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1.发明授权NOUVEAUX COMPOSÉS MODULATEURS DE LA VOIE DE SIGNALISATION DES PROTÉINES HEDGEHOG, LEURS FORMES MARQUÉES, ET APPLICATIONS 有权用于调制的刺猬蛋白信号通路的新化合物，它们标明形态及其用途
公开(公告)号：EP2758369B1
公开(公告)日：2016-03-23
申请号：EP12781454.9
申请日：2012-09-21
发明人： RUAT, Martial , FAURE, Hélène , ROUDAUT, Hermine , HOCH, Lucile , SCHOENFELDER, Angèle , TADDEI, Maurizio , MANN, André
IPC分类号： C07C279/22 , A61K31/155
CPC分类号： C07C279/24 , C07C279/22 , G01N33/5011 , G01N33/5041 , G01N33/57492
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2.发明授权
公开(公告)号：EP2291352B1
公开(公告)日：2017-09-13
申请号：EP09733789.3
申请日：2009-04-16
发明人： RUAT, Martial , FAURE, Hélène , TRAIFFORT, Elisabeth , SCHOENFELDER, Angèle , MANN, André , TADDEI, Maurizio , SOLINAS, Antonio , MANETTI, Fabrizio
IPC分类号： C07C335/26 , C07C275/54 , C07D209/08 , C07D209/14 , C07D213/81 , C07D235/14 , C07D307/68 , C07D317/68 , C07D319/18 , C07D333/38 , C07D471/04 , C07D513/04 , A61K31/17 , A61P3/10 , A61P25/00
CPC分类号： C07C335/26 , C07C275/54 , C07C335/08 , C07C2601/14 , C07D209/08 , C07D209/14 , C07D213/81 , C07D235/14 , C07D235/18 , C07D307/68 , C07D317/68 , C07D319/18 , C07D333/38 , C07D471/04 , C07D513/04
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3.发明公开NOUVEAUX COMPOSÉS MODULATEURS DE LA VOIE DE SIGNALISATION DES PROTÉINES HEDGEHOG, LEURS FORMES MARQUÉES, ET APPLICATIONS 有权用于调制的刺猬蛋白信号通路的新化合物，它们标明形态及其用途
公开(公告)号：EP2758369A1
公开(公告)日：2014-07-30
申请号：EP12781454.9
申请日：2012-09-21
发明人： RUAT, Martial , FAURE, Hélène , ROUDAUT, Hermine , HOCH, Lucile , SCHOENFELDER, Angèle , TADDEI, Maurizio , MANN, André
IPC分类号： C07C279/22 , A61K31/155
CPC分类号： C07C279/24 , C07C279/22 , G01N33/5011 , G01N33/5041 , G01N33/57492
摘要： The present invention relates to novel compounds having the following formula (I), and the use thereof as a drug, particularly for the treatment of tumors associated with hyperactivation of the hedgehog protein signaling pathway, for the treatment of neurodegenerative diseases, for the treatment of diseases related to cerebral development (holoprosencephaly), for stem cell monitoring, for the treatment of cerebrovascular accidents and cardiovascular accidents, for the treatment of diseases involving oligodendrocytes and diseases involving neurolemmocytes, for application thereof
in vitro for modulating human or animal stem cell renewal, and for the treatment of diabetes. The present invention also relates to pharmaceutical compositions comprising at least one compound having formula (I). The invention also relates to a method for radio-marking compounds having formula (I), the marked compounds, and the use of said compounds as research tools. Finally, the present invention also relates to a method for screening and/or identifying ligands in the Smoothened receptor (Smo) binding sites, methods for identifying agonists and antagonists of the Smoothened receptor, and a method for identifying cells.-
4.发明授权
公开(公告)号：EP2456754B1
公开(公告)日：2014-02-26
申请号：EP10747908.1
申请日：2010-07-19
发明人： RUAT, Martial , FAURE, Hélène , TRAIFFORT, Elisabeth , ROUDAUT, Hermine , MANN, André , SCHOENFELDER, Angèle , TADDEI, Maurizio , MANETTI, Fabrizio , SOLINAS, Antonio
IPC分类号： C07C279/22 , A61K31/155 , A61P3/10 , A61P25/00 , C07D209/08 , C07D209/14 , C07D213/56 , C07D213/81 , C07D307/68 , C07D513/04 , C07D295/155
CPC分类号： C07C279/22 , A61K31/155 , C07C2601/14 , C07D209/08 , C07D209/14 , C07D213/56 , C07D213/81 , C07D295/155 , C07D307/68 , C07D317/68 , C07D513/04
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5.发明公开DERIVES D'ACYL-GUANIDINES MODULATEURS DE LA VOIE DE SIGNALISATION DES PROTEINES HEDGEHOG 有权ACYL-GUANIDIN-DERIVATE ALS MODULATOREN DES HEDGEHOG-PROTEINSIGNALWEGES
公开(公告)号：EP2456754A1
公开(公告)日：2012-05-30
申请号：EP10747908.1
申请日：2010-07-19
发明人： RUAT, Martial , FAURE, Hélène , TRAIFFORT, Elisabeth , ROUDAUT, Hermine , MANN, André , SCHOENFELDER, Angèle , TADDEI, Maurizio , MANETTI, Fabrizio , SOLINAS, Antonio
IPC分类号： C07C279/22 , A61K31/155 , A61P3/10 , A61P25/00 , C07D209/08 , C07D209/14 , C07D213/56 , C07D213/81 , C07D307/68 , C07D513/04 , C07D295/155
CPC分类号： C07C279/22 , A61K31/155 , C07C2601/14 , C07D209/08 , C07D209/14 , C07D213/56 , C07D213/81 , C07D295/155 , C07D307/68 , C07D317/68 , C07D513/04
摘要： The present invention relates to acyl guanidine derivatives modulating the hedgehog protein signaling pathway to be used as drugs, in particular for treating diseases involving a tissue dysfunction associated with a deregulation of the hedgehog protein signaling pathway, as well as to pharmaceutical compositions containing same. The present invention also relates to novel acyl guanidine derivatives as such.
