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1.发明公开DERIVES D'ACIDE HYDROXY-BISPHOSPHONIQUE COMME VECTEUR CIBLANT LE TISSU OSSEUX 有权羟基二膦酸衍生物比骨组织LOOKING VECTORS
公开(公告)号：EP2240501A1
公开(公告)日：2010-10-20
申请号：EP09700113.5
申请日：2009-01-05
申请人： Université de Nantes , Chu Nantes , INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM) , Centre National de la Recherche Scientifique (CNRS)
发明人： EGOROV, Maxim , FORTUN, Yannick , HEYMANN, Dominique , LEBRETON, Jacques , MATHE, Monique , PADRINES, Marc , REDINI, Françoise
IPC分类号： C07F9/38 , A61K31/663 , A61P35/00 , A61P19/10 , A61P3/14
CPC分类号： C07F9/3873 , C07F9/5728
摘要： The present invention relates to hydroxy-bisphosphonic acid derivatives corresponding to general formula (I): in which: - n and m denote, independently of one another, an integer ranging from 1 to 4, - X denotes an oxygen atom or an N-R3 group, - R1 and R3 denote, independently of one another, a linear or branched C1 to C6 alkyl group, and - R2 denotes a residue of a molecule of therapeutic or diagnostic interest, or pharmaceutically acceptable salts of said derivatives, and also the method for the preparation thereof and the therapeutic or diagnostic use thereof.
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2.发明授权DERIVES D'ACIDE HYDROXY-BISPHOSPHONIQUE COMME VECTEUR CIBLANT LE TISSU OSSEUX 有权羟基二膦酸衍生物比骨组织LOOKING VECTORS
公开(公告)号：EP2240501B1
公开(公告)日：2015-10-14
申请号：EP09700113.5
申请日：2009-01-05
申请人： Université de Nantes , CHU Nantes , INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM) , Centre National de la Recherche Scientifique (CNRS)
发明人： EGOROV, Maxim , FORTUN, Yannick , HEYMANN, Dominique , LEBRETON, Jacques , MATHE, Monique , PADRINES, Marc , REDINI, Françoise
IPC分类号： C07F9/38 , A61K31/663 , A61P35/00 , A61P19/10 , A61P3/14
CPC分类号： C07F9/3873 , C07F9/5728
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公开(公告)号：EP2240500B1
公开(公告)日：2014-10-01
申请号：EP09700083.0
申请日：2009-01-05
申请人： Université de Nantes , CHU Nantes , INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM) , Centre National de la Recherche Scientifique (CNRS)
发明人： EGOROV, Maxim , FORTUN, Yannick , HEYMANN, Dominique , LEBRETON, Jacques , MATHE, Monique , PADRINES, Marc , REDINI, Françoise
IPC分类号： C07F9/38
CPC分类号： C07F9/386 , C07F9/3873 , C07F9/5728
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公开(公告)号：EP2240500A1
公开(公告)日：2010-10-20
申请号：EP09700083.0
申请日：2009-01-05
申请人： Université de Nantes , Chu Nantes , INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM) , Centre National de la Recherche Scientifique (CNRS)
发明人： EGOROV, Maxim , FORTUN, Yannick , HEYMANN, Dominique , LEBRETON, Jacques , MATHE, Monique , PADRINES, Marc , REDINI, Françoise
IPC分类号： C07F9/38
CPC分类号： C07F9/386 , C07F9/3873 , C07F9/5728
摘要： The present invention relates to a method for preparing a hydroxy-bisphosphonic acid derivative or a salt thereof, from the corresponding carboxylic acid, comprising the following steps: - activation of the carboxylic acid function in the form of the boronate derivative thereof through the action of a borane, then - reaction with tris(trimethylsilyl)phosphite, under Arbuzov conditions - treatment with an alcohol, chosen in particular from an aliphatic alcohol or trifluoromethanol, and - separation of the hydroxy-bisphosphonic acid derivative formed, from the reaction medium.
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公开(公告)号：EP3412652A1
公开(公告)日：2018-12-12
申请号：EP17305664.9
申请日：2017-06-06
申请人： INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM) , CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE , Universite de Nantes , Chu Nantes
IPC分类号： C07C311/21 , C07C311/44 , A61P35/04 , A61K31/63
CPC分类号： C07C311/21 , C07C311/44
摘要： The present invention concerns a compound having the following formula (I):
wherein:
- A is in particular -N(R' a )-C(=O)-R, R' a being H or a (C 1 -C 6 )alkyl group, and R being preferably a group having the following formula (II):
- X is in particular chosen from the group consisting of: -SO 2 -N(R' b )-, R' b being H or a (C 1 -C 6 )alkyl group, -N(R" b )-SO 2 -, R" b being H or a (C 1 -C 6 )alkyl group, -CO-NH-, and -NH-CO-,
for use for the treatment of cancers, such as metastatic cancers.-
公开(公告)号：EP4087853A1
公开(公告)日：2022-11-16
申请号：EP21700012.4
申请日：2021-01-08
申请人： NANTES UNIVERSITÉ , Centre national de la recherche scientifique , INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE - INSERM
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公开(公告)号：EP3883922A1
公开(公告)日：2021-09-29
申请号：EP19816213.3
申请日：2019-11-22
发明人： FLEURY, Fabrice , DEMEYER, Alexandre , WEIGEL, Pierre , CHENAIS, Benoit , MATHÉ, Monique , LEBRETON, Jacques
IPC分类号： C07C309/51 , C07C309/46 , C07C309/45 , C07C309/41 , C07C311/14 , C07C311/08 , A61K31/145 , C07C311/21
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公开(公告)号：EP3634948A1
公开(公告)日：2020-04-15
申请号：EP18728642.2
申请日：2018-06-06
申请人： Institut National de la Santé et de la Recherche Médicale (INSERM) , Centre National de la Recherche Scientifique , Universite de Nantes , Chu, Nantes
IPC分类号： C07C311/21 , C07C311/44 , A61K31/63 , A61P11/06
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公开(公告)号：EP3634949A1
公开(公告)日：2020-04-15
申请号：EP18728643.0
申请日：2018-06-06
申请人： Institut National de la Santé et de la Recherche Médicale (INSERM) , Centre National de la Recherche Scientifique , Universite de Nantes , Chu, Nantes
IPC分类号： C07C311/21 , C07C311/44 , A61P35/04 , A61K31/63
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