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    RADIOTRACEUR NOTAMMENT POUR LA MALADIE D'ALZHEIMER
    2.
    发明公开
    RADIOTRACEUR NOTAMMENT POUR LA MALADIE D'ALZHEIMER 有权
    RADIOTRACER，INSBESONDEREFÜRMORBUS ALZHEIMER

    公开(公告)号：EP2847154A1

    公开(公告)日：2015-03-18

    申请号：EP13714296.4

    申请日：2013-04-04

    申请人： Université de Lorraine ,  Centre National de la Recherche Scientifique (CNRS)

    发明人： CHAPLEUR, Yves ,  LAMANDE-LANGLE, Sandrine ,  COLLET, Charlotte ,  CHRETIEN, Françoise

    IPC分类号： C07C35/16 ,  A61K31/047 ,  A61P25/28

    CPC分类号： C07C41/30 ,  A61K31/047 ,  A61K51/04 ,  C07B59/005 ,  C07B2200/05 ,  C07C29/00 ,  C07C29/095 ,  C07C29/1285 ,  C07C41/16 ,  C07C41/26 ,  C07C43/188 ,  C07C43/196 ,  C07C67/03 ,  C07C67/08 ,  C07C67/287 ,  C07C67/29 ,  C07C67/297 ,  C07C69/16 ,  C07C69/33 ,  C07C309/73 ,  C07C2601/14 ,  Y02P20/55 ,  C07C35/14 ,  C07C69/63 ,  C07C35/48 ,  C07C69/145 ,  C07C43/192

    摘要： The invention relates to a compound of formula (I), where: n is an integer equal to 0 or 1; R1 is, when n=0, an alkyl chain having 3 to 6 carbon atoms, an alkenyl chain, alkylene, a linear hydroxyalkyl chain having 2 to 6 carbon atoms, the hydroxyl function optionally being protected or the oxygen of said function being substituted so as to form a leaving group, a halogenoalkyl chain having 2 to 6 carbon atoms, the halogen optionally being radioactive, or a fluoromethyl group, the fluorine optionally being radioactive, and when n=1, a monohydroxyalkyl chain having 1 to 6 carbon atoms, the hydroxyl function, at the terminal position, optionally being protected or the oxygen of said function being substituted so as to form a leaving group, or monohalogenoalkyl having 1 to 6 carbon atoms, the halogen at the terminal position optionally being radioactive, wherein the halogen is not bromine; P
    1 is, when n=0, hydrogen or a group protecting the hydroxyl function, identical or different, when n=1 and R1 is a monohydroxyalkyl chain, hydrogen or a group protecting the hydroxyl function, identical or different, and when n=1 and R1 is a monohalogenalkyl chain, hydrogen or a group protecting the hydroxyl function, identical or different; Y
    1 is, when n=0, an OP
    1 group, where P
    1 is as defined above, or, when n=1, a hydrogen atom, with the exception of the non-radiolabeled 2-fluoromethyl-
    myo -inositol compounds for which P
    1 , identical or different, is a hydrogen atom or a benzyl protecting group, and to the use thereof as a drug.

    摘要翻译： 本发明涉及式（I）化合物，其中：n为等于0或1的整数; 当n = 0时，R 1为具有3至6个碳原子的烷基链，烯基链，亚烷基，具有2至6个碳原子的直链羟烷基链，任选被保护的羟基官能团或所述官能团的氧被取代为 为了形成离去基团，具有2至6个碳原子的卤代烷基链，卤素任选是放射性的，或氟甲基，氟任选地是放射性的，当n = 1时，具有1至6个碳原子的单羟基烷基链， 羟基官能团，末端位置，任选地被保护，或者所述官能团的氧被取代以形成离去基团，或具有1至6个碳原子的单卤代烷基，末端位置的卤素任选地是放射性的，其中卤素 不是溴; 当n = 0时，当n = 1时，当n = 0时，氢或保护羟基官能团的基团相同或不同，当n = 1且R 1为单羟基烷基链时，氢或保护羟基官能团的基团相同或不同，并且当n = 1时 R1是一卤代烷基链，氢或保护羟基官能团的基团相同或不同; 当n = 0时，Y1是OP1基团，其中P1如上所定义，或者当n = 1时，除了非放射性标记的2-氟甲基肌醇化合物之外，其中P1， 相同或不同的是氢原子或苄基保护基，以及作为药物的用途。