公开(公告)号：EP2317988A1

公开(公告)日：2011-05-11

申请号：EP09800015.1

申请日：2009-07-23

申请人： Universita' degli Studi di Milano

发明人： GAZZANIGA, Andrea ,  CEREA, Matteo ,  COZZI, Alberto ,  FOPPOLI, Anastasia Anna ,  TAVELLA, Gianaldo ,  ZEMA, Lucia

IPC分类号： A61K9/48 ,  A61K31/167

CPC分类号： A61K9/4816 ,  A61K31/167 ,  A61K47/38

摘要： The present invention refers to an oral dosage form intended for the time-controlled release of drugs comprising a container for one or more active ingredients optionally in admixture with pharmaceutically acceptable excipients, said container consisting of at least two parts or elements that can be joined together so as to seal the contents, at least one of said elements being composed of one or more hydrophilic polymers that undergo a decrease in the glassy-rubbery transition temperature when in contact with aqueous fluids, except for polymers with pH dependent solubility soluble only at pH values above 5, optionally in admixture with pharmaceutically acceptable excipients, the wall of the elements of the container being of such thickness as to delay the release of the contained drug with respect to the time of administration.