公开(公告)号：EP3960203A1

公开(公告)日：2022-03-02

申请号：EP20192755.5

申请日：2020-08-25

申请人： Université de Liège

发明人： GRANDFILS, Christian ,  SEVRIN, Chantal

IPC分类号： A61K47/58

摘要： The invention provides a complex comprising at least one proteinaceous agent, an ionic polymer comprising a repetitive unit of formula (I):

wherein R 1 represents a hydrogen atom or a straight or branched chain alkyl group, preferably a straight or branched chain alkyl group comprising from 1 to 6 carbon atoms, for example a methyl group; R 2 represents a straight or branched chain alkyl group which is substituted by a group which may have a positive charge at a physiological pH; and optionally a surfactant; a complex for use in a method of medical treatment; a pharmaceutical composition

公开(公告)号：EP1664771A2

公开(公告)日：2006-06-07

申请号：EP04766652.4

申请日：2004-08-31

申请人： Université de Liège

发明人： GRANDFILS, Christian ,  DANDRIFOSSE, Guy ,  REMACLE, René ,  BARAKAT, Ibrahim ,  DELOYER, Patricia

IPC分类号： G01N33/52 ,  G01N31/22

CPC分类号： G01N33/52 ,  G01N31/22

摘要： The subject matter of the present invention relates a method for detection of polyethylene glycols (PEG) in an aqueous solution or in a sample of a biological fluid in a qualitative and/or semi-quantitative and/or quantitative manner, the method comprising the addition of a reagent containing iodine, alkali metal iodide and an acid; and a method for assessing the permeability of the intestine wherein two PEGs of different molecular weight, low molecular weight PEG (l.m.w. PEG) and high molecular weight PEG (h.m.w. PEG) are used as markers, wherein the l.m.w. PEG is able to cross the intestinal mucosa under physiological conditions and the h.m.w. PEG is essentially not able to cross the intestinal mucosa under physiological conditions, but is able to cross the intestinal mucosa under non-physiological, irregular conditions; and wherein h.m.w. and l.m.w. PEG concentrations are measured in a sample of urine from an individual after oral administration of h.m.w. PEG and l.m.w. PEG, wherein the differential index of h.m.w. PEG and l.m.w. PEG in the urine is calculated after determining the concentrations of h.m.w. PEG and l.m.w. PEG by using a reagent for quantitative detection of polyethylene glycol (PEG) in biological fluids, the reagent containing iodine, alkali metal iodide and an acid; and a kit for qualitative and/or semi-quantitative and/or quantitative detection of polyethylene glycol in biological fluids, e.g. in urine.

公开(公告)号：EP3038603B1

公开(公告)日：2018-08-01

申请号：EP14749826.5

申请日：2014-08-08

申请人： Université de Liège

发明人： GRANDFILS, Christian ,  FLEBUS, Lucas ,  SEVRIN, Chantal

IPC分类号： A61K9/19 ,  A61K31/727 ,  A61K31/78 ,  A61K31/785 ,  A61K47/34 ,  A61P39/02

CPC分类号： A61K31/785 ,  A61K9/0019 ,  A61K31/727 ,  A61K31/78 ,  A61K47/34 ,  B01J41/14 ,  C08F120/34 ,  A61K2300/00

摘要： A polymer of formula (I): where X 1 and X 2 respectively represent the alpha and omega end groups of the polymer; R 1 represents a hydrogen atom or a straight or branched chain alkyl group; R 2 represents a straight or branched chain alkyl group which is substituted by a group which may have a positive charge at physiological pH; and n represents the number of repetitive units of the polymer; or a copolymer thereof; for use as a medicament and for treatment of a heparin overdose wherein the polymer of formula (I) has been found to have a selectivity and affinity for heparin.

公开(公告)号：EP3038603A1

公开(公告)日：2016-07-06

申请号：EP14749826.5

申请日：2014-08-08

申请人： Université de Liège

发明人： GRANDFILS, Christian ,  FLEBUS, Lucas ,  SEVRIN, Chantal

IPC分类号： A61K9/19 ,  A61K31/727 ,  A61K31/78 ,  A61K31/785 ,  A61P39/02

CPC分类号： A61K31/785 ,  A61K9/0019 ,  A61K31/727 ,  A61K31/78 ,  A61K47/34 ,  B01J41/14 ,  C08F120/34 ,  A61K2300/00

摘要： A polymer of formula (I): where X 1 and X 2 respectively represent the alpha and omega end groups of the polymer; R 1 represents a hydrogen atom or a straight or branched chain alkyl group; R 2 represents a straight or branched chain alkyl group which is substituted by a group which may have a positive charge at physiological pH; and n represents the number of repetitive units of the polymer; or a copolymer thereof; for use as a medicament and for treatment of a heparin overdose wherein the polymer of formula (I) has been found to have a selectivity and affinity for heparin.

摘要翻译： 式（I）的聚合物：其中X 1和X 2分别表示聚合物的α和ω端基; R 1表示氢原子或直链或支链烷基; R 2表示在生理pH下可以具有正电荷的基团取代的直链或支链烷基; n表示聚合物的重复单元数; 或其共聚物; 用作药物和用于治疗肝素过量，其中已经发现式（I）的聚合物对肝素具有选择性和亲和力。