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公开(公告)号：EP4188396A1
公开(公告)日：2023-06-07
申请号：EP21758336.8
申请日：2021-08-02
申请人： Université de Montpellier , INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE - INSERM , Centre Hospitalier Universitaire de Montpellier (CHUM) , ICM (Institut de Cancerologie de Montpellier)
发明人： VILLALBA, Martin , JORGENSEN, Christian , ROBERT, Bruno , MARTINEAU, Pierre , HERNANDEZ, Francisco Javier , PRESUMEY, Jessy
IPC分类号： A61K35/17 , A61K39/395 , C07K16/32 , C12N5/0783 , A61P35/00
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公开(公告)号：EP3532502A1
公开(公告)日：2019-09-04
申请号：EP17797084.5
申请日：2017-10-25
申请人： INSERM (Institut National de la Santé et de la Recherche Médicale) , Université Paris Diderot - Paris 7 , Université de Montpellier , Institut Jean Godinot , Institut Regional du Cancer de Montpellier
发明人： BENSUSSAN, Armand , ROBERT, Bruno , MARTINEAU, Pierre , CHENTOUF, Myriam , MARIE-CARDINE, Anne , GUSTINIANI, Jérôme
IPC分类号： C07K16/28
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公开(公告)号：EP3245229A1
公开(公告)日：2017-11-22
申请号：EP16700495.1
申请日：2016-01-14
申请人： INSERM - Institut National de la Santé et de la Recherche Médicale , Université Paris Diderot - Paris 7 , Institut Regional du Cancer de Montpellier , Université de Montpellier
发明人： COUVINEAU, Alain , VOISIN, Thierry , NICOLE, Pascal , ROBERT, Bruno , MARTINEAU, Pierre , CHENTOUF, Myriam
CPC分类号： C07K16/286 , A61K2039/505 , C07K16/30 , C07K2317/21 , C07K2317/73
摘要： The present disclosure relates to human monoclonal antibodies against orexin receptor type 1 (OX1R, hyprocretin 1) and uses thereof for the treatment of cancer. The antibodies are characterized by their CDRs: NYYMN, YISGSSRNIYYADFVKG, SNYDGMDV (Heavy chain) and AGTSSDVGGSNYVS, PGKAP, SSYTYYSTRV (Light Chain)) or the CDRS having at least 50% or 70% identity with the above listed sequences.
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公开(公告)号：EP3229836A1
公开(公告)日：2017-10-18
申请号：EP15805233.2
申请日：2015-12-08
申请人： Institut National de la Santé et de la Recherche Médicale (INSERM) , Université de Montpellier , Institut Regional du Cancer de Montpellier
IPC分类号： A61K39/395 , C07K16/28 , A61K39/00
摘要： The present disclosure provides human monoclonal antibodies and antibody-drug conjugates against AXL and their use for the treatment of cancer.
摘要翻译： 本公开提供了针对AXL的人单克隆抗体和抗体 - 药物偶联物及其用于治疗癌症的用途。
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5.发明公开HUMAN MONOCLONAL ANTIBODIES FRAGMENTS INHIBITING BOTH THE CATH-D CATALYTIC ACTIVITY AND ITS BINDING TO THE LRP1 RECEPTOR 审中-公开人单克隆抗体片段抑制CATH-D催化活性及其与LRP1受体的结合
公开(公告)号：EP3298044A1
公开(公告)日：2018-03-28
申请号：EP16723779.1
申请日：2016-05-20
申请人： INSERM (Institut National de la Santé et de la Recherche Médicale) , Université de Montpellier , Institut Regional du Cancer de Montpellier
CPC分类号： C07K16/3015 , A61K2039/505 , A61P35/00 , C07K16/40 , C07K2317/21 , C07K2317/76
摘要： The invention relates to human anti-Cath-D neutralizing monoclonal antibodies and uses thereof. More particularly, the invention relates to an isolated human monoclonal antibody or a fragment thereof comprising a heavy chain variable region comprising SEQ ID NO: 2 in the H-CDR1 region, SEQ ID NO: 3 in the H-CDR2 region and SEQ ID NO: 4 in the H-CDR3 region; and a light chain variable region comprising SEQ ID NO: 6 in the L-CDR1 region, SEQ ID NO: 7 in the L-CDR2 region and SEQ ID NO: 8 in the L-CDR3 region. The invention also relates to an isolated human monoclonal antibody or a fragment thereof comprising a heavy chain variable region comprising SEQ ID NO: 10 in the H-CDR1 region, SEQ ID NO: 11 in the H-CDR2 region and SEQ ID NO: 12 in the H-CDR3 region; and a light chain variable region comprising SEQ ID NO: 14 in the L-CDR1 region, SEQ ID NO: 15 in the L-CDR2 region and SEQ ID NO: 16 in the L-CDR3 region.
