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    Lentiviral vectors comprising endothelial cell specific promoters
    2.
    发明公开
    Lentiviral vectors comprising endothelial cell specific promoters 审中-公开
    Lentivirale Vektoren mit Endothelzellen spezifischen Promotoren

    公开(公告)号：EP1264892A2

    公开(公告)日：2002-12-11

    申请号：EP02011588.7

    申请日：2002-05-27

    申请人： Universita' Di Torino

    发明人： Naldini, Luigi ,  De Palma, Michele

    IPC分类号： C12N15/867 ,  C12N15/63 ,  C12N15/90 ,  A61K48/00

    CPC分类号： C12N15/86 ,  A61K48/00 ,  C12N2740/16043 ,  C12N2830/008 ,  C12N2830/48 ,  C12N2830/50 ,  C12N2830/85 ,  C12N2840/203 ,  C12N2840/44

    摘要： A lentiviral vector construct for transferring nucleotide sequences in vivo and ex vivo , which comprises transcription regulatory sequences of one or more genes preferentially expressed in endothelial cells of mammals, particularly sequences of the intronic and promoter regions of one or more human and murine genes preferentially expressed in endothelial cells. The invention also relates to the use of a lentiviral vector construct according to the invention for manufacturing a preparation for treating an angiogenesis-related pathology by gene delivery and selective expression in cells engaged in angiogenesis.

    摘要翻译： 一种用于在体内和体外转移核苷酸序列的慢病毒载体构建体，其包含优先在哺乳动物的内皮细胞中表达的一个或多个基因的转录调节序列，特别是优先表达的一个或多个人和鼠基因的内含子和启动子区的序列 在内皮细胞中。 本发明还涉及根据本发明的慢病毒载体构建体在制备用于通过基因递送和在从事血管发生的细胞中的选择性表达来治疗血管生成相关病理学的制剂的用途。