Polymeric synthetic antidote
    4.
    发明公开
    Polymeric synthetic antidote 审中-公开
    Neues合成Gegengift

    公开(公告)号:EP2842548A1

    公开(公告)日:2015-03-04

    申请号:EP13182277.7

    申请日:2013-08-29

    摘要: A polymer of formula (I):

    where X 1 and X 2 respectively represent the alpha and omega end groups of the polymer;
    R 1 represents a hydrogen atom or a straight or branched chain alkyl group;
    R 2 represents a straight or branched chain alkyl group which is substituted by a group which may have a positive charge at physiological pH; and
    n represents the number of repetitive units of the polymer;
    or a copolymer thereof;
    for use as a medicament and for treatment of a heparin overdose wherein the polymer of formula (I) has been found to have a selectivity and affinity for heparin.

    摘要翻译: 式(I)的聚合物:其中X 1和X 2分别表示聚合物的α和ω端基; R 1表示氢原子或直链或支链烷基; R 2表示在生理pH下可以具有正电荷的基团取代的直链或支链烷基; n表示聚合物的重复单元数; 或其共聚物; 用作药物和用于治疗肝素过量,其中已经发现式(I)的聚合物对肝素具有选择性和亲和力。

    HYDROLYTISCH ABBAUBARE IONISCHE COPOLYMERISATE
    5.
    发明公开
    HYDROLYTISCH ABBAUBARE IONISCHE COPOLYMERISATE 审中-公开
    水解降解离子共聚物

    公开(公告)号:EP2265648A1

    公开(公告)日:2010-12-29

    申请号:EP09733031.0

    申请日:2009-04-09

    摘要: The present invention provides novel hydrolytically decomposable ionic copolymers. These ionic copolymers are made up of a cyclic ketene acetal A, an anionic or cationic methacrylic acid derivative B selected from 2-methyl-methacrylate, [2-(2-methyl-1-methylen-allyloxy)-ethane sulfonate, [2-(2-methyl-1-methylen-allyloxy)ethyl]-phosphonate or a quaternary amine of N,N-dimethylaminoethylmethacrylic acid (DMAEMA) and optionally a neutral methacrylic acid derivative C. According to the invention, hydrolytically decomposable ionic copolymers are produced by polymerizing the components A, B and C in the presence of a radical starter under a protective gas atmosphere, followed by purification. All copolymers according to the invention are hydrolytically decomposable. Copolymers containing a maximum of 40 mol-% of ester groupings in the backbone are also biodegradable, wherein in the case of cationic copolymers a maximum of 20 mol-% quaternized DMAEMA may be present. Cationic copolymers containing at least 50 mol-% of component B are antimicrobial. Both anionic as well as cationic copolymers are suitable for the production of nanoparticles. Cationic copolymers can be used a superhydrophobic materials as well as adhesives. Anionic copolymers are suitable as biodegradable thermoplastic elastomers and as biodegradable ionomers.

    A DRAW SOLUTE FOR FORWARD OSMOSIS
    6.
    发明公开
    A DRAW SOLUTE FOR FORWARD OSMOSIS 审中-公开
    GELÖSTEZUGSUBSTANZFÜRVORWÄRTSOSMOSE

    公开(公告)号:EP2988853A1

    公开(公告)日:2016-03-02

    申请号:EP14787762.5

    申请日:2014-04-28

    IPC分类号: B01D61/00 C02F1/44

    摘要: The present invention provides a draw solute for forward osmosis comprising a carbon dioxide responsive structural unit and a thermally responsive structural unit, wherein the draw solute is capable of reversibly switching between a protonated state and a deprotonated state. The present invention also provides a forward osmosis method utilising the draw solute.

    摘要翻译: 本发明提供了一种用于正向渗透的牵伸溶质,其包括二氧化碳响应结构单元和热响应结构单元,其中所述拉伸溶质能够在质子化状态和去质子化状态之间可逆地切换。 本发明还提供了利用拉伸溶质的正向渗透法。