专利检索 ap:("Universita' Degli Studi Di Padova") AND inv:"BICCIATO, Silvio" 第 1 页

1.

发明公开
PROGNOSIS OF BREAST CANCER PATIENTS BY MONITORING THE EXPRESSION OF TWO GENES 审中-公开
标题翻译：预测基于表达式两个基因的监测乳腺癌患者

公开(公告)号：EP2389448A1

公开(公告)日：2011-11-30

申请号：EP09778968.9

申请日：2009-01-21

申请人： Universita' Degli Studi Di Padova

发明人： PICCOLO, Stefano , CORDENONSI, Michelangelo , ADORNO, Maddalena , BICCIATO, Silvio

IPC分类号： C12Q1/68

CPC分类号： C12Q1/6886 , C12Q2600/112 , C12Q2600/118 , C12Q2600/136 , C12Q2600/158 , G16H50/30

摘要： The present invention relates to the expression of two genes, CyclinG2 and Sharp1, which correlates with prognosis in individuals having breast cancer. Specifically, this invention provides a method to stratify samples from breast cancer patients in a high or low recurrence risk in the years following primary tumor removal. This classification can be achieved through the analysis of protein or mRNA expression levels for the two identified genes. The invention also illustrates how CyclinG2 and Sharp1 have been identified in mammary cancer cell lines and validated in a large cohort of human patients as powerful metastasis predictors.