interest, under the control of a lac promoter and in that said bacterium is cultured in a medium which does not contain IPTG or a metabolized molecule in such a way as to automatically induce the induction of transcription from the lac promoter.

    摘要翻译： 本发明特别涉及用于由细菌表达目的蛋白质的方法，其特征在于它包括暂时或连续表达Hsp蛋白质的细菌的培养，因为所述细菌还包含核酸序列， 在lac启动子的控制下编码感兴趣的蛋白质，并且所述细菌在不含有IPTG或代谢分子的培养基中以自动诱导从lac启动子诱导转录的方式培养。

    METHODS AND COMPOSITIONS FOR DIAGNOSING, MONITORING AND TREATING CANCER
    4.
    发明公开
    METHODS AND COMPOSITIONS FOR DIAGNOSING, MONITORING AND TREATING CANCER 审中-公开
    方法和组合物用于诊断，监测和治疗癌症的

    公开(公告)号：EP3155431A1

    公开(公告)日：2017-04-19

    申请号：EP15728015.7

    申请日：2015-06-12

    申请人： INSERM (Institut National de la Santé et de la Recherche Médicale) ,  Université de Bourgogne

    发明人： GARRIDO-FLEURY, Carmen ,  GOBBO, Jessica ,  SEIGNEURIC, Renaud ,  MARCION, Guillaume

    IPC分类号： G01N33/574

    CPC分类号： G01N33/57488 ,  A61K38/08 ,  G01N2333/47

    摘要： The invention relates to methods for diagnosing cancer and determining the responsiveness to chemotherapyin a subject based on the detection of HSP70-expressing exosomes in a bodily fluid sample obtained from said subject. The invention also relates to methods for treating cancer and in particular methods for restoring or enhancing the anti-tumor immune response in a patient in need thereof by inhibiting the activation MDSC as well as methods for inhibiting or reducing HSP70-expressing exosomes-mediated tumor resistance against a chemotherapeutic agent and therefore methods for restoring or enhancing the efficacy of said chemotherapeutic agent.

    摘要翻译： 本发明涉及用于诊断癌症和确定性采矿的响应到chemotherapyin基于表达从所述受试者获得的体液样品中的外泌体的检测HSP70的受试者的方法。 因此，本发明涉及的方法用于治疗癌症和在用于恢复或通过抑制活化MDSC以及用于抑制或减少HSP70表达的方法提高在有需要的患者的抗肿瘤免疫应答的具体方法的外来体介导的肿瘤抗性 对化学治疗剂和用于恢复或增强化疗剂的功效的方法THEREFORE所述。