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公开(公告)号：EP3344757A1
公开(公告)日：2018-07-11
申请号：EP15774515.9
申请日：2015-09-04
发明人： PICCOLO, Stefano , AZZOLIN, Luca , PANCIERA, Tito , CORDENONSI, Michelangelo , ZANCONATO, Francesca , FUJIMURA, Atsushi
IPC分类号： C12N5/074 , C12N5/0797 , C12N5/071
CPC分类号： C12N5/0607 , A61K35/28 , A61K38/00 , C07K14/4705 , C12N5/0623 , C12N5/0631 , C12N5/0678 , C12N9/1025 , C12N2501/60 , C12N2506/08 , C12N2506/095 , C12N2506/22 , C12N2510/00
摘要： The present invention provides a method for generating somatic stem cells out of differentiated cells, somatic stem cells obtained by this method and a vector or composition for use in this method.
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2.发明公开PROGNOSIS OF BREAST CANCER PATIENTS BY MONITORING THE EXPRESSION OF TWO GENES 审中-公开预测基于表达式两个基因的监测乳腺癌患者
公开(公告)号：EP2389448A1
公开(公告)日：2011-11-30
申请号：EP09778968.9
申请日：2009-01-21
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6886 , C12Q2600/112 , C12Q2600/118 , C12Q2600/136 , C12Q2600/158 , G16H50/30
摘要： The present invention relates to the expression of two genes, CyclinG2 and Sharp1, which correlates with prognosis in individuals having breast cancer. Specifically, this invention provides a method to stratify samples from breast cancer patients in a high or low recurrence risk in the years following primary tumor removal. This classification can be achieved through the analysis of protein or mRNA expression levels for the two identified genes. The invention also illustrates how CyclinG2 and Sharp1 have been identified in mammary cancer cell lines and validated in a large cohort of human patients as powerful metastasis predictors.
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