公开(公告)号：EP2758369B1

公开(公告)日：2016-03-23

申请号：EP12781454.9

申请日：2012-09-21

申请人： Centre National de la Recherche Scientifique ,  Université de Strasbourg

发明人： RUAT, Martial ,  FAURE, Hélène ,  ROUDAUT, Hermine ,  HOCH, Lucile ,  SCHOENFELDER, Angèle ,  TADDEI, Maurizio ,  MANN, André

IPC分类号： C07C279/22 ,  A61K31/155

CPC分类号： C07C279/24 ,  C07C279/22 ,  G01N33/5011 ,  G01N33/5041 ,  G01N33/57492

公开(公告)号：EP2758369A1

公开(公告)日：2014-07-30

申请号：EP12781454.9

申请日：2012-09-21

申请人： Centre National de la Recherche Scientifique ,  Université de Strasbourg

发明人： RUAT, Martial ,  FAURE, Hélène ,  ROUDAUT, Hermine ,  HOCH, Lucile ,  SCHOENFELDER, Angèle ,  TADDEI, Maurizio ,  MANN, André

IPC分类号： C07C279/22 ,  A61K31/155

CPC分类号： C07C279/24 ,  C07C279/22 ,  G01N33/5011 ,  G01N33/5041 ,  G01N33/57492

摘要： The present invention relates to novel compounds having the following formula (I), and the use thereof as a drug, particularly for the treatment of tumors associated with hyperactivation of the hedgehog protein signaling pathway, for the treatment of neurodegenerative diseases, for the treatment of diseases related to cerebral development (holoprosencephaly), for stem cell monitoring, for the treatment of cerebrovascular accidents and cardiovascular accidents, for the treatment of diseases involving oligodendrocytes and diseases involving neurolemmocytes, for application thereof
in vitro for modulating human or animal stem cell renewal, and for the treatment of diabetes. The present invention also relates to pharmaceutical compositions comprising at least one compound having formula (I). The invention also relates to a method for radio-marking compounds having formula (I), the marked compounds, and the use of said compounds as research tools. Finally, the present invention also relates to a method for screening and/or identifying ligands in the Smoothened receptor (Smo) binding sites, methods for identifying agonists and antagonists of the Smoothened receptor, and a method for identifying cells.

公开(公告)号：EP2456754B1

公开(公告)日：2014-02-26

申请号：EP10747908.1

申请日：2010-07-19

申请人： Université de Strasbourg ,  Centre National de la Recherche Scientifique

发明人： RUAT, Martial ,  FAURE, Hélène ,  TRAIFFORT, Elisabeth ,  ROUDAUT, Hermine ,  MANN, André ,  SCHOENFELDER, Angèle ,  TADDEI, Maurizio ,  MANETTI, Fabrizio ,  SOLINAS, Antonio

IPC分类号： C07C279/22 ,  A61K31/155 ,  A61P3/10 ,  A61P25/00 ,  C07D209/08 ,  C07D209/14 ,  C07D213/56 ,  C07D213/81 ,  C07D307/68 ,  C07D513/04 ,  C07D295/155

CPC分类号： C07C279/22 ,  A61K31/155 ,  C07C2601/14 ,  C07D209/08 ,  C07D209/14 ,  C07D213/56 ,  C07D213/81 ,  C07D295/155 ,  C07D307/68 ,  C07D317/68 ,  C07D513/04

公开(公告)号：EP2456754A1

公开(公告)日：2012-05-30

申请号：EP10747908.1

申请日：2010-07-19

申请人： Université de Strasbourg ,  Centre National De La Recherche Scientifique

发明人： RUAT, Martial ,  FAURE, Hélène ,  TRAIFFORT, Elisabeth ,  ROUDAUT, Hermine ,  MANN, André ,  SCHOENFELDER, Angèle ,  TADDEI, Maurizio ,  MANETTI, Fabrizio ,  SOLINAS, Antonio

IPC分类号： C07C279/22 ,  A61K31/155 ,  A61P3/10 ,  A61P25/00 ,  C07D209/08 ,  C07D209/14 ,  C07D213/56 ,  C07D213/81 ,  C07D307/68 ,  C07D513/04 ,  C07D295/155

CPC分类号： C07C279/22 ,  A61K31/155 ,  C07C2601/14 ,  C07D209/08 ,  C07D209/14 ,  C07D213/56 ,  C07D213/81 ,  C07D295/155 ,  C07D307/68 ,  C07D317/68 ,  C07D513/04

摘要： The present invention relates to acyl guanidine derivatives modulating the hedgehog protein signaling pathway to be used as drugs, in particular for treating diseases involving a tissue dysfunction associated with a deregulation of the hedgehog protein signaling pathway, as well as to pharmaceutical compositions containing same. The present invention also relates to novel acyl guanidine derivatives as such.

摘要翻译： 本发明涉及调节用作药物的刺猬蛋白信号传导途径的酰基胍衍生物，特别是涉及治疗涉及与刺猬蛋白信号传导途径失调相关的组织功能障碍的疾病以及含有该刺激因子的药物组合物。 本发明还涉及本发明的酰基胍衍生物。