摘要翻译： 本发明涉及调节用作药物的刺猬蛋白信号传导途径的酰基胍衍生物，特别是涉及治疗涉及与刺猬蛋白信号传导途径失调相关的组织功能障碍的疾病以及含有该刺激因子的药物组合物。 本发明还涉及本发明的酰基胍衍生物。
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6.发明授权PROTEINES MEMBRANAIRES CTL (CHOLINE TRANSPORTER LIKE) IMPLIQUEES DANS LE TRANSPORT DE LA CHOLINE 有权膜蛋白的CTL（胆碱转运等）的胆碱的运输卷入时
公开(公告)号：EP1228091B1
公开(公告)日：2010-04-28
申请号：EP00974648.8
申请日：2000-11-03
CPC分类号： C07K14/47 , A61K38/00 , C12N2799/021
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7.发明授权DÉRIVÉS DE QUINOLINONE ET UTILISATION POUR TRAITER LES MALADIES CAUSÉES PAR LE DÉRÈGLEMENT DE LA FONCTION DES OSTÉOBLASTES 有权喹诺酮衍生物及其在治疗确定成骨细胞功能所致疾病中的应用
公开(公告)号：EP2640388B1
公开(公告)日：2017-10-11
申请号：EP11794858.8
申请日：2011-11-15
发明人： RUAT, Martial , FAURE, Hélène , GOROJANKINA, Tatiana , MANN, André , TADDEI, Maurizio , MANETTI, Fabrizio , SOLINAS, Antonio
IPC分类号： A61K31/4704 , A61P19/00 , C07D215/22 , C07D215/56
CPC分类号： C07D215/22 , A61K31/4704 , C07D215/56
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公开(公告)号：EP2640388A1
公开(公告)日：2013-09-25
申请号：EP11794858.8
申请日：2011-11-15
发明人： RUAT, Martial , FAURE, Hélène , GOROJANKINA, Tatiana , MANN, André , TADDEI, Maurizio , MANETTI, Fabrizio , SOLINAS, Antonio
IPC分类号： A61K31/4704 , A61P19/00
CPC分类号： C07D215/22 , A61K31/4704 , C07D215/56
摘要： The present invention relates to compounds which are quinolinone derivatives of general formula (I) capable of modulating the activity, in particular of inducing the differentiation, of stem and progenitor cells; these compounds are of use in the treatment of disorders related to a stem differentiation defect; the invention also relates to novel compounds among these quinolinone derivatives and to pharmaceutical compositions containing the same.
摘要翻译： 本发明涉及一种有通式（I）能够调节活性，特别是诱导分化干细胞和祖细胞的，中的喹啉酮的衍生物的化合物; 合成化合物在相关的肝细胞分化缺陷病症的治疗中的使用; 因此，本发明涉及本文中喹啉酮衍生物以及含有它们的药物组合物的新化合物。
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9.发明授权NOUVELLE UTILISATION DE LA MIFEPRISTONE ET DE SES DERIVES COMME MODULATEURS DE LA VOIE DE SIGNALISATION DES PROTEINES HEDGEHOG ET SES APPLICATIONS 有权用于调制的“刺猬” -PROTEINSIGNALWEGES及其应用米非司酮及其衍生物的新用途
公开(公告)号：EP1585526B1
公开(公告)日：2010-07-14
申请号：EP04704259.3
申请日：2004-01-22
IPC分类号： A61K31/575 , A61P31/10 , A61P25/28 , A61P35/00
CPC分类号： A61K31/56
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10.发明公开NOUVELLE UTILISATION DE LA MIFEPRISTONE ET DE SES DERIVES COMME MODULATEURS DE LA VOIE DE SIGNALISATION DES PROTEINES HEDGEHOG ET SES APPLICATIONS 有权用于调制的“刺猬” -PROTEINSIGNALWEGES及其应用米非司酮及其衍生物的新用途
公开(公告)号：EP1585526A2
公开(公告)日：2005-10-19
申请号：EP04704259.3
申请日：2004-01-22
IPC分类号： A61K31/575 , A61P31/10 , A61P25/28 , A61P35/00
CPC分类号： A61K31/56
摘要： The invention relates to a novel use of compounds having formula (I), including mifepristone (RU 486 or RU 38 486) and the derivative salts thereof, for the preparation of a medicament that can modulate (activate or inhibit) the Hedgehog protein signalling pathway, which is intended for the treatment of pathologies involving a tissue dysfunction linked to deregulation of said pathway.
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