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6.发明授权PROCEDE D'IDENTIFICATION D'UN LIGAND CAPABLE DE MODULER SELECTIVEMENT UNE CASCADE FONCTIONNELLE IMPLIQUANT UNE CIBLE, ET SES APPLICATIONS POUR LE CRIBLAGE A HAUT-DEBIT DE MOLECULES D'INTERET. 有权对于功能CASCADE MODULATE CAN并在选择性配目标暗示的检测方法及其使用的利益分子的高通量筛选
公开(公告)号：EP1743178B1
公开(公告)日：2010-06-16
申请号：EP05762419.9
申请日：2005-04-25
申请人： Centre National de la Recherche Scientifique , Université de Montpellier I , Universite de Montpellier II
IPC分类号： G01N33/68
CPC分类号： G01N33/6854 , C07K2317/622 , C12Q1/025 , G01N33/5041 , G01N33/686 , G01N33/6872 , G01N2500/00
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公开(公告)号：EP4034560A1
公开(公告)日：2022-08-03
申请号：EP20781351.0
申请日：2020-09-25
申请人： INSERM (Institut National de la Santé et de la Recherche Médicale) , Institut Regional du Cancer de Montpellier , Université de Montpellier , Sorbonne Université
发明人： PELEGRIN, André , ROBERT, Bruno , MARTINEAU, Pierre , CHAUVIN, Maëva , CHENTOUF, Myriam , DI CLEMENTE-BESSE, Nathalie
IPC分类号： C07K16/26 , A61P35/00 , A61K39/395
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8.发明公开PROCEDE D'IDENTIFICATION D'UN LIGAND CAPABLE DE MODULER SELECTIVEMENT UNE CASCADE FONCTIONNELLE IMPLIQUANT UNE CIBLE, ET SES APPLICATIONS POUR LE CRIBLAGE A HAUT-DEBIT DE MOLECULES D'INTERET. 有权对于功能CASCADE MODULATE CAN并在选择性配目标暗示的检测方法及其使用的利益分子的高通量筛选
公开(公告)号：EP1743178A2
公开(公告)日：2007-01-17
申请号：EP05762419.9
申请日：2005-04-25
申请人： Centre National de la Recherche Scientifique , Université de Montpellier I , Universite de Montpellier II
IPC分类号： G01N33/68
CPC分类号： G01N33/6854 , C07K2317/622 , C12Q1/025 , G01N33/5041 , G01N33/686 , G01N33/6872 , G01N2500/00
摘要： The invention concerns a method for identifying a ligand capable of selectively modulating a functional cascade involving a target, and uses thereof for high-throughput screening of molecules of interest, in particular therapeutic (medicine). Said method comprises at least the following steps: a) identifying an antibody or an antibody fragment comprising at least one of the variable domains of an immunoglobulin chain, capable of binding to said target and modulating said functional cascade involving said target; b) screening from a bank of molecules, ligands modulating the bond between said target and the antibody or antibody fragment identified in a); and c) identifying among said modulating ligands obtained in b), those capable of modulating said functional cascade.
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公开(公告)号：EP4025604A1
公开(公告)日：2022-07-13
申请号：EP20771782.8
申请日：2020-09-03
申请人： Institut National de la Santé et de la Recherche Médicale (INSERM) , Université de Montpellier , Institut Regional du Cancer de Montpellier , CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS) , Institut Pasteur de Lille , Université de Lille
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公开(公告)号：EP3245229B1
公开(公告)日：2019-07-24
申请号：EP16700495.1
申请日：2016-01-14
申请人： INSERM (Institut National de la Santé et de la Recherche Médicale) , Université Paris Diderot - Paris 7 , Institut Regional du Cancer de Montpellier , Université de Montpellier
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